1. Genetic factors associated with tuberculosis-related clinical outcomes in HIV-infected Black African patients: a systematic review and meta-analysis
- Author
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Daniel Kiiza, Innocent G Asiimwe, Stephen Walimbwa, and Christine Wiltshire Sekaggya
- Subjects
medicine.medical_specialty ,Tuberculosis ,Black african ,Genotype ,Anti-HIV Agents ,Antitubercular Agents ,Black People ,HIV Infections ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,Hiv infected ,Genetics ,medicine ,Humans ,Lung function ,Africa South of the Sahara ,Pharmacology ,business.industry ,Coinfection ,medicine.disease ,Peripheral neuropathy ,Treatment Outcome ,Meta-analysis ,Molecular Medicine ,business - Abstract
Aim: To evaluate the genetic factors influencing tuberculosis (TB) clinical outcomes in HIV-infected Black African patients. Materials & methods: We systematically searched and identified eligible publications from >550 databases indexed through February 2021. Results: Eighteen studies were included in the qualitative synthesis. Only two cohorts from one study were included in quantitative synthesis of which the low expression MIF−794 CATT5,6 ( 5/5 + 5/6 + 6/6) genotypes were not associated with TB infectivity in HIV-infected patients (OR: 1.31, 95% CI: 0.46–3.79). Other TB clinical outcomes observed in HIV/TB co-infected patients included: drug-induced liver injury, peripheral neuropathy, mortality, lung function and TB cure. Conclusion: This review finds inconclusive evidence that genetic factors are associated with TB clinical outcomes among HIV-infected patients in sub-Saharan Africa.
- Published
- 2021