1. Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population.
- Author
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Tong HY, Borobia AM, Martínez Ávila JC, Lubomirov R, Muñoz M, Blanco Bañares MJ, Hernández R, Fernández Capitán C, Ramírez E, Frías J, and Carcas AJ
- Subjects
- Aged, Cross-Sectional Studies, Dose-Response Relationship, Drug, Female, Genotype, Humans, Male, Pharmacogenetics methods, White People genetics, Acenocoumarol administration & dosage, Anticoagulants administration & dosage, Cytochrome P-450 Enzyme System genetics, Polymorphism, Genetic genetics
- Abstract
Aim: To evaluate the influence of two variants of P450 oxidoreductase (POR), rs2868177 and POR*28, on the stable dosage of acenocoumarol., Patients & Methods: For this observational, cross-sectional study, patients were undergone stable anticoagulant treatment with acenocoumarol. Univariate and multiple regression analyses were performed to assess the influence of POR polymorphisms., Results: About 340 patients were enrolled. Multiple regression had a coefficient of determination (R
2 ) of 51.5% and an Akaike information criterion of 234.22. The inclusion of POR*28 polymorphisms increased the R2 to 52.0% and reduced the Akaike information criteria to 230.58. The POR*28 heterozygote showed statistical significance in the algorithm., Conclusion: The POR*28 heterozygote appears to be associated with the stable dose of acenocoumarol, but its clinical contribution to the prediction of the dosing of this drug is minimal.- Published
- 2017
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