1. Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness
- Author
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Jose J, Gil-Cosano, Luis, Gracia-Marco, Esther, Ubago-Guisado, Idoia, Labayen, Mireia, Adelantado-Renau, Cristina, Cadenas-Sanchez, Jose, Mora-Gonzalez, Abel, Plaza-Florido, Concepción M, Aguilera, José, Gómez-Vida, José, Maldonado, Jaak, Jürimäe, and Francisco B, Ortega
- Subjects
Male ,Pediatric Obesity ,Age Factors ,Absorptiometry, Photon ,Cross-Sectional Studies ,Bone Density ,Physical Fitness ,Exercise Test ,Humans ,Female ,Inflammation Mediators ,Child ,Muscle, Skeletal ,Biomarkers - Abstract
To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.Plasma interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), epidermal growth factor, vascular endothelial growth factor A (VEGF), and C-reactive protein were analyzed in 55 children aged 8-11 years. A muscular fitness score was computed. Bone mineral content (BMC) of the total body-less head (TBLH) and lumbar spine (LS) were assessed using dual-energy x-ray absorptiometry.IL-6 (β = -0.136) and VEGF (β = -0.099) were associated with TBLH BMC, while TNF-α (β = -0.345) and IL-1β (β = 0.212) were associated with LS BMC (P 0.05). The interaction effect of muscular fitness showed a trend in the association of VEGF with TBLH BMC (P = 0.122) and TNF-α with LS BMC (P = 0.057). Stratified analyses by muscular fitness levels showed an inverse association of VEGF with TBLH BMC (β = -0.152) and TNF-α with LS BMC (β = -0.491) in the low-fitness group, while no association was found in the high-fitness group.IL-6, VEGF, TNF-α, and IL-1β are significantly associated with bone mass. Higher muscular fitness may attenuate the adverse effect of high VEGF and TNF-α on bone mass.
- Published
- 2019