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Your search keyword '"SHOUYU GUO"' showing total 2 results
Start Over Author "SHOUYU GUO" Journal planta medica
2 results on '"SHOUYU GUO"'

1. Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum

Author

Shouyu Guo, Hongwei Liu, Baosong Chen, Ying Huang, Buddha Bahadur Basnet, Yerlan Melsuly Suleimen, Li Bao, and Ke Ma

Subjects
Staphylococcus aureus, Magnetic Resonance Spectroscopy, Stereochemistry, Pharmaceutical Science, Bacillus subtilis, medicine.disease_cause, Sesquiterpene, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Anti-Infective Agents, Cell Line, Tumor, Candida albicans, Drug Discovery, Escherichia coli, medicine, Humans, Pharmacology, chemistry.chemical_classification, Xylariales, biology, Cytotoxins, 010405 organic chemistry, Circular Dichroism, Organic Chemistry, Glycoside, Hep G2 Cells, Antimicrobial, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Molecular Medicine, K562 Cells, Antibacterial activity, Lactone
Abstract

As part of our search for new cytotoxic and antimicrobial natural products from endolichenic fungi, 19 compounds including 1 new 10-member lactone (2), 1 new polyacetylene glycoside (3), 1 new brasilane-type sesquiterpenoid glycoside (4), and 2 isobenzofuran-1(3H)-one derivatives (5 and 6) were isolated from the solid culture of the endolichenic fungus Hypoxylon fuscum. Their structures were unambiguously elucidated by NMR spectroscopic data, MS, ECD (electronic circular dichroism) calculation, and chemical methods. The cytotoxic effects on K562, SW480, and HEPG2 cell lines and the antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Candida albicans were assessed. Compounds 1, 2, and 5 exhibited moderate cytotoxicity against K562, SW480, and HEPG2 cell lines while compounds 1, 9, and 11 displayed weak antibacterial activity against S. aureus.

Published
2019

2. Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

Author

Hongwei Liu, Li Liu, Shouyu Guo, Yerlan Suleimen, Li Bao, Haiyang Yu, Jinwei Ren, Baosong Chen, and Buddha Bahadur Basnet

Subjects
Myrothecium inundatum, Magnetic Resonance Spectroscopy, Lichens, Stereochemistry, Ethyl acetate, Pharmaceutical Science, Antineoplastic Agents, Fungus, Crystallography, X-Ray, 01 natural sciences, Analytical Chemistry, Terpene, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Cytotoxic T cell, Humans, Cytotoxicity, Pharmacology, chemistry.chemical_classification, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Absolute configuration, Glycoside, biology.organism_classification, Triterpenes, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, chemistry, Hypocreales, Molecular Medicine, Drug Screening Assays, Antitumor, K562 Cells
Abstract

Two new arborinane-type triterpenes, myrotheols A (1) and B (2), two new arborinane-type glycosides, myrothesides C (3) and D (4), together with four known diterpenes (5 – 8) were isolated from the ethyl acetate extract of the endolichenic fungus Myrothecium inundatum. The structures of new compounds 1 – 4 were elucidated by NMR and MS analyses. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 3 and 4 represent the first two natural 4-O-methyl-α-D-mannosides. Compounds 1 – 8 exhibited cytotoxicity against K562 and RKO human cancer cell lines.

Published
2019

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