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Start Over Author "Neu, Josef" Journal pediatric research
31 results on '"Neu, Josef"'

23. Comparative Effects of Glucocorticoids and Prostaglandins on Small Intestine of Infant Rats

Author

Neu, Josef, Crim, Wendell N, and Hodge, Nancy C

Abstract

ABSTRACT. Previous studies have suggested similarities between the effects of exogenously administered glucocorticoids and prostaglandins in the developing rat small intestine. In this study the effects of exogenously administered glucocorticoids and prostaglandins were compared. In addition, the effects of prostaglandins in adrenalectomized rats were evaluated. Members of both classes of compounds stimulate small intestinal disaccharidase activities, and increase RNA to DNA ratio and brush border membrane protein synthesis. Hydrocortisone accelerates enterocyte turnover, whereas prostacyclin does not. Enteral administration of 16, 16-dimethyl prostaglandinE2stimulates disaccharidase activities in intact as well as shamoperated and adrenalectomized animals. The data suggest that certain prostaglandins may play a role in small intestinal metabolism which is similar to that of the glucocorticoids but is independent of the adrenal-intestinal axis.

Published
1986
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24. Glucocorticoid-Mediated Alteration of Fluidity of Brush Border Membrane in Rat Small Intestine

Author

Neu, Josef, Ozaki, Charles K, and Angelides, Kimon J

Abstract

ABSTRACT. The normal biophysical properties of the maturing mammalian enterocyte membrane are poorly understood. While the effects of glucocorticoids on maturation of intestinal enzyme function has been intensively investigated, their effects on membrane biophysical properties are not known. We used l,6-diphenyl-l,3,5-hexatriene as a probe in fluorescence anisotropy studies to determine the fluidity of rat brush border membrane. Maturational changes and the effects of glucocorticoids administered antenatally or postnatally were determined. Fluorescence anisotropy values for l,6-diphenyl-l,3,5-hexatriene in mature brush border membranes were higher than those values in membranes obtained from younger animals reflecting a less fluid membrane. Glucocorticoids administered to suckling rats increased the anisotropy values of l,6-diphenyl-l,3,5-hexatriene in the membranes compared to saline-administered littermates. The anisotropy of intestinal brush border membrane was also increased in fetal rats whose mothers received dexamethasone. These alterations may relate to protein-binding properties and permeability characteristics of the enterocyte membrane.

Published
1986
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