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Start Over Author "Tsamo E" Journal planta medica
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8. Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea.

Author

Lenta BN, Kamdem LM, Ngouela S, Tantangmo F, Devkota KP, Boyom FF, Rosenthal PJ, and Tsamo E

Subjects
Antimalarials chemistry, Antimalarials isolation & purification, Fruit chemistry, Molecular Structure, Plant Extracts chemistry, Xanthones chemistry, Xanthones isolation & purification, Antimalarials pharmacology, Clusiaceae chemistry, Plant Extracts pharmacology, Plasmodium falciparum drug effects, Xanthones pharmacology
Abstract

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (-)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1- 3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC₅₀ values below 3 µM., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2011
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