1. Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest
- Author
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Schneider, Suzanne M, Lee, Stuart MC, Feiveson, Alan H, Watenpaugh, Donald E, Macias, Brandon R, and Hargens, Alan R
- Subjects
Medical Physiology ,Biomedical and Clinical Sciences ,Physical Activity ,Prevention ,Women's Health ,Clinical Research ,Musculoskeletal ,Adult ,Bed Rest ,Exercise Test ,Exercise Therapy ,Female ,Humans ,Isometric Contraction ,Leg ,Lower Body Negative Pressure ,Male ,Muscle Strength ,Physical Endurance ,Space Flight ,Young Adult ,Body composition ,head down tilt ,isokinetic ,microgravity ,muscle atrophy ,spaceflight ,Physiology ,Clinical Sciences ,Medical physiology - Abstract
Leg muscle mass and strength are decreased during reduced activity and non-weight-bearing conditions such as bed rest (BR) and spaceflight. Supine treadmill exercise within lower body negative pressure (LBNPEX) provides full-body weight loading during BR and may prevent muscle deconditioning. We hypothesized that a 40-min interval exercise protocol performed against LBNPEX 6 days week(-1) would attenuate losses in leg lean mass (LLM), strength, and endurance during 6° head-down tilt BR, with similar benefits for men and women. Fifteen pairs of healthy monozygous twins (8 male and 7 female pairs) completed 30 days of BR with one sibling of each twin pair assigned randomly as the non-exercise control (CON) and the other twin as the exercise subject (EX). Before and after BR, LLM and isokinetic leg strength and endurance were measured. Mean knee and ankle extensor and flexor strength and endurance and LLM decreased from pre- to post-BR in the male CON subjects (P
- Published
- 2016