1. Sleep disturbances and brain MRI morphometry in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy - a comparative study
- Author
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Veralice M. de Bruin, Cruiff E. Silva, Rômulo Lopes Gama, Pedro Felipe Carvalhedo de Bruin, Rodrigo C. Bomfim, and Daniel Gurgel Fernandes Távora
- Subjects
Sleep Wake Disorders ,medicine.medical_specialty ,Parkinson's disease ,Excessive daytime sleepiness ,Progressive supranuclear palsy ,Pittsburgh Sleep Quality Index ,Atrophy ,Internal medicine ,mental disorders ,medicine ,Humans ,Restless legs syndrome ,Epworth Sleepiness Scale ,Parkinson Disease ,Multiple System Atrophy ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,nervous system diseases ,Obstructive sleep apnea ,Cross-Sectional Studies ,Neurology ,Cardiology ,Physical therapy ,Neurology (clinical) ,Supranuclear Palsy, Progressive ,Geriatrics and Gerontology ,medicine.symptom ,Psychology - Abstract
Despite common reports in Parkinson's disease (PD), in other parkinsonian syndromes, sleep disturbances have been less frequently described. This study evaluated and compared sleep disturbances in patients with PD, multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and analyzed associations with brain magnetic resonance imaging (MRI) morphometry. This was a cross-sectional study of 16 PD cases, 13 MSA, 14 PSP and 12 control. Sleep disturbances were evaluated by Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (PSQI), Restless Legs Scale and Berlin questionnaire. Pons area, midbrain area, medial cerebellar peduncle (MCP) width, and superior cerebellar peduncle width were measured using MRI. Poor quality sleep, risk of obstructive sleep apnea (OSA) and restless legs syndrome (RLS) were detected in all groups. Patients with MSA showed higher risk of OSA and less frequent RLS. In MSA, a correlation between PSQI scores and Hoehn and Yahr stage was observed (p
- Published
- 2009