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2 results on '"autonomic diabetic neuropathy"'

1. Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Author

Kerly Shamyra Silva-Alves, Francisco Walber Ferreira-da-Silva, Andrelina Noronha Coelho-de-Souza, and José Henrique Leal-Cardoso

Subjects
Croton zehntneri, essential oil, autonomic diabetic neuropathy, vagus nerve, compound action potential, Botany, QK1-989
Abstract

Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.

Published
2021
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2. Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

Author

José Henrique Leal-Cardoso, Kerly Shamyra da Silva-Alves, Andrelina Noronha Coelho-de-Souza, and Francisco Walber Ferreira-da-Silva

Subjects
0301 basic medicine, autonomic diabetic neuropathy, Plant Science, Pharmacology, Autonomic diabetic neuropathy, Article, essential oil, law.invention, Croton zehntneri, 03 medical and health sciences, 0302 clinical medicine, law, Diabetes mellitus, vagus nerve, Medicine, Ecology, Evolution, Behavior and Systematics, Essential oil, Ecology, biology, business.industry, Botany, medicine.disease, biology.organism_classification, Croton, compound action potential, Vagus nerve, Compound muscle action potential, 030104 developmental biology, Rheobase, nervous system, QK1-989, business, Complication, 030217 neurology & neurosurgery
Abstract

Autonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of Croton zehntneri (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.

Published
2021

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