1. ABCA1, from pathology to membrane function
- Author
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Ana Zarubica, Doriane Trompier, Giovanna Chimini, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physiology ,Clinical Biochemistry ,Receptors, Cytoplasmic and Nuclear ,ATP-binding cassette transporter ,Models, Biological ,Cell membrane ,Mice ,Physiology (medical) ,Lipid translocation ,Cyclic AMP ,polycyclic compounds ,medicine ,ABCA1 Gene ,Animals ,Humans ,Liver X receptor ,Tangier Disease ,Liver X Receptors ,biology ,Reverse cholesterol transport ,hemic and immune systems ,Lipid Metabolism ,Orphan Nuclear Receptors ,Cell biology ,DNA-Binding Proteins ,Retinoid X Receptors ,ATP Binding Cassette Transporter 1 ,medicine.anatomical_structure ,Biochemistry ,ABCA1 ,biology.protein ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Cytokines ,ATP-Binding Cassette Transporters ,lipids (amino acids, peptides, and proteins) ,Protein Processing, Post-Translational - Abstract
The ABCA1 transporter is the prototype of the A class of mammalian adenosine triphosphate binding cassette transporters and one of the largest members of this family. ABCA1 has been originally identified as an engulfment receptor on macrophages and, more recently, it has been shown to play an essential role in the handling of cellular lipids. Indeed by promoting the effluxes of membrane phospholipids and cholesterol to lipid-poor apoprotein acceptors, ABCA1 controls the formation of high-density lipoproteins and thus the whole process of reverse cholesterol transport. A number of additional phenotypes have been found in the mouse model of invalidation of the ABCA1 gene. In spite of their clinical diversity, they all are extremely sensitive to variations in the physicochemical properties of the cell membrane, which ABCA1 controls as a lipid translocator.
- Published
- 2006
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