1. Impact of a 16-Community Trial to Promote Judicious Antibiotic Use in Massachusetts
- Author
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Finkelstein, Jonathan A, Huang, Susan S, Kleinman, Ken, Rifas-Shiman, Sheryl L, Stille, Christopher J, Daniel, James, Schiff, Nancy, Steingard, Ron, Soumerai, Stephen B, Ross-Degnan, Dennis, Goldmann, Donald, and Platt, Richard
- Subjects
Health Services ,Pediatric ,Prevention ,Clinical Trials and Supportive Activities ,Clinical Research ,Adolescent ,Age Factors ,Anti-Bacterial Agents ,Child ,Child ,Preschool ,Cluster Analysis ,Drug Prescriptions ,Drug Resistance ,Microbial ,Drug Utilization ,Female ,Health Education ,Humans ,Incidence ,Male ,Massachusetts ,Probability ,Reference Values ,Respiratory Tract Infections ,Risk Assessment ,Severity of Illness Index ,Sex Factors ,antibiotic use ,parental knowledge ,randomized trial ,Antibiotic use ,Parental knowledge ,Randomized trial ,antibiotic agent ,adult ,article ,behavior change ,clinical practice ,clinical trial ,community ,controlled clinical trial ,controlled study ,drug use ,female ,human ,male ,medicaid ,normal human ,outcome assessment ,patient education ,physician attitude ,practice guideline ,prescription ,primary medical care ,priority journal ,randomized controlled trial ,United States ,Intervention Studies ,Prescriptions ,Drug ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Pediatrics - Abstract
ObjectivesReducing unnecessary antibiotic use, particularly among children, continues to be a public health priority. Previous intervention studies have been limited by size or design and have shown mixed results. The objective of this study was to determine the impact of a multifaceted, community-wide intervention on overall antibiotic use for young children and on use of broad-spectrum agents. In addition, we sought to compare the intervention's impact on commercially and Medicaid-insured children.MethodsWe conducted a controlled, community-level, cluster-randomized trial in 16 nonoverlapping Massachusetts communities, studied from 1998 to 2003. During 3 years, we implemented a physician behavior-change strategy that included guideline dissemination, small-group education, frequent updates and educational materials, and prescribing feedback. Parents received educational materials by mail and in primary care practices, pharmacies, and child care settings. Using health-plan data, we measured changes in antibiotics dispensed per person-year of observation among children who were aged 3 to
- Published
- 2008