1. The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives
- Author
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Francois Pognan, José M. Fernández, Ferran Sanz, Philip Drew, Alfonso Valencia, Johan van der Lei, Josep Saüch-Pitarch, Carlos Díaz, Juan Manuel Ramírez-Anguita, Giulia Callegaro, Manuel Pastor, Francesco Ronzano, Laura I. Furlong, Salvador Capella-Gutierrez, Emilio Centeno, Niklas Blomberg, Bob van de Water, Erik M. van Mulligen, Janet Piñero, Emre Guney, Philip Rowell, Javier Corvi, Thomas Steger-Hartmann, Jan A. Kors, Frank Bringezu, Katharine Briggs, William C Drewe, Miguel Angel Mayer, Barcelona Supercomputing Center, and Medical Informatics
- Subjects
read across ,drug safety ,Knowledge management ,Legacy data ,Computer science ,Informàtica::Sistemes d'informació [Àrees temàtiques de la UPC] ,data sharing ,lcsh:Medicine ,lcsh:RS1-441 ,Pharmaceutical Science ,Drug safety ,Integrative knowledge management ,Read across ,Toxicology ,Article ,lcsh:Pharmacy and materia medica ,03 medical and health sciences ,0302 clinical medicine ,Data query ,Drug Discovery ,Data mining ,030304 developmental biology ,0303 health sciences ,Computational model ,integrative knowledge management ,translational safety assessment ,Translational safety assessment ,business.industry ,lcsh:R ,Predictive modelling ,data mining ,3. Good health ,Visualization ,Data sharing ,Molecular Medicine ,Mineria de dades ,Modeling and simulation in science, engineering & technology ,predictive modelling ,business ,030217 neurology & neurosurgery ,toxicology - Abstract
eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events. This research received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreements eTRANSAFE (777365). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA companies in kind contribution. The Research Programme on Biomedical Informatics (GRIB) of IMIM and DCEXS-UPF is a member of the Spanish National Bioinformatics Institute (INB), PRB2-ISCIII and is supported by grant PT13/0001/0023, of the PE I + D + i 2013–2016, funded by ISCIII and FEDER. The GRIB also receive support from Agència de Gestió D’ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR, ref.: 2017SGR01020). The DCEXS is a “Unidad de Excelencia María de Maeztu”, funded by the MINECO (ref: MDM-2014-0370).
- Published
- 2021
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