1. Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species
- Author
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Anthony Booker, Chen Huang, Linru Mou, Caroline S. Weckerle, Francesca Scotti, Caroline Maake, and Michael Heinrich
- Subjects
China ,Open wounds ,Pharmaceutical Science ,traditional medicine ,computer.software_genre ,wound treatment ,Analytical Chemistry ,Unmet needs ,Drug Discovery ,Data Mining ,Medicine ,Chinese pharmacopoeia ,Medicinal plants ,Wound treatment ,Pharmacology ,Plants, Medicinal ,business.industry ,Organic Chemistry ,food and beverages ,Original Papers ,herbal medicines ,photodynamic therapy ,Complementary and alternative medicine ,Plant species ,Molecular Medicine ,Chinese pharmacopeia ,Medicine, Traditional ,Plant Preparations ,Biological and Pharmacological Activity ,Data mining ,business ,computer - Abstract
Efficient wound treatment that addresses associated infections and inflammation remains one of the big unmet needs, especially in low- and middle-income countries. One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight. Data mining strategies using existing resources offer an excellent basis for developing such an approach with many potential plant candidates. In the present analysis, we researched the 535 botanical drugs included in the Chinese pharmacopeia and identified 183 medicinal plant species, 82 for treating open wounds caused by trauma and 101 for inflammatory skin conditions. After further screening for reports on the presence of known photoactive compounds, we determined a core group of 10 scientifically lesser-known botanical species that may potentially be developed into more widely used topical preparations for photodynamic treatment of infected wounds. Our predictive approach may contribute to developing a more evidence-based use of herbal medicines.
- Published
- 2021