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Start Over Descriptor "Mosquito Flavivirus" Journal parasites & vectors
3 results on '"Mosquito Flavivirus"'

1. Field-captured Aedes vexans (Meigen, 1830) is a competent vector for Rift Valley fever phlebovirus in Europe

Author

Lotty Birnberg, Sandra Talavera, Carles Aranda, Ana I. Núñez, Sebastian Napp, and Núria Busquets

Subjects
Aedes vexans, RVFV, Mosquito Flavivirus, Vector competence, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Aedes vexans (Meigen) is considered a nuisance species in central Europe and the Mediterranean region. It is an anthropophilic and mammalophilic floodwater mosquito involved in the transmission of several arboviruses. Rift Valley fever (RVF) is a relevant mosquito-borne zoonosis, affecting mainly humans and ruminants, that causes severe impact in public health and economic loses. Due to globalization and climate change, the European continent is threatened by its introduction. The main purpose of the present study was to evaluate the vector competence of a European field-collected Ae. vexans population. Methods Aedes vexans field-collected larvae were reared in the laboratory under field-simulated conditions. To assess the vector competence for Rift Valley fever phlebovirus (RVFV) transmission, adult F0 females were exposed to infectious blood meals containing the 56/74 RVFV strain. Additionally, intrathoracic inoculations with the same virus strain were performed to evaluate the relevance of the salivary gland barriers. Natural circulation of alphavirus, flavivirus and phlebovirus was also tested. Results To our knowledge, an autochthonous Ae. vexans population was experimentally confirmed as a competent vector for RVFV for the first time. This virus was capable of infecting and disseminating within the studied Ae. vexans mosquitoes. Moreover, infectious virus was isolated from the saliva of disseminated specimens, showing their capacity to transmit the virus. Additionally, a natural infection with a circulating Mosquito flavivirus was detected. The co-infection with the Mosquito flavivirus seemed to modulate RVFV infection susceptibility in field-collected Ae. vexans, but further studies are needed to confirm its potential interference in RVFV transmission. Conclusions Our results show that field-collected European Ae. vexans would be able to transmit RVFV in case of introduction into the continent. This should be taken into consideration in the design of surveillance and control programmes.

Published
2019
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3. Field-captured Aedes vexans (Meigen, 1830) is a competent vector for Rift Valley fever phlebovirus in Europe

Author

Ana I. Núñez, Carles Aranda, Núria Busquets, Sandra Talavera, Sebastian Napp, Lotty Birnberg, Producció Animal, and Sanitat Animal

Subjects
0301 basic medicine, Phlebovirus, Rift Valley Fever, Rain, Aedes vexans, 0302 clinical medicine, Aedes, Zoonoses, Chlorocebus aethiops, Rift Valley fever, education.field_of_study, biology, Zoonosis, Ruminants, Specific Pathogen-Free Organisms, Europe, Flavivirus, Infectious Diseases, Mosquito Flavivirus, Female, 030231 tropical medicine, Population, Alphavirus, Mosquito Vectors, lcsh:Infectious and parasitic diseases, Cell Line, 03 medical and health sciences, medicine, Animals, Humans, lcsh:RC109-216, education, Saliva, Vero Cells, Research, RVFV, Water, medicine.disease, biology.organism_classification, Rift Valley fever virus, Virology, Floods, Clone Cells, 030104 developmental biology, Parasitology, Spain, Cattle, Vector competence, Chickens
Abstract

BackgroundAedes vexans(Meigen) is considered a nuisance species in central Europe and the Mediterranean region. It is an anthropophilic and mammalophilic floodwater mosquito involved in the transmission of several arboviruses. Rift Valley fever (RVF) is a relevant mosquito-borne zoonosis, affecting mainly humans and ruminants, that causes severe impact in public health and economic loses. Due to globalization and climate change, the European continent is threatened by its introduction. The main purpose of the present study was to evaluate the vector competence of a European field-collectedAe. vexanspopulation.MethodsAedes vexansfield-collected larvae were reared in the laboratory under field-simulated conditions. To assess the vector competence for Rift Valley fever phlebovirus (RVFV) transmission, adult F0 females were exposed to infectious blood meals containing the 56/74 RVFV strain. Additionally, intrathoracic inoculations with the same virus strain were performed to evaluate the relevance of the salivary gland barriers. Natural circulation of alphavirus, flavivirus and phlebovirus was also tested.ResultsTo our knowledge, an autochthonousAe. vexanspopulation was experimentally confirmed as a competent vector for RVFV for the first time. This virus was capable of infecting and disseminating within the studiedAe. vexansmosquitoes. Moreover, infectious virus was isolated from the saliva of disseminated specimens, showing their capacity to transmit the virus. Additionally, a natural infection with a circulating Mosquito flavivirus was detected. The co-infection with the Mosquito flavivirus seemed to modulate RVFV infection susceptibility in field-collectedAe. vexans, but further studies are needed to confirm its potential interference in RVFV transmission.ConclusionsOur results show that field-collected EuropeanAe. vexanswould be able to transmit RVFV in case of introduction into the continent. This should be taken into consideration in the design of surveillance and control programmes.

Published
2019

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