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Start Over Author "Fudong Guo" Journal pharmaceutical development and technology
1 results on '"Fudong Guo"'

1. Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route

Author

Hezhong Ouyang, Jinquan Hu, XingYing Qiu, Shaochang Wu, Fudong Guo, and Youguo Tan

Subjects
Lipopolysaccharides, Biological Products, Drug Carriers, NF-kappa B, Pharmaceutical Science, General Medicine, Mice, Lanosterol, Suspensions, Cyclooxygenase 2, Olanzapine, Delayed-Action Preparations, Liposomes, Animals, Nanoparticles, Particle Size, Antipsychotic Agents
Abstract

This study aims to develop, characterize, and examine olanzapine-loaded solid lipid nanocarriers (OLAN-SLNs) for effective brain delivery. OLAN has poor water solubility and low penetration through blood-brain barrier (BBB). Herein, OLAN-SLNs were fabricated using high-pressure homogenization (HPH) method followed by their investigation for particle properties. Moreover

Published
2022

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