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3. In vitro activity of the synthetic lipopeptide PAL-Lys-Lys-NH(2) alone and in combination with antifungal agents against clinical isolates of Cryptococcus neoformans.

Author

Barchiesi F, Giacometti A, Cirioni O, Arzeni D, Silvestri C, Kamysz W, Abbruzzetti A, Riva A, Kamysz E, and Scalise G

Subjects
Amphotericin B administration & dosage, Antifungal Agents administration & dosage, Antimicrobial Cationic Peptides administration & dosage, Antimicrobial Cationic Peptides pharmacology, Cryptococcus neoformans isolation & purification, Dipeptides administration & dosage, Drug Synergism, Fluconazole administration & dosage, Humans, In Vitro Techniques, Microbial Sensitivity Tests, Antifungal Agents pharmacology, Cryptococcus neoformans drug effects, Dipeptides pharmacology
Abstract

The in vitro activity of the lipopeptide PAL-Lys-Lys-NH(2) (PAL), alone or combined with either fluconazole (FLU) or amphotericin B (AMB), was investigated against 14 Cryptococcus neoformans isolates. PAL MICs ranged from 1.0 to 4.0 microg/ml. Fungicidal activity was observed. Synergy, defined as a fractional inhibitory concentration (FIC) index of < or =0.5, was observed in 21.4% of PAL/AMB interactions. Antagonism (FIC index>4) was never observed. The broad antifungal activity and the positive interactions with AMB suggest that PAL can represent a promising candidate in infections due to C. neoformans.

Published
2007
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