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Your search keyword '"Cosmeri Rizzato"' showing total 11 results
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11 results on '"Cosmeri Rizzato"'

1. A multifactorial score for pancreatic ductal adenocarcinoma risk prediction

Author

Manuel Gentiluomo, Alice Alessandra Galeotti, Cosmeri Rizzato, Ofure Obazee, John P. Neoptolemos, Claudio Pasquali, Michael Nentwich, Giulia Martina Cavestro, Raffaele Pezzilli, William Greenhalf, Bernd Holleczek, Cornelia Schroeder, Ben Schöttker, Audrius Ivanauskas, Laura Ginocchi, Timothy J. Key, Péter Hegyi, Livia Archibugi, Erika Darvasi, Daniela Basso, Cosimo Sperti, Maarten F. Bijlsma, Orazio Palmieri, Viktor Hlavac, Renata Talar-Wojnarowska, Beatrice Mohelnikova-Duchonova, Thilo Hackert, Yogesh Vashist, Ondrej Strouhal, Hanneke van Laarhoven, Francesca Tavano, Martin Lovecek, Christos Dervenis, Ferenc Izbéki, Andrea Padoan, Ewa Małecka-Panas, Evaristo Maiello, Giuseppe Vanella, Gabriele Capurso, Jakob R. Izbicki, George E. Theodoropoulos, Krzysztof Jamroziak, Verena Katzke, Rudolf Kaaks, Andrea Mambrini, Ioannis S. Papanikolaou, Richárd Szmola, Andrea Szentesi, Juozas Kupcinskas, Simona Bursi, Eithne Costello, Ugo Boggi, Anna Caterina Milanetto, Stefano Landi, Maria Gazouli, Ludmila Vodickova, Pavel Soucek, Domenica Gioffreda, Federica Gemignani, Hermann Brenner, Oliver Strobel, Markus W. Büchler, Pavel Vodicka, Salvatore Paiella, Federico Canzian, and Daniele Campa

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2019
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2. SLC22A3 polymorphisms may influence overall patient survival- PANDORA study

Author

Rita T. Lawlor, Ludmila Vodickova, Paola Fogar, Gianfranco Delle Fave, Oliver Strobel, Martin Lovecek, Zdenek Kala, Federico Canzian, Beatrice Mohelnikova-Duchonova, Ewa Małecka-Panas, Cosmeri Rizzato, Thilo Hackert, Cosimo Sperti, Franco Bambi, Sergio Pedrazzoli, Niccola Funel, Valerio Pazienza, Anna Caterina Milanetto, Paola Pacetti, Francesca Tavano, Roberto Valente, Andrea Mambrini, Gabriele Capurso, Renata Talar-Wojnarowska, Martin Oliverius, Nathalia A. Giese, Stefano Ermini, Stefano Landi, Daniele Campa, Pavel Soucek, Giuseppe Malleo, Raffaele Pezzilli, Pavel Vodicka, Carlo Federico Zambon, Ada Piepoli, Maria Gazouli, Domenica Gioffreda, Simona Bursi, David J. Hughes, Ivana Holcatova, and Ondrej Strouhal

Subjects
medicine.medical_specialty, Hepatology, biology, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Gastroenterology, biology.protein, Medicine, Patient survival, business, SLC22A3
Published
2018
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3. Novel pancreatic cancer susceptibility loci discovered through genome-wide association studies

Author

Federico Canzian, Daniele Campa, Ofure Obazee, Cosmeri Rizzato, Maria Gazouli, Giulia Martina Cavestro, Aldo Scarpa, Stefania Moz, Raffaele Pezzilli, Andrea Mambrini, Ugo Boggi, Gabriele Capurso, Livia Archibugi, Franco Bambi, Angelo Andriulli, Pavel Soucek, Pavel Vodicka, Beatrice Mohelnikova-Duchonova, Martin Lovecek, Thilo Hackert, John P. Neoptolemos, Oliver Strobel, Yogesh K. Vashist, Jakob R. Izbicki, Rudolf Kaaks, Hermann Brenner, Peter Hegyi, Olivier Busch, H. Bas Bueno-de-Mesquita, Petra H.M. Peeters, Ewa Malecka-Panas, Krzysztof Jamroziak, Juozas Kupcinskas, Eithne Costello, Kay-Tee Khaw, Timothy J. Key, Rachael Stolzenberg-Solomon, Brian Wolpin, Alison P. Klein, and Laufey T. Amundadottir

Subjects
Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology
Published
2018
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4. Functional polymorphisms in the CDKN2A generegion affect pancreatic cancer risk

Author

John P. Neoptolemos, Frederike Dijk, Stefano Landi, Raffaele Pezzilli, Kay-Tee Khaw, Yogesh K. Vashist, Aldo Scarpa, Pavel Vodicka, Hermann Brenner, Francesca Tavano, Manuela Pastore, Timothy J. Key, Ugo Boggi, Federico Canzian, Gianfranco Delle Fave, Renata Talar-Wojnarowska, Daniele Campa, Anna Caterina Milanetto, Pavel Soucek, Oliver Strobel, Manuel Gentiluomo, Cosmeri Rizzato, Andrea Mambrini, Maria Gazouli, and Juozas Kupcinskas

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, Apoptosis Regulatory Proteins, medicine.disease, Affect (psychology), CDKN2A, Pancreatic cancer, Internal medicine, medicine, business
Published
2016
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5. Functional polymorphisms in the CDKN2A- CDKN2B gene regions affect pancreatic cancer risk

Author

Juozas Kupcinskas, Kay-Tee Khaw, Manuela Pastore, Raffaele Pezzilli, Federico Canzian, Hermann Brenner, Thilo Hackert, Pavel Vodicka, Francesca Tavano, Manuel Gentiluomo, Renata Talar-Wojnarowska, Maria Gazouli, Frederike Dijk, Eithne Costello, Daniele Campa, Yogesh K. Vashist, Anna Caterina Milanetto, Pavel Soucek, Stefano Landi, Giulia Martina Cavestro, Gabriele Capurso, Cosmeri Rizzato, Andrea Mambrini, Ugo Boggi, and Aldo Scarpa

Subjects
Hepatology, CDKN2A, business.industry, Endocrinology, Diabetes and Metabolism, CDKN2B, Pancreatic cancer, Gastroenterology, Cancer research, Medicine, Affect (psychology), business, medicine.disease, Gene
Published
2016
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6. Novel pancreatic cancer susceptibility loci discovered through genome-wide association studies

Author

Giulia Martina Cavestro, H. Bas Bueno-de-Mesquita, Stefano Landi, Maria Gazouli, Yogesh K. Vashist, Daniele Campa, Beatrice Mohelnikova-Duchonova, Claudio Pasquali, Hermann Brenner, Oliver Strobel, Raffaele Pezzilli, Gabriele Capurso, Pavel Vodicka, Ewa Małecka-Panas, Maarten F. Bijlsma, Cosmeri Rizzato, Francesca Tavano, Andrea Mambrini, Brian M. Wolpin, John P. Neoptolemos, Aldo Scarpa, Alison P. Klein, Timothy J. Key, Juozas Kupcinskas, Federico Canzian, Rachael Z. Stolzenberg-Solomon, Niccola Funel, Laufey T. Amundadottir, and Thilo Hackert

Subjects
Hepatology, business.industry, ORAI1, Endocrinology, Diabetes and Metabolism, HEK 293 cells, Lipid microdomain, Gastroenterology, Regulator, STIM1, Transfection, Cell biology, Förster resonance energy transfer, Pi, Medicine, business
Abstract

s / Pancreatology 15 (2015) S1eS141 S49 sensor protein Stim1 in response to Ca2þ release from the ER. Orai1then undergoes slow Ca2þ -dependent inactivation (SCDI) that is mediated by binding of the regulator protein SARAF to Stim1. Aims: In this study our aimwas to characterize the regulation of Orai1. Materials & methods: Human embryonic kidney 293 cells were transfected with different plasmid constructs. We used SCDI by SARAF as a reporter of the conformation and microdomain localization of the Orai1Stim1 complex. FRET was used to follow interaction of Stim1-SARAF and Ca2þ current measurement to determine Orai1 activity. Results: Interaction of SARAF with Stim1 required the presence of Stim1-Orai1 in the ER/PMmicrodomain that is tethered by E-Syt1, stabilized by Septin4 and enriched in PI(4,5)P2. Notably, selective targeting of Stim1 to PI(4,5)P2-rich or to PI(4,5)P2-poor microdomains revealed that SCDI by SARAF is observed only when the Stim1-Orai1 complex is within the PI(4,5) P2-rich microdomain. Measuring the dynamics of Stim1-Orai1 localization using PI(4,5)P2-rich or PI(4,5)P2-poor microdomain probes revealed that store depletion is followed by transient Stim1-Orai1 formation in the PI(4,5) P2-poor microdomain where the channel is fully active, which then translocates to the PI(4,5)P2-rich domain to recruit SARAF and initiates SCDI. Conclusion: These findings reveal the role of the ER/PM tethers in the regulation of Orai1 function and Ca2þ influx and describe a new mode of regulation by PI(4,5)P2 involving translocation between PI(4,5)P2 microdomains.

Published
2015
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7. Genetic variants associated with PDAC also contribute to chronic pancreatitis susceptibility

Author

Heiko Witt, Debra T. Silverman, Marta Rava, Núria Malats, Nathalia A. Giese, Josefina Mora, Daniele Camp, Tomàs López, Cosmeri Rizzato, Mahmud M. Barmada, Frank Ulrich Weiss, Stephen J. Chanock, Julia Mayerle, William Greenhalf, Marta Flández, Federico Canzian, Markus M. Lerch, Xavier Molero, Roger L. Milne, Francisco X. Real, Miquel Porta, Jonas Rosendahl, Manolis Kogevinas, Nathaniel Rothman, David C. Whitcomb, Marianne Johnstone, Antoni Farré, and Laufey T. Amundadottir

Subjects
Mutation, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Haplotype, Gastroenterology, Mutagenesis (molecular biology technique), Promoter, Transfection, medicine.disease_cause, Molecular biology, Plasmid, Acinar cell, Medicine, Luciferase, business
Abstract

s / Pancreatology 15 (2015) S1eS141 S16 Materials & methods: SPINK1 promoter variants were constructed by site-directed mutagenesis and cloned into a luciferase reporter vector. Cells were transfected with the reporter plasmids and luciferase expression was then measured from the cell lysates. Results: We found that most variants caused relatively small changes in promoteractivity. Surprisingly, however,weobserved significantvariations in theeffectsof thepromotervariants inthedifferentcell lines.Only fourvariants exhibited consistently reduced promoter activity in all acinar cell lines, confirming previous reports that variants c.-108G>T, c.-142T>C, and c.-147A>G are risk factors for chronicpancreatitis and identifying c.-52G>Tas anovel risk variant. In contrast, variant c.-215G>A, which is linked with the diseaseassociated splice-site mutation c.194þ2T>C, caused increased promoter activity, which may mitigate the overall effect of the pathogenic haplotype. Conclusion: Our study lends further support to the notion that sequence evaluation of the SPINK1 promoter region in patients with chronic pancreatitis is justified as part of the etiological investigation.

Published
2015
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8. The PANcreatic disease ReseArch (PANDoRA) consortium: An update

Author

Claudio Bassi, George Theodoropoulos, Aldo Scarpa, Pierluigi Di Sebastiano, Eithne Costello, Cosmeri Rizzato, Federico Canzian, Angelo Andriulli, Barbara Pardini, Stefano Landi, Maurizio Cantore, Claudio Ricci, Sergio Pedrazzoli, Peter Bugert, Ugo Boggi, Gianfranco Delle Fave, Niccola Funel, Raffaele Pezzilli, Pavel Vodicka, Gabriele Capurso, Renata Talar-Wojnarowska, Daniele Campa, Pavel Soucek, John P. Neoptolemos, Jens Werner, Nathalia A. Giese, Markus W. Büchler, Claudio Pasquali, Maria Gazouli, and Juozas Kupcinskas

Subjects
Oncology, medicine.medical_specialty, Pancreatic disease, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Gastroenterology, medicine, business, medicine.disease
Published
2013
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9. Gene-wide association study on the TERT locus and PDAC susceptibility – Results from the PANDoRA consortium

Author

Roberto Valente, Nathalia A. Giese, Krzysztof Jamroziak, Pavel Vodicka, Stefano Landi, Jens Werner, Federico Canzian, Gabriele Capurso, Cosmeri Rizzato, William Greenhalf, Pezzilli, Renata Talar-Wojnarowska, Timothy J. Key, John P. Neoptolemos, K-T Khaw, Daniele Campa, Barbara Burwinkel, Pavel Soucek, Afshan Siddiq, Eithne Costello, Peter Bugert, Andrea Imbrogno, and M.W. Büchler

Subjects
Genetics, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Gastroenterology, Medicine, Locus (genetics), business, Gene
Published
2012
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10. Replication of seven pancreatic cancer loci identified in two Asian populations – Results from the PANDoRA consortium

Author

Cosmeri Rizzato, Dario Fabbri, John P. Neoptolemos, Peter Bugert, Gabriele Capurso, Afshan Siddiq, Jens Werner, Krzysztof Jamroziak, Timothy J. Key, Nathalia A. Giese, William Greenhalf, M.W. Büchler, Pavel Soucek, Stefano Landi, Barbara Burwinkel, K-T Khaw, G. Delle Fave, Eithne Costello, Renata Talar-Wojnarowska, Daniele Campa, Raffaele Pezzilli, Pavel Vodicka, and Federico Canzian

Subjects
Genetics, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Pancreatic cancer, Replication (statistics), Gastroenterology, Medicine, business, medicine.disease
Published
2012
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11. Genetic susceptibility to pancreatic cancer and its functional characterization: The PANcreatic Disease ReseArch (PANDoRA) consortium

Author

Renata Talar-Wojnarowska, Pavel Soucek, Jens Werner, Afshan Siddiq, John P. Neoptolemos, Timothy J. Key, Daniele Campa, Gabriele Capurso, Stefano Landi, Raffaele Pezzilli, K-T Khaw, G. Delle Fave, Nathalia A. Giese, Pavel Vodicka, Peter Bugert, Eithne Costello, Andrea Imbrogno, Krzysztof Jamroziak, M.W. Büchler, Barbara Burwinkel, William Greenhalf, Federico Canzian, and Cosmeri Rizzato

Subjects
Pancreatic disease, Hepatology, business.industry, Endocrinology, Diabetes and Metabolism, Pancreatic cancer, Gastroenterology, medicine, Genetic predisposition, medicine.disease, business, Bioinformatics
Published
2012
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