1. 4′-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species
- Author
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Edwin Kamau, Matthias Heydenreich, Solomon Derese, Leonard Barasa, Abiy Yenesew, Amir O. Yusuf, and Hoseah M. Akala
- Subjects
chemistry.chemical_classification ,Millettia leucantha ,Traditional medicine ,biology ,Chemistry ,Tephrosin ,Plant Science ,Isoflavones ,biology.organism_classification ,Biochemistry ,Rotenoid ,Millettia ,chemistry.chemical_compound ,Triterpene ,Institut für Chemie ,Chrysin ,Agronomy and Crop Science ,Biotechnology ,Lupeol - Abstract
The CH 2 Cl 2 /MeOH (1:1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC 50 = 10–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum . Chromatographic separation of the extract led to the isolation of a new isoflavone, 4′-prenyloxyderrone ( 1 ), together with known isoflavones (8- O -methylretusin, durmillone, maximaisoflavone B, maximaisoflavone H and maximaisoflavone J), a rotenoid (tephrosin) and a triterpene (lupeol). Similar investigation of Millettia leucantha resulted in the identification of the isoflavones afrormosin and wistin, and the flavone chrysin. The identification of these compounds was based on their spectroscopic data. Five of the isoflavones isolated from these plants as well as 11 previously reported compounds from Millettia dura were tested and showed good to moderate antiplasmodial activities (IC 50 = 13–53 μM), with the new compound, 4′-prenyloxyderrone, being the most active (IC 50 = 13–15 μM).
- Published
- 2014
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