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This study aimed to evaluate the effect of mineral supplementation, vitamin supplementation and deworming on humoral response against PPR vaccine in local goats. Group 1 and group 2 goats were given mineral supplementation and fat-soluble vitamin supplementation for 21 days. Group 3 goats were twice dewormed with Fenbendazole. Group 4 bucks were kept as controls. All bucks were vaccinated with the Pestivac vaccine. Antibodies detection was done using competitive ELISA from serum samples. Antigen shedding by vaccinated animals via nasal and fecal route was checked by the haemagglutination test and RT-PCR. All group 2 bucks, developed humoral protection against PPR within the 1st week. Only, 50 percent bucks of group 1 developed humoral protection against PPR after one week of vaccination. The mean percent inhibition value of competition-ELISA of group 2 was half the mean percent inhibition values of group 3 and group 4 after one week of vaccination. There was no antigen shedding through nasal or fecal route after vaccination in any animal included in the study. [ABSTRACT FROM AUTHOR]