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Your search keyword '"John F. Kuttesch"' showing total 2 results
Start Over Author "John F. Kuttesch" Journal pediatric bloodcancer
2 results on '"John F. Kuttesch"'

1. A quantitative meta-analysis of neurocognitive sequelae in survivors of pediatric brain tumors

Author

Jennifer E. Champion, Dana W. Hipp, Charissa Andreotti, Alexandra H. Bettis, John F. Kuttesch, Kristen E. Robinson, Anna S. Barnwell, and Bruce E. Compas

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Brain Neoplasms, Brain tumor, Hematology, Neuropsychological Tests, medicine.disease, Blood cancer, Oncology, Pediatric brain, Meta-analysis, Pediatrics, Perinatology and Child Health, Medicine, Humans, Survivors, business, Psychiatry, Child, Cognition Disorders, Neurocognitive, Psychomotor Performance
Abstract

Background Deficits in neurocognitive functioning are an important area of late effects in survivors of pediatric brain tumors, but a quantitative analysis of the magnitude of these deficits has yet to be conducted. Procedure The purpose of the current article is to provide a comprehensive meta-analysis of the literature on long-term neurocognitive effects found in these survivors. Results Results indicated significant deficits in both narrow and broad indices of neurocognitive functioning, and the overall magnitude of the effects across all domains ranged from small to large in magnitude (g = −0.45 to −1.43) with a large mean overall effect size of g = −0.91. Conclusions These findings underscore the importance of monitoring the neurocognitive late effects in survivors of pediatric brain tumors, and the need for more consistent consideration of demographic, diagnostic, and treatment-related variables in future research to allow for examination of factors that may moderate these deficits. Pediatr Blood Cancer. 2010;55:525–531. © 2010 Wiley-Liss, Inc.

Published
2010

2. Flow cytometry and fluorescence in situ hybridization to detect residual neuroblastoma cells in bone marrow

Author

John F. Kuttesch, Carlos E. Bueso-Ramos, Ka Wah Chan, Douglas A. Weidner, Alp Ozkan, Michael Andreeff, Heidi V. Russell, Rui-Yu Wang, Joann L. Ater, Mph Mehmet Fatih Okcu Md, Wendy D. Schober, Richard J. Andrassy, and Martin L. Blakely

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Neoplasm, Residual, Adolescent, Population, In situ hybridization, Sensitivity and Specificity, Flow cytometry, Immunophenotyping, Neuroblastoma, Antigen, Antigens, CD, Bone Marrow, medicine, Humans, education, Child, In Situ Hybridization, Fluorescence, Chromosome Aberrations, education.field_of_study, medicine.diagnostic_test, business.industry, Infant, Bone Marrow Examination, Hematology, Flow Cytometry, Molecular biology, Minimal residual disease, medicine.anatomical_structure, Oncology, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, Bone marrow, business, Fluorescence in situ hybridization, Chromosomes, Human, Pair 17
Abstract

Background In patients with neuroblastoma morphological assessment of BM for residual NB cells is not precise, particularly when the number of tumor cells is small. Procedure To develop a sensitive and rapid method of detecting NB cells in BM, we assessed the efficiency of flow cytometry (FCM) using markers CD9, CD56, and CD45. The percent of CD9+/CD56+/CD45− (NB phenotype) cells was determined by FCM in 41 samples (16 patients) at various time points. For confirmation fluorescence in situ hybridization (FISH) for 17q gain was performed. Results Nineteen of the 22 (86%) samples that were negative by morphology were positive by FCM (>0.006% CD9+/CD56+/CD45− cells). The longest time to complete the FCM study was 3 hr. In six FISH experiments the sorted CD9+/CD56+/CD45− population had a higher percentage of cells with 17q gain (11.5–95%) compared to a CD56−/CD45+ internal control population (2–8%). Conclusions Our preliminary results suggest that FCM determination of the percent of CD9+/CD56+/CD45− cells is an effective method of rapidly detecting NB cells in BM. © 2005 Wiley-Liss, Inc.

Published
2005

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