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Start Over Author "Bennett, Richard N." Journal phytochemistry
5 results on '"Bennett, Richard N."'

5. Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert).

Author

Svehliková V, Bennett RN, Mellon FA, Needs PW, Piacente S, Kroon PA, and Bao Y

Subjects
Acetylation, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents pharmacology, Apigenin chemistry, Apigenin pharmacology, Biodegradation, Environmental, Chromatography, High Pressure Liquid, Drug Stability, Gas Chromatography-Mass Spectrometry, Glucosides chemistry, Glucosides pharmacology, Hydrogen-Ion Concentration, Isomerism, Magnetic Resonance Spectroscopy, Solvents, Temperature, Anti-Inflammatory Agents isolation & purification, Apigenin isolation & purification, Glucosides isolation & purification, Matricaria chemistry
Abstract

The major flavonoids in the white florets of chamomile (Chamomilla recutita [L.] Rauschert) were rapidly purified using a combination of polyamide solid-phase extraction and preparative HPLC. From the combined LC/MS, LC/MS/MS, and NMR data the apigenin glucosides were identified as apigenin 7-O-glucoside (Ap-7-Glc), Ap-7-(6"-malonyl-Glc), Ap-7-(6"-acetyl-Glc), Ap-7-(6"-caffeoyl-Glc), Ap-7-(4"-acetyl-Glc), Ap-7-(4"-acetyl,6"-malonyl-Glc), and a partially characterised apigenin-7-(mono-acetyl/mono-malonylglucoside) isomer. Malonyl and caffeoyl derivatives of Ap-7-Glc have not previously been identified in chamomile. The two mono-acetyl/mono-malonyl flavonoids have not previously been reported in any plant species. These acylated glucosides are unstable and degrade to form acetylated compounds or Ap-7-Glc. The degradation products formed are dependent on the extraction and storage conditions, i.e. temperature, pH and solvent.

Published
2004
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