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Objective: To investigate the protective effects of Ficus tsiangii extracts on oxidative injuries of endothelial cells by H2O2,anti-oxidant activity in vitro and anti-platelet aggregation activity. Methods: Endothelial cells were incubated with F. tsiangii extracts for 1 h, and then were exposed to 150 µmol/L H2O2 for 4 h to induce oxidative injuries. Cell viability was determined by MTT assay. The antioxidant activity of F. tsiangii extracts in vitro was evaluated by a cell-free oxidation reaction. Anti-platelet aggregation activity of F. tsiangii extracts was assayed in the Born turbidimetric method using adenosine diphosphate(ADP) and platelet-activating factor (PAF) as inducers. Results: F. tsiangii extracts could protect endothelial cells from H2O2-induced oxidative damages, lower the concentrations of oxidative products and also moderately inhibit platelet aggregation. Conclusion: F. tsiangii extracts might have the effects of protecting endothelial cells from oxidative injuries induced by H2O2, and have anti-oxidant and anti-platelet aggregation activities in vitro. [ABSTRACT FROM AUTHOR]

Patients in ICU were often administered with many kinds of drugs simultaneously. The drug-drug interactions can either affect therapeutic efficacy or increase toxicity of the drugs. Pharmaceutical care based on drug interaction filter application can efficiently screen out potential drug interaction, thus enabling clinical pharmacists to intervene in a faster and more effective manner and at the same time increasing clinical medication safety [ABSTRACT FROM AUTHOR]