1. Correlation between the Expression of Topo IIα and Ki67 in Breast Cancer and its clinical Pathological characteristics
- Author
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Yu-Juan Liu, Ji-Hai Jin, and Dong-Xing Zheng
- Subjects
business.industry ,medicine.medical_treatment ,Topo IIα ,Estrogen receptor ,General Medicine ,medicine.disease ,03 medical and health sciences ,Breast cancer ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Progesterone receptor ,Cancer research ,Medicine ,Immunohistochemistry ,Original Article ,Clinical significance ,030212 general & internal medicine ,Lymph ,Pathological characteristics ,business ,Pathological ,Radical mastectomy - Abstract
Objective: To investigate the expression of Topo IIα and Ki67 and its clinical significance. Methods: The clinical pathological data of one hundred and sixteen invasive breast cancer patients who were admitted into our hospital from July 2013 to December 2015 and underwent radical mastectomy were retrospectively analyzed. The expression of topoisomerase (Topo) IIα and Ki67 was detected using immunohistochemical method, and the correlation between the two kinds of proteins and the general clinical pathological characteristics of the patients was analyzed. Results: The positive expression rates of Topo IIα and Ki67 in breast cancer were 58.6% and 75% respectively. The expression of Topo IIα was in no apparent correlation with the age, tumor size, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) (P>0.05), but in a correlation with the number of metastatic lymph glands (P
- Published
- 2017