Search

Your search keyword '"Bak, Mads"' showing total 5 results
Start Over Author "Bak, Mads" Journal plos genetics
5 results on '"Bak, Mads"'

1. Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Author

Audain, Enrique, primary, Wilsdon, Anna, additional, Breckpot, Jeroen, additional, Izarzugaza, Jose M. G., additional, Fitzgerald, Tomas W., additional, Kahlert, Anne-Karin, additional, Sifrim, Alejandro, additional, Wünnemann, Florian, additional, Perez-Riverol, Yasset, additional, Abdul-Khaliq, Hashim, additional, Bak, Mads, additional, Bassett, Anne S., additional, Benson, D. Woodrow, additional, Berger, Felix, additional, Daehnert, Ingo, additional, Devriendt, Koenraad, additional, Dittrich, Sven, additional, Daubeney, Piers EF, additional, Garg, Vidu, additional, Hackmann, Karl, additional, Hoff, Kirstin, additional, Hofmann, Philipp, additional, Dombrowsky, Gregor, additional, Pickardt, Thomas, additional, Bauer, Ulrike, additional, Keavney, Bernard D., additional, Klaassen, Sabine, additional, Kramer, Hans-Heiner, additional, Marshall, Christian R., additional, Milewicz, Dianna M., additional, Lemaire, Scott, additional, Coselli, Joseph S., additional, Mitchell, Michael E., additional, Tomita-Mitchell, Aoy, additional, Prakash, Siddharth K., additional, Stamm, Karl, additional, Stewart, Alexandre F. R., additional, Silversides, Candice K., additional, Siebert, Reiner, additional, Stiller, Brigitte, additional, Rosenfeld, Jill A., additional, Vater, Inga, additional, Postma, Alex V., additional, Caliebe, Almuth, additional, Brook, J. David, additional, Andelfinger, Gregor, additional, Hurles, Matthew E., additional, Thienpont, Bernard, additional, Larsen, Lars Allan, additional, and Hitz, Marc-Phillip, additional

Published
2021
Full Text
View/download PDF

2. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

Author

Audain, Enrique, primary, Wilsdon, Anna, additional, Breckpot, Jeroen, additional, Izarzugaza, Jose M. G., additional, Fitzgerald, Tomas W., additional, Kahlert, Anne-Karin, additional, Sifrim, Alejandro, additional, Wünnemann, Florian, additional, Perez-Riverol, Yasset, additional, Abdul-Khaliq, Hashim, additional, Bak, Mads, additional, Bassett, Anne S., additional, Benson, Woodrow D., additional, Berger, Felix, additional, Daehnert, Ingo, additional, Devriendt, Koenraad, additional, Dittrich, Sven, additional, Daubeney, Piers EF, additional, Garg, Vidu, additional, Hackmann, Karl, additional, Hoff, Kirstin, additional, Hofmann, Philipp, additional, Dombrowsky, Gregor, additional, Pickardt, Thomas, additional, Bauer, Ulrike, additional, Keavney, Bernard D., additional, Klaassen, Sabine, additional, Kramer, Hans-Heiner, additional, Marshall, Christian R., additional, Milewicz, Dianna M., additional, Lemaire, Scott, additional, Coselli, Joseph S., additional, Mitchell, Michael E., additional, Tomita-Mitchell, Aoy, additional, Prakash, Siddharth K., additional, Stamm, Karl, additional, Stewart, Alexandre F. R., additional, Silversides, Candice K., additional, Siebert, Reiner, additional, Stiller, Brigitte, additional, Rosenfeld, Jill A., additional, Vater, Inga, additional, Postma, Alex V., additional, Caliebe, Almuth, additional, Brook, J. David, additional, Andelfinger, Gregor, additional, Hurles, Matthew E., additional, Thienpont, Bernard, additional, Larsen, Lars Allan, additional, and Hitz, Marc-Phillip, additional

Published
2021
Full Text
View/download PDF

3. Replicative and non-replicative mechanisms in the formation of clustered CNVs are indicated by whole genome characterization

Author

Nazaryan-Petersen, Lusine, primary, Eisfeldt, Jesper, additional, Pettersson, Maria, additional, Lundin, Johanna, additional, Nilsson, Daniel, additional, Wincent, Josephine, additional, Lieden, Agne, additional, Lovmar, Lovisa, additional, Ottosson, Jesper, additional, Gacic, Jelena, additional, Mäkitie, Outi, additional, Nordgren, Ann, additional, Vezzi, Francesco, additional, Wirta, Valtteri, additional, Käller, Max, additional, Hjortshøj, Tina Duelund, additional, Jespersgaard, Cathrine, additional, Houssari, Rayan, additional, Pignata, Laura, additional, Bak, Mads, additional, Tommerup, Niels, additional, Lundberg, Elisabeth Syk, additional, Tümer, Zeynep, additional, and Lindstrand, Anna, additional

Published
2018
Full Text
View/download PDF

5. REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Author

Juri Rappsilber, Shuchi Agrawal-Singh, Mads Bak, Klaus Hansen, Mads Lerdrup, Erik Södersten, Nikolaj Dietrich, Eskild Landt, Niels Tommerup, Lerdrup, Mads [0000-0002-7730-8973], Landt, Eskild [0000-0002-3426-4819], Bak, Mads [0000-0003-2762-1002], Tommerup, Niels [0000-0003-2304-0112], Rappsilber, Juri [0000-0001-5999-1310], Södersten, Erik [0000-0002-2998-4889], Hansen, Klaus [0000-0001-9657-8816], and Apollo - University of Cambridge Repository

Subjects
Cancer Research, Jumonji Domain-Containing Histone Demethylases, Polycomb-Group Proteins, Mice, 0302 clinical medicine, Molecular Cell Biology, Genetics(clinical), Genetics (clinical), Regulation of gene expression, Neurons, 0303 health sciences, Teratoma, Gene Expression Regulation, Developmental, Cell Differentiation, Genomics, CpG site, DNA methylation, Research Article, Protein Binding, lcsh:QH426-470, Repressor, Tretinoin, macromolecular substances, Biology, 03 medical and health sciences, Genetics, Polycomb-group proteins, Animals, Humans, Molecular Biology, Transcription factor, Ecology, Evolution, Behavior and Systematics, Embryonic Stem Cells, 030304 developmental biology, Binding Sites, HEK 293 cells, Molecular biology, Embryonic stem cell, Repressor Proteins, lcsh:Genetics, HEK293 Cells, CpG Islands, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Polycomb Repressive Complex (PRC) 1 and PRC2 regulate genes involved in differentiation and development. However, the mechanism for how PRC1 and PRC2 are recruited to genes in mammalian cells is unclear. Here we present evidence for an interaction between the transcription factor REST, PRC1, and PRC2 and show that RNF2 and REST co-regulate a number of neuronal genes in human teratocarcinoma cells (NT2-D1). Using NT2-D1 cells as a model of neuronal differentiation, we furthermore showed that retinoic-acid stimulation led to displacement of PRC1 at REST binding sites, reduced H3K27Me3, and increased gene expression. Genome-wide analysis of Polycomb binding in Rest−/− and Eed−/− mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently of CpG islands and the H3K27Me3 mark. Surprisingly, PRC2 was frequently increased around Rest binding sites located in CpG-rich regions in the Rest−/− mES cells, indicating a more complex interplay where Rest also can limit PRC2 recruitment. Therefore, we propose that Rest has context-dependent functions for PRC1- and PRC2- recruitment, which allows this transcription factor to act both as a recruiter of Polycomb as well as a limiting factor for PRC2 recruitment at CpG islands., Author Summary Multicellular organisms are composed of a large number of specialized cell types that all originate from the Embryonic Stem cell (ES cell). It is crucial for the maintenance of naïve ES cells that developmental genes are kept in an off-state until appropriate differentiation stimuli are received. Polycomb Repressive Complexes, PRC1 and PRC2, are bound at and repress the activity of a large number of key developmental genes in ES cells and at different stages of differentiation. While in Drosophila the PRC complexes are recruited to DNA elements called Polycomb Response Elements (PREs), through the interaction with transcription factors; examples of such factors remain poorly characterized in mammals. We here demonstrate that the transcription factor Rest interacts with and is required for recruitment of PRC1 and PRC2 to a subset of Rest target genes in mouse embryonic stem (mES) cells. In line with REST being a repressor of neuronal genes, we found that PRC1 and PRC2 co-localized with REST at genes involved in neuronal development and got displaced during neuronal differentiation. Based on our data we propose that the PRC1 and PRC2 complexes function as co-repressors for Rest to control the timed expression of developmental genes in the process of cellular differentiation.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results