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Your search keyword '"Kubota, Kiyoshi"' showing total 25 results
Start Over Author "Kubota, Kiyoshi" Journal pharmacoepidemiology and drug safety
25 results on '"Kubota, Kiyoshi"'

6. Multi-country rapid adverse drug event assessment: the Asian Pharmacoepidemiology Network (AsPEN) antipsychotic and acute hyperglycaemia study

Author

Pratt, Nicole, Andersen, Morten, Bergman, Ulf, Choi, Nam-Kyong, Gerhard, Tobias, Huang, Cecilia, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Ooba, Nobuhiro, Ösby, Urban, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Sundström, Anders, Yang, Yea-Huei Kao, and Roughead, Elizabeth E

Published
2013
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7. The Asian Pharmacoepidemiology Network (AsPEN): promoting multi-national collaboration for pharmacoepidemiologic research in Asia

Author

Andersen, Morten, Bergman, Ulf, Choi, Nam-Kyong, Gerhard, Tobias, Huang, Cecilia, Jalbert, Jessica, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Ooba, Nobuhiro, Park, Byung-Joo, Pratt, Nicole, Roughead, Elizabeth E., Sato, Tsugumichi, Setoguchi, Soko, Shin, Ju-Young, Sundström, Anders, and Yang, Yea-Huei Kao

Published
2013
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25. Prescription sequence symmetry analysis: assessing risk, temporality, and consistency for adverse drug reactions across datasets in five countries

Author

Ju-Young Shin, Kiyoshi Kubota, Byung Joo Park, Michio Kimura, Kenneth K.C. Man, Esther W. Chan, Nobuhiro Ooba, Edward Chia Cheng Lai, Yea Huei Kao Yang, Elizabeth E. Roughead, Nam Kyong Choi, Tomomi Kimura, Tsugumichi Sato, Nicole L. Pratt, Ian C. K. Wong, Pratt, Nicole, Chan, Esther W, Choi, Nam-Kyong, Kimura, Michio, Kimura, Tomomi, Kubota, Kiyoshi, Lai, Edward Chia-Cheng, Man, Kenneth KC, Ooba, Nobuhiro, Park, Byung-Joo, Sato, Tsugumichi, Shin, Ju-Young, Wong, Ian CK, Kao, Yang Yea-Huei, and Roughead, Elizabeth E

Subjects
medicine.medical_specialty, Asia, Time Factors, pharmacoepidemiology, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Gout, Epidemiology, Amiodarone, Drug Prescriptions, Risk Assessment, prescription symmetry analysis, Pharmacovigilance, Hypothyroidism, Risk Factors, Internal medicine, Original Reports, Odds Ratio, medicine, Adverse Drug Reaction Reporting Systems, Humans, hyperthyroidism, Pharmacology (medical), Medical prescription, Adverse effect, amiodarone, Analysis of Variance, Chi-Square Distribution, business.industry, Australia, Reproducibility of Results, Odds ratio, Pharmacoepidemiology, Confidence interval, Surgery, Thyroxine, pharmacovigilance, Risk assessment, business, Chi-squared distribution
Abstract

Background Prescription sequence symmetry analysis (PSSA) is a signal detection method for adverse drug events. Its capacity to consistently detect adverse drug events across different settings has not been tested. We aimed to determine the consistency of PSSA results for detecting positive and negative control adverse drug events across different settings. Methods Using a distributed network model, we analyzed prescription dispensing data using PSSA in Australia, Hong Kong, Japan, Korea, and Taiwan. Positive control was amiodarone and thyroxine, as a marker of amiodarone-induced hypothyroidism, a known adverse event with a clear temporal relationship to amiodarone initiation. Negative controls were amiodarone and allopurinol, as a marker of amiodarone-induced gout and thyroxine and allopurinol, as a marker of thyroxine-induced gout. Gout is not recorded as an adverse event in product information for either medicine. Adjusted sequence ratios (ASR) were calculated for each country. Pooled estimates were obtained by using the generic inverse variance method. Results A positive association was identified between amiodarone and thyroxine in all settings with a pooled ASR 2.63 (95% confidence interval (CI) 1.47–4.72). Temporal analysis showed the effect occurred within the first few weeks of treatment. No significant associations were found for the negative controls in any setting; pooled ASR were 0.76 (95%CI 0.62–0.93) and 0.98 (95%CI 0.85–1.12) for amiodaroneallopurinol and thyroxine-allopurinol, respectively. Conclusion Despite different health settings, different populations, and different patterns of medicine utilization, PSSA gave consistent estimates across countries for a well-known positive association and two negative control adverse events. © 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd. key words—prescription symmetry analysis; pharmacovigilance; amiodarone; hyperthyroidism; pharmacoepidemiology

Published
2015

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