1. Correlation of antioxidative properties and vaso-relaxation effects of major active constituents of traditional Chinese medicines
- Author
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Meng Zhang, Shilin Chen, Shun Wan Chan, Yiu Wa Kwan, and Sai Wang Seto
- Subjects
Pharmacology ,biology ,Traditional medicine ,Uncaria rhynchophylla ,business.industry ,Salidroside ,Pharmaceutical Science ,General Medicine ,biology.organism_classification ,Stephania tetrandra ,Tetrandrine ,chemistry.chemical_compound ,Rhynchophylline ,Complementary and alternative medicine ,chemistry ,Drug Discovery ,Molecular Medicine ,Scutellaria baicalensis ,Medicine ,Panax notoginseng ,business ,Baicalin - Abstract
Scutellaria baicalensis Georgi (Labiatae) (“huang qin”), Ligusticum chuanxiong Hort. (Umbelliferae) (“chuang xiong”), Panax notoginseng (Burk.) F.H. Chen (Araliaceae) (“san qi”), Uncaria rhynchophylla (Miq.) Jackson. (Rubiaceae) (“gou teng”), Rhokiola rosea L. (Crassulaceae) (“hong jing tian”) and Stephania tetrandra S. Moore (Menispermaceae) (“fang ji”) are commonly used traditional Chinese medicine (TCM) for hypertensive patients. The pharmacologically active compounds found in these TCMs are baicalin, ligustrazine, notoginsenoside R1, rhynchophylline, salidroside and tetrandrine, respectively, which possess antihypertensive properties with diverse cellular mechanisms. In this study, we attempted to evaluate a possible correlation of the antioxidative activities (using the DPPH assay) and the vaso-relaxation effects (using rat isolated thoracic aorta) of these compounds. In the antioxidative study, a relative order of free radical scavenging capacity (SR%) of baicalin ≥ tetradrine >> salidroside ≥ ligus...
- Published
- 2009