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Start Over Author "Saiag, Philippe" Journal pigment cell & melanoma research
6 results on '"Saiag, Philippe"'

2. Genetic variation at KIT locus may predispose to melanoma

Author

Bourillon, Agnes, Hu, Hui-Han, Hetet, Gilles, Lacapere, Jean-Jacques, André, Jocelyne, Descamps, Vincent, Basset-Seguin, Nicole, Ogbah, Zighereda, Puig, Susana, Saiag, Philippe, Bagot, Martine, Bensussan, Armand, Grandchamp, Bernard, Dumaz, Nicolas, and Soufir, Nadem

Published
2013
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3. Inherited variants in the MC1R gene and survival from cutaneous melanoma: a BioGenoMEL study

Author

Davies, John R., Randerson-Moor, Juliette, Kukalizch, Kairen, Harland, Mark, Kumar, Rajiv, Madhusudan, Srinivasan, Nagore, Eduardo, Hansson, Johan, Höiom, Veronica, Ghiorzo, Paola, Gruis, Nelleke A., Kanetsky, Peter A., Wendt, Judith, Pjanova, Dace, Puig, Susana, Saiag, Philippe, Schadendorf, Dirk, Soufir, Nadem, Okamoto, Ichiro, Affleck, Paul, García-Casado, Zaida, Ogbah, Zighereda, Ozola, Aija, Queirolo, Paola, Sucker, Antje, Barrett, Jennifer H., van Doorn, Remco, Bishop, Timothy D., and Newton-Bishop, Julia

Published
2012
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5. Hyponatremia and MAP‐kinase inhibitors in malignant melanoma: Frequency, pathophysiological aspects and clinical consequences.

Author

Assan, Florence, Vilaine, Eve, Wagner, Sandra, Longvert, Christine, Saiag, Philippe, Seidowsky, Alexandre, Bourgault‐Villada, Isabelle, and Massy, Ziad A.

Subjects
HYPONATREMIA, MELANOMA treatment, PATHOLOGICAL physiology, BRAF genes, NEPHROTOXICOLOGY
Abstract

The incidence of malignant melanoma has increased over the past two decades. A combined BRAF/MEK inhibitor regimen has been shown to lead to prolonged survival and progression‐free survival in patients with metastatic BRAF V600‐mutant melanoma. Different nephrotoxic effects have been described, among them hyponatremia. The goal of the present narrative review was to understand the pathophysiological mechanisms driving hyponatremia when using selective BRAF inhibitors and/or MEK inhibitors in order to propose potential strategies to prevent or to treat this side effect. Several mechanisms of kidney injury have been suggested including changes in glomerular and tubular function. However, the precise mechanisms of hyponatremia remain unknown. Our hypothesis is that BRAF/MEK inhibitors lead to hyponatremia and water retention (so‐called dilution hyponatremia) by activating aquaporin 2 (AQP2) trafficking from its intracellular compartment to the luminal cell membrane, and by activating ENaC channel. Therefore, we recommend treating the hyponatremia related to BRAF/MEK inhibitors with restriction of fluid intake. [ABSTRACT FROM AUTHOR]

Published
2019
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6. Genetic variation atKITlocus may predispose to melanoma

Author

Bourillon, Agnes, primary, Hu, Hui‐Han, additional, Hetet, Gilles, additional, Lacapere, Jean‐Jacques, additional, André, Jocelyne, additional, Descamps, Vincent, additional, Basset‐Seguin, Nicole, additional, Ogbah, Zighereda, additional, Puig, Susana, additional, Saiag, Philippe, additional, Bagot, Martine, additional, Bensussan, Armand, additional, Grandchamp, Bernard, additional, Dumaz, Nicolas, additional, and Soufir, Nadem, additional

Published
2012
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