1. Carboline Alkaloids from Psammosilene tunicoides and Their Cytotoxic Activities.
- Author
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Junmian Tian, Yunheng Shen, Huiliang Li, Runhui Liu, Lei Shan, Jinming Gao, and Weidong Zhang
- Subjects
ALKALOIDS ,CELL culture ,DOXORUBICIN ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,PHARMACEUTICAL chemistry ,PLANT roots ,TOXICITY testing ,IN vitro studies - Abstract
Five new carboline alkaloids, tunicoidines A-E (1-5), and two known carboline alkaloids, 1-acetyl-β-carboline-3-carboxylic acid (6) and 1-acetyl-3-carbomethoxyl-β-carboline (7), were isolated for the first time from the root of Psammosilene tunicoides. The structures of the new carboline alkaloidswere established on the basis of 1D- and 2D-NMR, and HR-MS spectroscopic analyses. The seven compounds were evaluated for cytotoxicity against A549, HCT116, ZR-75-30, and HL-60 cell lines. However, only compound 7 had potent cytotoxic activity against the HCT116 cell line with an IC
50 value of 9.67 µg/mL, while the others showed no cytotoxic activities against the four tested cell lines. [ABSTRACT FROM AUTHOR]- Published
- 2012
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