1. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases
- Author
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Mastracci, Teresa L, Apte, Minoti, Amundadottir, Laufey T, Alvarsson, Alexandra, Artandi, Steven, Bellin, Melena D, Bernal-Mizrachi, Ernesto, Caicedo, Alejandro, Campbell-Thompson, Martha, Cruz-Monserrate, Zobeida, Ouaamari, Abdelfattah El, Gaulton, Kyle J, Geisz, Andrea, Goodarzi, Mark O, Hara, Manami, Hull-Meichle, Rebecca L, Kleger, Alexander, Klein, Alison P, Kopp, Janel L, Kulkarni, Rohit N, Muzumdar, Mandar D, Naren, Anjaparavanda P, Oakes, Scott A, Olesen, Søren S, Phelps, Edward A, Powers, Alvin C, Stabler, Cherie L, Tirkes, Temel, Whitcomb, David C, Yadav, Dhiraj, Yong, Jing, Zaghloul, Norann A, Sander, Maike, and Pandol, Stephen J
- Subjects
Diabetes ,Digestive Diseases ,Rare Diseases ,Cancer ,Pancreatic Cancer ,Metabolic and endocrine ,Good Health and Well Being ,Humans ,Diabetes Mellitus ,Islets of Langerhans ,Pancreas ,Pancreas ,Exocrine ,Pancreatic Diseases ,exocrine pancreas ,endocrine pancreas ,exocrine-endocrine crosstalk ,integrated physiology ,interpancreatic communication ,AP ,acute pancreatitis ,AP-D ,acute pancreatitis-related diabetes ,CCK ,cholecystokinin ,cCRE ,cis-regulatory element ,CF ,cystic fibrosis ,CFRD ,cystic fibrosis-related diabetes ,CFTR ,cystic fibrosis transmembrane conductance regulator ,CP ,chronic pancreatitis ,CP-D ,chronic pancreatitis-related diabetes ,ECM ,extracellular matrix ,eIF5A ,eukaryotic initiation factor 5A ,EPI ,exocrine pancreatic insufficiency ,GWAS ,genome-wide association study ,MRI ,magnetic resonance imaging ,MRCP ,magnetic resonance cholangiopancreatography ,NIDDK ,National Institute of Diabetes and Digestive and Kidney Diseases ,NIH ,National Institutes of Health ,PSC ,pancreatic stellate cells ,PDAC ,pancreatic ductal adenocarcinoma ,PDLO ,pancreatic-duct-like organoid ,PRSS1 ,trypsinogen ,T1D ,type 1 diabetes ,T2D ,type 2 diabetes ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
AbstractThe "Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases" Workshop was a 1.5-day scientific conference at the National Institutes of Health (Bethesda, MD) that engaged clinical and basic science investigators interested in diseases of the pancreas. This report summarizes the workshop proceedings. The goal of the workshop was to forge connections and identify gaps in knowledge that could guide future research directions. Presentations were segregated into 6 major themes, including (a) Pancreas Anatomy and Physiology; (b) Diabetes in the Setting of Exocrine Disease; (c) Metabolic Influences on the Exocrine Pancreas; (d) Genetic Drivers of Pancreatic Diseases; (e) Tools for Integrated Pancreatic Analysis; and (f) Implications of Exocrine-Endocrine Crosstalk. For each theme, there were multiple presentations followed by panel discussions on specific topics relevant to each area of research; these are summarized herein. Significantly, the discussions resulted in the identification of research gaps and opportunities for the field to address. In general, it was concluded that as a pancreas research community, we must more thoughtfully integrate our current knowledge of the normal physiology as well as the disease mechanisms that underlie endocrine and exocrine disorders so that there is a better understanding of the interplay between these compartments.
- Published
- 2022