1. Physical inactivity and platelet function in humans and brown bears: A comparative study
- Author
-
Ole-Gunnar Støen, Ole Fröbert, Karen G. Welinder, Stéphane Blanc, Alina L. Evans, Karin Arinell, Department of Cardiology and Acute Internal Medicine Faculty of Health Orebro University, Department of Chemistry and Bioscience Aalborg University, Norwegian Institute for Nature Research (NINA), Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences, Department of Cardiology, Örebro University, Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Adult ,Blood Platelets ,Male ,Platelets ,0301 basic medicine ,Hibernation ,medicine.medical_specialty ,Platelet Aggregation ,Platelet aggregation ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Bed rest ,Immobilization ,03 medical and health sciences ,0302 clinical medicine ,Physical Conditioning, Animal ,Internal medicine ,medicine ,Animals ,Humans ,Platelet ,Active state ,Ursus ,Blood Coagulation ,Exercise ,ComputingMilieux_MISCELLANEOUS ,Hematologic Tests ,biology ,business.industry ,Temperature ,Thrombosis ,Hematology ,General Medicine ,Blood flow ,biology.organism_classification ,medicine.disease ,030104 developmental biology ,Endocrinology ,[SDE]Environmental Sciences ,Female ,Seasons ,business ,Biomarkers ,Ursidae - Abstract
Physical inactivity increases the risk of thromboembolism. However, good standardized human models on inactivity are in short supply and experimental models are few. Our objective was to investigate how standardized bed rest affects platelet aggregation in humans and to investigate if aggregation is altered in a translational model system – the hibernating brown bear (Ursus arctos). We collected blood from (1) healthy male volunteers participating in a 21-day bed rest study in head-down tilt position (−6°) 24 h a day; (2) free-ranging brown bears captured during winter hibernation and again during active state in summer. We analyzed platelet function using multiple electrode platelet aggregometry. In total, 9 healthy male volunteers (age 31.0 ± 6.4 years) and 13 brown bears (7 females and 6 males, age 2.8 ± 0.6 years) were included. In hibernating bears adenosine diphosphate, arachidonic acid, thrombin receptor activating peptide, and collagen impedance aggregometry tests were all halved compared to summer active state. In human volunteers no statistically significant changes were found between baseline and the end of bed rest. In human male volunteers 3 weeks of bed rest did not affect platelet function. In hibernating brown bears platelet aggregation was halved compared to summer and we hypothesize that this is a protective measure to avoid formation of thrombi under periods of low blood flow.
- Published
- 2017