1. Expression and prognostic significance of VEGFR-2 in breast cancer.
- Author
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Yan, Ji-Dong, Liu, Yanrong, Zhang, Zhi-Yong, Liu, Guang-Yin, Xu, Jin-Heng, Liu, Li-Yun, and Hu, Yue-Ming
- Subjects
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VASCULAR endothelial growth factor receptors , *BREAST cancer prognosis , *PROTEIN expression , *CADHERINS , *METASTASIS , *IMMUNOHISTOCHEMISTRY , *PROGNOSIS - Abstract
Breast cancer is one of the most common cancers among women in the world. Vascular endothelial growth factor receptor 2 (VEGFR-2) was not only found to play a key role in the development of tumor angiogenesis, but has also been located in tumor cells of a variety of tumors. This study investigated the expression pattern of VEGFR-2 in breast cancer tissue specimens in order to evaluate the role of VEGFR-2 in the prognosis of breast cancer. Expression and localization of VEGFR-2 in tumor cells of breast cancer specimens from 98 invasive breast cancer patients were determined by immunohistochemistry. The relationships between VEGFR-2 expression and clinicopathological features were also analyzed. The results showed that VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer. Patients with high expression of VEGFR-2 had a significantly worse OS. It was also observed that the expression of epithelial-mesenchymal transition (EMT) marker, including Twist1 and Vimentin, was higher in the tumors with higher VEGFR-2 expression, while the E-cadherin expression was lower in the same tumors, suggesting that VEGFR-2 may serve as a possible mediator of EMT in breast cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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