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A transition from cereal-based agriculture to pastoralism in North China occurred around 3600 cal yr B.P., and corresponded to Northern Hemisphere cooling and the onset of an arid climate over North China. In this paper, we investigate the mechanisms for the ~3600 cal yr B.P. climate transition that may have triggered this change in Chinese civilization based on a compilation of 33 high-resolution paleoclimate records spanning the 4000–3000 cal yr B.P. interval. Results show that North and South China experienced a meridional dipole pattern of the climate change. From 4000 to 3600 cal yr B.P., the region north of 30°N was wet and the region south of 30°N was dry, then from 3600 to 3000 cal yr B.P., the pattern reversed with a drier north and a wetter south. We found that this climate transition was related to the onset of a more El Niño-like state in the tropical Pacific Ocean after ~3600 cal yr B.P., which resulted in more precipitation in South China but less precipitation in North China. Climate in the marginal monsoon areas of North China deteriorated, becoming more cold and arid, and pastoralism replaced cereal agriculture as the dominant mode of subsistence. Our study highlights the important role of the paleo-El Niño-Southern Oscillation (paleo-ENSO) for the evolution of civilization in China. • North China transitioned to pastoralism around 3600 cal yr B.P. • A shift in East Asia's dipole climate pattern was observed at the same period. • This climate change was influenced by the paleo-ENSO. • The paleo-ENSO significantly impacted the progression of Chinese civilization. [ABSTRACT FROM AUTHOR]