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Start Over Author "Saito, Yoshiro" Journal pharmacogenetics and genomics
8 results on '"Saito, Yoshiro"'

3. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

Author

Minami, Hironobu, primary, Sai, Kimie, additional, Saeki, Mayumi, additional, Saito, Yoshiro, additional, Ozawa, Shogo, additional, Suzuki, Kazuhiro, additional, Kaniwa, Nahoko, additional, Sawada, Jun-ichi, additional, Hamaguchi, Tetsuya, additional, Yamamoto, Noboru, additional, Shirao, Kuniaki, additional, Yamada, Yasuhide, additional, Ohmatsu, Hironobu, additional, Kubota, Kaoru, additional, Yoshida, Teruhiko, additional, Ohtsu, Atsushi, additional, and Saijo, Nagahiro, additional

Published
2007
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4. CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population

Author

Saito, Yoshiro, primary, Katori, Noriko, additional, Soyama, Akiko, additional, Nakajima, Yukiko, additional, Yoshitani, Takashi, additional, Kim, Su-Ryang, additional, Fukushima-Uesaka, Hiromi, additional, Kurose, Kouichi, additional, Kaniwa, Nahoko, additional, Ozawa, Shogo, additional, Kamatani, Naoyuki, additional, Komamura, Kazuo, additional, Kamakura, Shiro, additional, Kitakaze, Masafumi, additional, Tomoike, Hitonobu, additional, Sugai, Kenji, additional, Minami, Narihiro, additional, Kimura, Hideo, additional, Goto, Yu-ichi, additional, Minami, Hironobu, additional, Yoshida, Teruhiko, additional, Kunitoh, Hideo, additional, Ohe, Yuichiro, additional, Yamamoto, Noboru, additional, Tamura, Tomohide, additional, Saijo, Nagahiro, additional, and Sawada, Jun-ichi, additional

Published
2007
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5. Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese

Author

Maekawa, Keiko, primary, Fukushima-Uesaka, Hiromi, additional, Tohkin, Masahiro, additional, Hasegawa, Ryuichi, additional, Kajio, Hiroshi, additional, Kuzuya, Nobuaki, additional, Yasuda, Kazuki, additional, Kawamoto, Manabu, additional, Kamatani, Naoyuki, additional, Suzuki, Kazuko, additional, Yanagawa, Tatsuo, additional, Saito, Yoshiro, additional, and Sawada, Jun-ichi, additional

Published
2006
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6. Irinotecan pharmacokineticspharmacodynamics and UGT1Agenetic polymorphisms in Japanese roles of UGT1A16and 28

Author

Minami, Hironobu, Sai, Kimie, Saeki, Mayumi, Saito, Yoshiro, Ozawa, Shogo, Suzuki, Kazuhiro, Kaniwa, Nahoko, Sawada, Jun-ichi, Hamaguchi, Tetsuya, Yamamoto, Noboru, Shirao, Kuniaki, Yamada, Yasuhide, Ohmatsu, Hironobu, Kubota, Kaoru, Yoshida, Teruhiko, Ohtsu, Atsushi, and Saijo, Nagahiro

Abstract

SN-38, an active metabolite of irinotecan, is detoxified by glucuronidation with UGT1A isoforms, 1A1, 1A7, 1A9, and 1A10. The pharmacogenetic information on UGT1Ahaplotypes covering all these isoforms is important for the individualized therapy of irinotecan. Associations between UGT1Ahaplotypes and pharmacokineticspharmacodynamics of irinotecan were investigated to identify pharmacogenetic markers.

Published
2007
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7. CYP2C8haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population

Author

Saito, Yoshiro, Katori, Noriko, Soyama, Akiko, Nakajima, Yukiko, Yoshitani, Takashi, Kim, Su-Ryang, Fukushima-Uesaka, Hiromi, Kurose, Kouichi, Kaniwa, Nahoko, Ozawa, Shogo, Kamatani, Naoyuki, Komamura, Kazuo, Kamakura, Shiro, Kitakaze, Masafumi, Tomoike, Hitonobu, Sugai, Kenji, Minami, Narihiro, Kimura, Hideo, Goto, Yu-ichi, Minami, Hironobu, Yoshida, Teruhiko, Kunitoh, Hideo, Ohe, Yuichiro, Yamamoto, Noboru, Tamura, Tomohide, Saijo, Nagahiro, and Sawada, Jun-ichi

Abstract

CYP2C8 is known to metabolize various drugs including an anticancer drug paclitaxel. Although large interindividual differences in CYP2C8 enzymatic activity and several nonsynonymous variations were reported, neither haplotype structures nor their associations with pharmacokinetic parameters of paclitaxel were reported.

Published
2007
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8. Four novel defective alleles and comprehensive haplotype analysis of CYP2C9in Japanese

Author

Maekawa, Keiko, Fukushima-Uesaka, Hiromi, Tohkin, Masahiro, Hasegawa, Ryuichi, Kajio, Hiroshi, Kuzuya, Nobuaki, Yasuda, Kazuki, Kawamoto, Manabu, Kamatani, Naoyuki, Suzuki, Kazuko, Yanagawa, Tatsuo, Saito, Yoshiro, and Sawada, Jun-ichi

Abstract

Genetic variations in cytochrome P450 2C9 (CYP2C9) are known to contribute to interindividual and interethnic variability in response to clinical drugs such as warfarin. In the present study, CYP2C9from 263 Japanese subjects was resequenced, resulting in the discovery of 62 variations including 32 novel ones. In addition to the two known non-synonymous single nucleotide polymorphisms (SNPs), Ile359Leu (3; allele frequency0.030) and Leu90Pro (13; 0.002), seven novel non-synonymous SNPs, Leu17Ile (0.002), Lys118ArgfsX9 (25; 0.002), Thr130Arg (26; 0.002), Arg150Leu (27; 0.004), Gln214Leu (28; 0.002), Pro279Thr (29; 0.002) and Ala477Thr (30; 0.002), were found. Functional characterization of novel alleles using a mammalian cell expression system in vitrorevealed that 25was a null allele and that 26, 28and 30were defective alleles. The 26product showed a 90 decrease in the Vmaxvalue but little change in the Kmvalue towards diclofenac. Both 28and 30products showed two-fold higher Kmvalues and three-fold lower Vmaxvalues than the 1allele, suggesting the importance of Gln214 and Ala477 for substrate recognition. Linkage disequilibrium and haplotype analyses were performed using the detected variations. Only five haplotypes (frequency >0.02) accounted for most (>87) of the inferred haplotypes, and they were closely associated with the haplotypes of CYP2C19in Japanese. Although the haplotype structure of CYP2C9was rather simple in Japanese, the haplotype distribution was quite different from those previously reported in Caucasians and Africans. Taken together, novel defective alleles and detailed haplotype structures would be useful for determining metabolic phenotypes of CYP2C9 substrate drugs in Japanese and probably Asians.

Published
2006
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