1. Caerulein in the treatment of biliary and renal colic
- Author
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F. Apuzzo, F. Ziller, M. Bezza, R. Mezzena, G. Bertagnolli, C. Graiff, B. Stringari, and R. Brentari
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Colic ,Physiology ,Biliary Tract Diseases ,Analgesic ,Biliary colic ,digestive system ,Biochemistry ,Gastroenterology ,Cellular and Molecular Neuroscience ,Endocrinology ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Renal colic ,Aged ,Common bile duct ,business.industry ,Bile duct ,digestive, oral, and skin physiology ,Middle Aged ,digestive system diseases ,surgical procedures, operative ,medicine.anatomical_structure ,Sphincter ,Female ,Kidney Diseases ,medicine.symptom ,business ,Common bile duct dilatation ,Ceruletide - Abstract
A randomized controlled study has been carried out in order to check the activity of caerulein in the treatment of biliary and renal colic. In 88% out of 107 patients caerulein, 1 ng/kg IV, relieved biliary colic and had no side effects. To elucidate the mechanism of action of the peptide, 22 cholecystectomized patients, showing a dilatation of the common bile duct (CBD), were submitted to caerulein treatment under echo-control. Reduction of CBD caliber was noticed when the dilatation was due to functional obstruction, whereas an organic obstruction of the terminal tract of CBD was found in the non-responding patients. Caerulein appears to be an effective agent in relieving biliary colic through a relaxation of Oddi's sphincter, and may be used in ultrasound differential diagnostics of terminal bile duct obstruction. Caerulein, 75 ng/kg intramuscularly, relieved renal colic in 75% of the examined patients; it is suggested that the effect of caerulein in this syndrome is due to central analgesic action.
- Published
- 1985
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