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3 results on '"Quin, Y."'

1. INternational Study Group of Pediatric Pancreatitis

Author

Uc, Aliye, Perito, Emily R, Pohl, John F, Shah, Uzma, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D, Ellery, Kate M, Fishman, Douglas S, Gariepy, Cheryl E, Giefer, Matthew J, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan W, Husain, Sohail Z, Maqbool, Asim, Mascarenhas, Maria R, McFerron, Brian A, Morinville, Veronique D, Lin, Tom K, Liu, Quin Y, Nathan, Jaimie D, Rhee, Sue J, Ooi, Chee Y, Sellers, Zachary M, Schwarzenberg, Sarah Jane, Serrano, Jose, Troendle, David M, Werlin, Steven L, Wilschanski, Michael, Zheng, Yuhua, Yuan, Ying, and Lowe, Mark E

Subjects
Clinical Research, Burden of Illness, Mental Health, Digestive Diseases, Depression, Cancer, Pediatric Research Initiative, Pediatric, Oral and gastrointestinal, Good Health and Well Being, Acute Disease, Biomedical Research, Child, Child, Preschool, Cohort Studies, Diabetes Mellitus, Humans, International Agencies, Multicenter Studies as Topic, Observational Studies as Topic, Pancreatic Neoplasms, Pancreatitis, Pancreatitis, Chronic, Research Design, Surveys and Questionnaires, Children, registry, pancreatitis, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical Sciences, Gastroenterology & Hepatology
Abstract

We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.

Published
2018

2. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis

Author

Troendle, David M, Fishman, Douglas S, Barth, Bradley A, Giefer, Matthew J, Lin, Tom K, Liu, Quin Y, Abu-El-Haija, Maisam, Bellin, Melena D, Durie, Peter R, Freedman, Steven D, Gariepy, Cheryl, Gonska, Tanja, Heyman, Melvin B, Himes, Ryan, Husain, Sohail Z, Kumar, Soma, Lowe, Mark E, Morinville, Veronique D, Ooi, Chee Y, Palermo, Joseph, Pohl, John F, Schwarzenberg, Sarah Jane, Werlin, Steven, Wilschanski, Michael, Zimmerman, M Bridget, and Uc, Aliye

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Digestive Diseases, Clinical Research, Acute Disease, Adolescent, Age Factors, Child, Child, Preschool, Cholangiopancreatography, Endoscopic Retrograde, Databases, Factual, Female, Humans, Male, Pancreatitis, Pancreatitis, Chronic, Practice Patterns, Physicians', Recurrence, Stents, Time Factors, Treatment Outcome, bile ducts, bile stent, children, endotherapy, pancreatic ducts, pancreatic stent, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectiveThe aim of this study was to characterize utilization and benefit of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).MethodsFrom August 2012 to February 2015, 301 children with ARP or CP were enrolled in the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) study. Physicians reported utilization and benefit of therapeutic ERCP at enrollment. Differences were analyzed using appropriate statistical methods.ResultsOne hundred seventeen children (38.9%) underwent at least 1 therapeutic ERCP. The procedure was more commonly performed in children with CP compared with those with ARP (65.8% vs 13.5%, P < 0.0001). Utility of therapeutic ERCP was reported to be similar between ARP and CP (53% vs 56%, P = 0.81) and was found to be helpful for at least 1 indication in both groups (53/99 patients [53.5%]). Predictors for undergoing therapeutic ERCP were presence of obstructive factors in ARP and CP, Hispanic ethnicity, or white race in CP.ConclusionsTherapeutic ERCP is frequently utilized in children with ARP or CP and may offer benefit in selected cases, specifically if ductal obstruction is present. Longitudinal studies are needed to clarify the efficacy of therapeutic ERCP and to explore subgroups that might have increased benefit from such intervention.

Published
2017

3. INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study

Author

Kate Ellery, Sarah Jane Schwarzenberg, Douglas S. Fishman, Ying Yuan, David M. Troendle, Matthew J. Giefer, Bradley A. Barth, Quin Y. Liu, Jose Serrano, Melena D. Bellin, John F. Pohl, Asim Maqbool, Emily R. Perito, Mark E. Lowe, Brian A. McFerron, Maria R. Mascarenhas, Sohail Z. Husain, Ryan Himes, Maisam Abu-El-Haija, Steven L. Werlin, Aliye Uc, Melvin B. Heyman, Veronique D. Morinville, Jaimie D. Nathan, Cheryl E. Gariepy, Tom K. Lin, Uzma Shah, Sue Rhee, Michael Wilschanski, Chee Y. Ooi, Tanja Gonska, Yuhua Zheng, and Zachary M. Sellers

Subjects
Research design, medicine.medical_specialty, Biomedical Research, Endocrinology, Diabetes and Metabolism, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Quality of life, Pancreatitis, Chronic, Surveys and Questionnaires, 030225 pediatrics, Internal medicine, Diabetes Mellitus, Internal Medicine, medicine, Humans, Multicenter Studies as Topic, Child, Depression (differential diagnoses), Hepatology, business.industry, International Agencies, medicine.disease, Pancreatic Neoplasms, Observational Studies as Topic, Pancreatitis, Research Design, Social history (medicine), Child, Preschool, Acute Disease, Cohort, 030211 gastroenterology & hepatology, business, Psychosocial, Cohort study
Abstract

We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes.Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.

Published
2018
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