1. Low lymphocyte count: A clinical severity marker in infants with bronchiolitis
- Author
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Luigi Matera, Raffaella Nenna, Antonella Frassanito, Laura Petrarca, Enrica Mancino, Valentina Rizzo, Greta Di Mattia, Domenico Paolo La Regina, Alessandra Pierangeli, and Fabio Midulla
- Subjects
Hospitalization ,Pulmonary and Respiratory Medicine ,Pediatrics, Perinatology and Child Health ,Bronchiolitis ,Humans ,Infant ,Lymphocytes ,Respiratory Syncytial Virus Infections ,Child ,Respiratory Sounds ,Retrospective Studies - Abstract
Bronchiolitis is the most frequent cause of hospitalization in infants younger than 1 year of age. We sought to evaluate the correlation between lymphocyte count and clinical manifestation in infants hospitalized with bronchiolitis.We performed a retrospective cohort study evaluating 1297 children hospitalized for bronchiolitis from 2004 to 2019. A nasal washing was tested for 14 respiratory viruses by PCR. A clinical severity score, ranging 0-8, was assigned at hospital admission. History and clinical course were recorded for each infant. Patients were divided in 3 groups according to lymphocyte count tertiles. Parents of enrolled patients have been phoned annually over 5 years to evaluate respiratory sequelae.A total of 433 children had 2914.2 ± 745.5/mmInfants with low lymphocyte count are more likely to have a worse clinical course of bronchiolitis.
- Published
- 2022
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