1. Analysis of the effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in patients with acute myocardial infarction
- Author
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Bosong Wang, Weidong Sun, Xiaoding Wang, Hong Xu, Jinlong Li, and Chengqin Li
- Subjects
medicine.medical_specialty ,medicine.drug_class ,030209 endocrinology & metabolism ,Acute myocardial infarction ,030204 cardiovascular system & hematology ,Gastroenterology ,Nitric oxide ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,law ,Internal medicine ,Lyophilized recombinant human brain natriuretic peptide ,medicine ,Natriuretic peptide ,Distribution (pharmacology) ,In patient ,Myocardial infarction ,business.industry ,Endothelial function ,General Medicine ,Human brain ,Creative commons ,medicine.disease ,medicine.anatomical_structure ,chemistry ,cardiovascular system ,Recombinant DNA ,Original Article ,business - Abstract
Objective: This study aims to analyze the effect of lyophilized recombinant human brain natriuretic peptide on the endothelial function of patients with acute myocardial infarction. Methods: One hundred and thirty-six patients with acute myocardial infarction in our hospital were randomly divided into a control group and an experimental group (68 cases each). The patients in the control group were treated by conventional treatment. The patients in the experimental group were treated with lyophilized recombinant human brain natriuretic peptide besides the conventional treatment. The levels of flow-mediated dilatation (FMD), serum nitric oxide (NO), and endothelin-1 were compared between the two groups before and after treatment. Results: Before treatment, there was no significant difference between the two groups in the level of FMD (P>0.05); after treatment, the level of FMD in the experimental group was higher than that in the control group, and the difference was statistically significant (P0.05); after treatment, the levels of serum NO and endothelin-1 in the experimental group significantly improved, which were better than those in the control group (P
- Published
- 2020