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The article informs that biliary atresia, and its sister nemesis neonatal hepatitis, have been recognized as common causes of neonatal cholestasis for many years. Thirty years ago, the clinical description of idiopathic neonatal hepatitis was assigned to nearly 40% of infants with neonatal cholestasis. Over the last three decades of discovery, identification of patients with alpha-1 antityrpsin deficiency, neonatal iron storage disease, the family of disorders associated with progressive familial intrahepatic cholestasis, and newer viral infections such as parvovirus and HHV6 have whittled the diagnosis of idiopathic neonatal hepatitis to less than 20% of cases of neonatal cholestasis.