Search

Your search keyword '"Tanemura, Atsushi"' showing total 11 results
Start Over Author "Tanemura, Atsushi" Journal pigment cell & melanoma research
11 results on '"Tanemura, Atsushi"'

1. Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas

Author

Nojima, Kohei, primary, Hayashi, Masahiro, additional, Tanemura, Atsushi, additional, Al‐Busani, Hind, additional, Saito, Toru, additional, Suzuki, Tamio, additional, Ishikawa, Masashi, additional, Mori, Taisuke, additional, Wada, Shogo, additional, Yamazaki, Naoya, additional, Katayama, Ichiro, additional, Mori, Hiroki, additional, Yokozeki, Hiroo, additional, Okiyama, Naoko, additional, Sasaki, Yoshiyuki, additional, and Namiki, Takeshi, additional

Published
2023
Full Text
View/download PDF

2. Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas.

Author

Nojima, Kohei, Hayashi, Masahiro, Tanemura, Atsushi, Al‐Busani, Hind, Saito, Toru, Suzuki, Tamio, Ishikawa, Masashi, Mori, Taisuke, Wada, Shogo, Yamazaki, Naoya, Katayama, Ichiro, Mori, Hiroki, Yokozeki, Hiroo, Okiyama, Naoko, Sasaki, Yoshiyuki, and Namiki, Takeshi

Subjects
PROGNOSIS, MELANOMA, DISEASE relapse, PROGRESSION-free survival, BRAF genes, OVERALL survival, PROGNOSTIC tests
Abstract

A PTEN deficiency leads to the activation of phospho‐Akt at serine 473 (p‐Akt) and promotes the tumorigenesis of melanomas by coupling with NUAK2 amplification. We tested the prognostic impact of p‐Akt and/or NUAK2 expression on the relapse‐free survival (RFS) and overall survival (OS) of melanoma patients. Primary tumors from patients with acral melanomas (112), Low‐cumulative sun damage (CSD) melanomas (38), and High‐CSD melanomas (18) were examined using immunohistochemistry and their prognostic significance was analyzed statistically. The expression of p‐Akt was found in 32.1%, 68.4%, and 55.6% of acral, Low‐CSD, and High‐CSD melanomas, while NUAK2 expression was found in 46.4%, 76.3%, and 50.0%, respectively. Either p‐Akt or NUAK2 expression was inversely correlated with the RFS of primary melanoma patients and acral melanoma patients (p‐Akt: p <.0001, p <.0001; NUAK2; p =.0005, p <.0001, respectively). Strikingly, multivariate analyses revealed that p‐Akt had a significant impact on RFS (Hazard ratio = 4.454; p <.0001), while NUAK2 did not. Further subset analyses revealed that p‐Akt expression had an inferior RFS of patients with acral melanomas (Hazard ratio = 4.036; p =.0005). We conclude that the expression of p‐Akt has a significant impact on RFS of patients with primary melanomas and can predict the relapse of patients with acral melanomas. Research Highlights: The expression of p‐Akt has a significant impact on relapse‐free survival in primary melanoma patients and can predict the relapse of acral melanoma patients. The expression of p‐Akt can be a promising biomarker to stratify acral melanomas for clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

7. Genome‐wide association study identifies CDH13 as a susceptibility gene for rhododendrol‐induced leukoderma

Author

Okamura, Ken, primary, Abe, Yuko, additional, Naka, Izumi, additional, Ohashi, Jun, additional, Yagami, Akiko, additional, Matsunaga, Kayoko, additional, Kobayashi, Yui, additional, Fukai, Kazuyoshi, additional, Tanemura, Atsushi, additional, Katayama, Ichiro, additional, Masui, Yukiko, additional, Ito, Akiko, additional, Yamashita, Toshiharu, additional, Nagai, Hiroshi, additional, Nishigori, Chikako, additional, Oiso, Naoki, additional, Aoyama, Yumi, additional, Araki, Yuta, additional, Saito, Toru, additional, Hayashi, Masahiro, additional, Hozumi, Yutaka, additional, and Suzuki, Tamio, additional

Published
2020
Full Text
View/download PDF

10. Major association of vitiligo withHLA-A*02:01in Japanese

Author

Jin, Ying, primary, Hayashi, Masahiro, additional, Fain, Pamela R., additional, Suzuki, Tamio, additional, Fukai, Kazuyoshi, additional, Oiso, Naoki, additional, Tanemura, Atsushi, additional, Holcomb, Cherie L., additional, Rastrou, Melinda, additional, Erlich, Henry A., additional, and Spritz, Richard A., additional

Published
2015
Full Text
View/download PDF

11. High molecular weight-melanoma-associated antigen as a biomarker of desmoplastic melanoma

Author

Goto, Yasufumi, primary, Arigami, Takaaki, additional, Murali, Rajmohan, additional, Scolyer, Richard A., additional, Tanemura, Atsushi, additional, Takata, Minoru, additional, Turner, Roderick R., additional, Nguyen, Linhda, additional, Nguyen, Tung, additional, Morton, Donald L., additional, Ferone, Soldano, additional, and Hoon, Dave S.B., additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results