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Start Over Author "Stocchi, A." Journal parkinsonism & related disorders
117 results on '"Stocchi, A."'

2. Continuous subcutaneous levodopa/carbidopa infusion (ND0612) for patients with Parkinson’s disease and motor fluctuations: A Phase 3, active-controlled study (BouNDless)

Author

Stocchi, F., primary, Espay, A., additional, Albanese, A., additional, Ellenbogen, A., additional, Ferreira, J.J., additional, Giladi, N., additional, Gurevich, T., additional, Hassin-Baer, S., additional, Hernandez-Vara, J., additional, Isaacson, S., additional, Kieburtz, K., additional, LeWitt, P., additional, Lopez-Manzanares, L., additional, Olanow, C.W., additional, Pahwa, R., additional, Poewe, W., additional, Sarva, H., additional, Yardeni, T., additional, Adar, L., additional, Lopes, N., additional, Sasson, N., additional, Case, R., additional, and Rascol, O., additional

Published
2024
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7. Functional gait disorders: Demographic and clinical correlations

Author

Tinazzi, Michele, primary, Pilotto, Andrea, additional, Morgante, Francesca, additional, Marcuzzo, Enrico, additional, Cuoco, Sofia, additional, Ceravolo, Roberto, additional, Mazzucchi, Sonia, additional, Padovani, Alessandro, additional, Romito, Luigi Michele, additional, Eleopra, Roberto, additional, Nicoletti, Alessandra, additional, Dallocchio, Carlo, additional, Arbasino, Carla, additional, Bono, Francesco, additional, Magro, Giuseppe, additional, Demartini, Benedetta, additional, Gambini, Orsola, additional, Modugno, Nicola, additional, Olivola, Enrica, additional, Bonanni, Laura, additional, Zanolin, Elisabetta, additional, Albanese, Alberto, additional, Ferrazzano, Gina, additional, Tessitore, Alessandro, additional, Lopiano, Leonardo, additional, Calandra-Buonaura, Giovanna, additional, Petracca, Martina, additional, Esposito, Marcello, additional, Pisani, Antonio, additional, Manganotti, Paolo, additional, Tesolin, Lucia, additional, Teatini, Francesco, additional, Defazio, Giovanni, additional, Ercoli, Tommaso, additional, Stocchi, Fabrizio, additional, Erro, Roberto, additional, Zappia, Mario, additional, and Geroin, Christian, additional

Published
2021
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8. The spectrum of 'off' in Parkinson's disease: What have we learned over 40 years?

Author

Fabrizio Stocchi, Kelvin L. Chou, Mark Stacy, Tanya Simuni, Janis M. Miyasaki, Kapil D. Sethi, Wolfgang H. Oertel, and Hubert H. Fernandez

Subjects
0301 basic medicine, Parkinson's disease, Psychoanalysis, Parkinson Disease, medicine.disease, Motor function, Motor symptoms, Terminology, Antiparkinson Agents, Levodopa, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Neurology, medicine, Humans, Neurology (clinical), Geriatrics and Gerontology, Psychology, 030217 neurology & neurosurgery
Abstract

The terms "on" and "off" were used by Marsden and his contemporaries over 40 years ago to describe times when Parkinson's disease patients experienced good motor function ("on") and immobility ("off"). Yet there remains no published consensus definition of "off", leading clinicians and patients to develop individualized impressions of "off" determinations. In this paper, we first discuss the evolution of the terminology and understanding of "off" states since Marsden's time, which now include non-motor as well as motor symptoms. We then review pathophysiology and risk factors for the development of "off" states as well as tools to detect the "off" state, before proposing a practical definition of "off" for consideration. A common, practical definition of the "off" state could improve clinical recognition of "off" symptoms and lead to significant benefit for patients.

Published
2018

11. Validity of the wall goniometer as a screening tool to detect postural abnormalities in Parkinson's disease

Author

Tinazzi, Michele, primary, Gandolfi, Marialuisa, additional, Artusi, Carlo Alberto, additional, Lanzafame, Ruggero, additional, Zanolin, Elisabetta, additional, Ceravolo, Roberto, additional, Capecci, Marianna, additional, Andrenelli, Elisa, additional, Ceravolo, Maria Gabriella, additional, Bonanni, Laura, additional, Onofrj, Marco, additional, Telese, Roberta, additional, Bertolotti, Claudio, additional, Polverino, Paola, additional, Manganotti, Paolo, additional, Mazzucchi, Sonia, additional, Giannoni, Sara, additional, Vacca, Laura, additional, Stocchi, Fabrizio, additional, Casali, Miriam, additional, Zibetti, Maurizio, additional, Lopiano, Leonardo, additional, Fasano, Alfonso, additional, and Geroin, Christian, additional

Published
2019
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12. Effect of baseline dyskinesia on safety and efficacy of istradefylline, an A2A receptor antagonist, in Parkinson's disease: 8-study pooled analysis

Author

Nobutaka Hattori, Daniel D. Truong, Fabrizio Stocchi, P.M. Salzman, K. Toyama, J. Parno, Stuart Isaacson, Olivier Rascol, Akihisa Mori, and R. Ristuccia

Subjects
Oncology, medicine.medical_specialty, Parkinson's disease, business.industry, medicine.drug_class, Istradefylline, Receptor antagonist, medicine.disease, chemistry.chemical_compound, Pooled analysis, Neurology, chemistry, Dyskinesia, Internal medicine, medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Published
2020

13. BouNDless: An active-controlled, randomised, double-blind, double-dummy trial of continuous subcutaneous infusion of levodopa/carbidopa with ND0612 in patients with Parkinson's disease

Author

Werner Poewe, S. Leibman Barak, T. Yardeni, Fabrizio Stocchi, O. Rosenfeld, C. W. Olanow, Liat Adar, and O. Rascol

Subjects
Double blind, Parkinson's disease, Neurology, business.industry, Anesthesia, Levodopa carbidopa, medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, medicine.disease, business, Continuous subcutaneous infusion
Published
2020

14. The burden of non-motor symptoms in Parkinson's disease using a self-completed non-motor questionnaire: A simple grading system

Author

Kapil D. Sethi, Kalyan Bhattacharya, Kazuo Abe, Alexandra Rizos, K. Ray Chaudhuri, Carmen Rodriguez-Blazquez, Jose Manuel Rojo, Fabrizio Stocchi, Yoshio Tsuboi, Angelo Antonini, Pablo Martinez-Martin, Anna Sauerbier, Anthony H.V. Schapira, Per Odin, and Richard G. Brown

Subjects
Adult, Male, Self-Assessment, medicine.medical_specialty, Parkinson's disease, Neurology, International Cooperation, Disease, Anxiety, Rating scale, Surveys and Questionnaires, medicine, Humans, Grading (education), Aged, Aged, 80 and over, Depression, business.industry, Parkinson Disease, Middle Aged, medicine.disease, Clinical neurology, Cross-Sectional Studies, Quality of Life, Physical therapy, Non motor, Female, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Abstract

Non-motor symptoms (NMS) of Parkinson's disease (PD) affect virtually every patient, yet they are under-recognized and under-treated. The NMS Questionnaire (NMSQuest) is a validated 30-item self-assessment instrument useful for NMS screening in clinic.Development of a straight forward grading classification of the burden of non-motor symptoms in PD based on the number of NMS as assessed by the NMS Questionnaire.In an observational, cross-sectional, international study of 383 consecutive patients distribution of the declared NMS as per NMSQuest was analyzed according to previously published levels based on the Non-Motor Symptoms Scale and also the median and interquartile range (IR, percentiles 25 and 75) of the total NMSQuest scores. After post hoc checking, these values were proposed as cut-off points for estimating NMS burden based only on the accumulation of symptoms.Burden and number of NMS correlate closely (r ≥ 0.80). On the basis of this finding, five levels (0 = No NMS to 4 = Very severe) of NMSQuest grading were proposed after identification of their cut-offs by ordinal logistic regression and median and interquartile range distribution. These values coincided almost completely with those obtained by median and interquartile range in an independent sample. Concordance between this classification and HY staging was weak (weighted kappa = 0.30), but was substantial (weighted kappa = 0.68) with the Non-Motor Symptoms Scale grading.Completion of NMSQuest and subsequent grading of the burden could allow the health care professional to approach the severity of NMS burden using the self completed NMSQuest in a primary care setting.

Published
2015

16. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease

Author

Fabrizio Stocchi

Subjects
Dyskinesia, Drug-Induced, Levodopa, Parkinson's disease, Dopamine, Stimulation, Drug Administration Schedule, Antiparkinson Agents, chemistry.chemical_compound, medicine, Animals, Humans, MPTP, Dopaminergic, Parkinson Disease, medicine.disease, nervous system diseases, Disease Models, Animal, Ropinirole, Neurology, chemistry, Neurology (clinical), Geriatrics and Gerontology, Psychology, Neuroscience, medicine.drug
Abstract

Continuous dopaminergic stimulation is a therapeutic concept for the management of Parkinson's disease (PD) that proposes that continuous, as opposed to discontinuous or pulsatile, stimulation of striatal dopamine receptors will delay or prevent the onset of levodopa-related motor complications. This hypothesis has arisen from studies of the normal basal ganglia demonstrating that nigral dopaminergic neurons normally fire continuously and striatal dopamine levels are relatively constant. In MPTP monkeys, pulsatile stimulation of striatal dopamine receptors with short-acting agents is associated with the induction of molecular and physiologic changes in basal ganglia neurons and the development of motor complications. These are avoided when dopaminergic therapies are delivered in a more continuous manner. Studies in animal models support this hypothesis, demonstrating that long-acting dopamine agonists are associated with a decreased risk of motor complications in comparison to short-acting formulations of levodopa. Similarly, continuous infusion of dopamine agonists ropinirole and rodigotine reduces dyskinesia associated with intermittent doses of oral formulations of the same drug. The current challenge is to develop a long-acting formulation of levodopa that simulates the pharmacokinetic pattern seen with infusions of levodopa in attempt to provide comparable benefits with an oral levodopa treatment strategy.

Published
2009

17. The hypothesis of the genesis of motor complications and continuous dopaminergic stimulation in the treatment of Parkinson's disease

Author

Fabrizio Stocchi

Subjects
Levodopa, Movement Disorders, Time Factors, Parkinson's disease, Dopamine Agents, Dopaminergic, Parkinson Disease, Stimulation, Disease, medicine.disease, Neurology, Dopamine receptor, Basal ganglia, medicine, Animals, Humans, Neurology (clinical), Geriatrics and Gerontology, Psychology, Receptor, Neuroscience, medicine.drug
Abstract

The symptoms of Parkinson's disease can become increasingly difficult to control as the disease advances. Levodopa remains the most efficacious therapy for symptomatic treatment. However, with long-term therapy motor and non-motor complications develop. There is now accumulating evidence that several factors - the progressive pathology of Parkinson's disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors - are key contributors to the priming of the basal ganglia for induction of motor complications. In this paper, an overview of the different factors inducing motor fluctuations and the role of dopamine receptors stimulation is provided.

Published
2009

18. The worse is the clinical status of the patient with Parkinson, the higher is the stride length percentage of improvement after Automated Mechanical Peripheral Stimulation

Author

Maria Francesca De Pandis, Maria Gaglione, Patrizio Sale, Giorgio Albertini, Ana Francisca Rozin Kleiner, Fabrizio Stocchi, Daniela Hildebrand, and Manuela Galli

Subjects
medicine.medical_specialty, Physical medicine and rehabilitation, Neurology, business.industry, Physical therapy, Medicine, Neurology (clinical), Stride length, Geriatrics and Gerontology, business, Peripheral stimulation
Published
2016

20. Corrigendum to “Early detection of wearing off in Parkinson disease: The DEEP study” [Parkinsonism Relat Disorder 20 (2014) 204–211]

Author

Stocchi, F., primary, Antonini, A., additional, Barone, P., additional, Tinazzi, M., additional, Zappia, M., additional, Onofrj, M., additional, Ruggieri, S., additional, Morgante, L., additional, Bonuccelli, U., additional, Lopiano, L., additional, Pramstaller, P., additional, Albanese, A., additional, Attar, M., additional, Posocco, V., additional, Colombo, D., additional, and Abbruzzese, G., additional

Published
2015
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21. Prevalence and associated features of self-reported freezing of gait in Parkinson disease: The DEEP FOG study

Author

Amboni, M., primary, Stocchi, F., additional, Abbruzzese, G., additional, Morgante, L., additional, Onofrj, M., additional, Ruggieri, S., additional, Tinazzi, M., additional, Zappia, M., additional, Attar, M., additional, Colombo, D., additional, Simoni, L., additional, Ori, A., additional, Barone, P., additional, and Antonini, A., additional

Published
2015
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22. The burden of non-motor symptoms in Parkinson's disease using a self-completed non-motor questionnaire: A simple grading system

Author

Chaudhuri, K. Ray, primary, Sauerbier, A., additional, Rojo, J.M., additional, Sethi, K., additional, Schapira, A.H.V., additional, Brown, R.G., additional, Antonini, A., additional, Stocchi, F., additional, Odin, P., additional, Bhattacharya, K., additional, Tsuboi, Y., additional, Abe, K., additional, Rizos, A., additional, Rodriguez-Blazquez, Carmen, additional, and Martinez-Martin, P., additional

Published
2015
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24. Corrigendum to 'Early detection of wearing off in Parkinson disease: The DEEP study' [Parkinsonism Relat Disorder 20 (2014) 204–211]

Author

Mario Zappia, Ubaldo Bonuccelli, Marco Onofrj, Giovanni Abbruzzese, Leonardo Lopiano, Alberto Albanese, Fabrizio Stocchi, Angelo Antonini, Peter P. Pramstaller, Serena Ruggieri, V. Posocco, Michele Tinazzi, Letterio Morgante, Paolo Barone, Mahmood Attar, and Delia Colombo

Subjects
Neurology, business.industry, Parkinsonism, medicine, Early detection, Neurology (clinical), Geriatrics and Gerontology, medicine.disease, business, Humanities, Medical care, Medical department
Abstract

a Department of Neurology, Institute of Research and Medical Care, IRCCS San Raffaele, Rome, Italy b Department for Parkinson's Disease, IRCCS San Camillo, Venice, Italy c School of Medicine, University of Salerno, Salerno, Italy d U.O. Neurologia Ospedale Civile Maggiore, Borgo Trento, Verona, Italy e Clinica Neurologica I Policlinico Universitario, Catania, Italy f CeSI-Centro Studi Invecchiamento Fondazione Universit a Gabriele D'Annunzio, Chieti, Italy g Neurologia Istituto Mediterraneo Neuromed, Isernia, Italy h Dipartimento di Neuroscienze Universit a di Messina, Messina, Italy i U.O. Neurologia Ospedale Versilia, Lucca, Italy j Neurologia 4 A.S.O. Molinette, Turin, Italy k Neurologia Ospedale di Bolzano, Bolzano, Italy l Neurologia I Istituto Nazionale Neurologico C. Besta, Universit a Cattolica del Sacro Cuore, Milan, Italy m Novartis Pharma Italia, Medical Department, Origgio, Italy n Department of Neurosciences, University of Genoa, Genoa, Italy

Published
2015

25. Characterizing motor and non-motor aspects of early-morning off periods in Parkinson's disease: An international multicenter study

Author

Rizos, A., primary, Martinez-Martin, P., additional, Odin, P., additional, Antonini, A., additional, Kessel, B., additional, Kozul, T. Klemencic, additional, Todorova, A., additional, Douiri, A., additional, Martin, A., additional, Stocchi, F., additional, Dietrichs, E., additional, and Chaudhuri, K. Ray, additional

Published
2014
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26. Early DEtection of wEaring off in Parkinson disease: The DEEP study

Author

Stocchi, F., primary, Antonini, A., additional, Barone, P., additional, Tinazzi, M., additional, Zappia, M., additional, Onofrj, M., additional, Ruggieri, S., additional, Morgante, L., additional, Bonuccelli, U., additional, Lopiano, L., additional, Pramstaller, P., additional, Albanese, A., additional, Attar, M., additional, Posocco, V., additional, Colombo, D., additional, and Abbruzzese, G., additional

Published
2014
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27. 2.268 FIRST 2-YEAR, PLACEBO-CONTROLLED STUDY IN PARKINSON'S DISEASE PATIENTS WITH MOTOR FLUCTUATIONS INDICATES SAFINAMIDE MAY BENEFIT PATIENTS WITH MORE SEVERE DYSKINESIA

Author

P. Rice, Rupam Borgohain, R. Guiliani, R. Anand, Fabrizio Stocchi, E. Forrest, and V. Lucini

Subjects
Safinamide, medicine.medical_specialty, Parkinson's disease, business.industry, Placebo-controlled study, medicine.disease, chemistry.chemical_compound, Neurology, chemistry, Dyskinesia, Internal medicine, Medicine, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, business
Published
2012

33. 2.267 LONG-TERM EFFICACY OF SAFINAMIDE AS ADD-ON TO LEVODOPA IN PARKINSON'S DISEASE (PD) USING AN ‘ON’ AND ‘ON-OFF’ TREATMENT ANALYSIS

Author

V. Lucini, Rupam Borgohain, Mohit Bhatt, D. Chirileanu, R. Anand, and Fabrizio Stocchi

Subjects
Safinamide, Levodopa, medicine.medical_specialty, Parkinson's disease, business.industry, medicine.disease, Term (time), chemistry.chemical_compound, Physical medicine and rehabilitation, Neurology, chemistry, medicine, Neurology (clinical), Geriatrics and Gerontology, Off Treatment, business, medicine.drug
Published
2012

47. P2.166 Once-daily ropinirole prolonged release improves activities of daily living and motor symptoms in patients with advanced Parkinson's disease

Author

L. Giorgi, C.B. Rockett, K. Rolfe, and F. Stocchi

Subjects
medicine.medical_specialty, Activities of daily living, Parkinson's disease, business.industry, medicine.disease, Motor symptoms, Ropinirole, Neurology, Prolonged release, Physical therapy, Medicine, In patient, Neurology (clinical), Geriatrics and Gerontology, Once daily, business, medicine.drug
Published
2009

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