1. Polyoxypregnane Glycosides from the Roots of Marsdenia tenacissima and Their Anti-HIV Activities
- Author
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Xu Pang, He-Shui Yu, Li-Yan Yu, Li-Ping Kang, Li-Xia Zhang, Lifeng Han, Hai-Tao Li, Bai-Ping Ma, Bao-Lin Guo, Xiao Mei Fang, and Yang Zhao
- Subjects
Anti-HIV Agents ,Marsdenia ,Pharmaceutical Science ,Marsdenia tenacissima ,HIV Infections ,01 natural sciences ,Plant Roots ,Analytical Chemistry ,Chinese traditional ,Drug Discovery ,Botany ,Medicine, Chinese Traditional ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,biology ,Plant roots ,Molecular Structure ,Plant Stems ,010405 organic chemistry ,Anti hiv ,Organic Chemistry ,Glycoside ,Saponins ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,Phytochemical ,chemistry ,HIV-1 ,Molecular Medicine ,Polyoxypregnane glycoside ,Drugs, Chinese Herbal - Abstract
A continuous phytochemical study on the roots of Marsdenia tenacissima led to the isolation and identification of 13 new polyoxypregnane glycosides named marstenacissides B10-B17 (1, 2, 4, 7, 8, 11, 12, and 14) and marstenacissides A8-A12 (3, 9, 10, 13, and 15) in addition to two known polyoxypregnane glycosides marsdenosides M and L (5 and 6). Their structures were established by spectroscopic techniques and by comparison with the reported data in the literature. Moreover, the anti-HIV activities of these isolates and the previous isolated marstenacissides A1-A7 and B1-B9 were assessed, some of which exhibited slight or negligible effects against HIV-1.
- Published
- 2016