1. Aspirin plus ticlopidine prevented experimental endocarditis due toEnterococcus faecalisandStreptococcus gallolyticus
- Author
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Stefano Mancini, Tiago Rafael Veloso, José M. Entenza, Philippe Moreillon, Frank Oechslin, and Yok-Ai Que
- Subjects
Microbiology (medical) ,Ticlopidine ,Animals ,Aspirin/administration & dosage ,Disease Models, Animal ,Endocarditis, Bacterial/microbiology ,Endocarditis, Bacterial/prevention & control ,Enterococcus faecalis/growth & development ,Female ,Gram-Positive Bacterial Infections/microbiology ,Gram-Positive Bacterial Infections/prevention & control ,Platelet Aggregation Inhibitors/pharmacology ,Rats, Wistar ,Streptococcus/growth & development ,Ticlopidine/administration & dosage ,Treatment Outcome ,Short Communication ,Context (language use) ,medicine.disease_cause ,Enterococcus faecalis ,Microbiology ,medicine ,Immunology and Allergy ,Endocarditis ,Streptococcus gallolyticus ,Gram-Positive Bacterial Infections ,Aspirin ,General Immunology and Microbiology ,biology ,Streptococcus ,Endocarditis, Bacterial ,General Medicine ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Infective endocarditis ,Platelet aggregation inhibitor ,Platelet Aggregation Inhibitors ,medicine.drug - Abstract
Enterococcus faecalis and Streptococcus gallolyticus cause infective endocarditis (IE), which can originate from the continuous release or translocation of low bacterial numbers into the bloodstream. In this context, IE cannot be prevented with antibiotics. We previously demonstrated that aspirin plus ticlopidine protected rats from IE due to S. gordonii and Staphylococcus aureus. Here we showed that aspirin plus ticlopidine significantly reduced vegetation weight and protected 73 and 64% rats (P < 0.005) from IE due to E. faecalis and S. gallolyticus, respectively. These results further support the potential use of aspirin plus ticlopidine for a global prevention of IE in high-risk patients.
- Published
- 2015