10 results on '"Van Doorn, H Rogier"'
Search Results
2. One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia
- Author
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Barkham, Timothy, primary, Zadoks, Ruth N., additional, Azmai, Mohammad Noor Amal, additional, Baker, Stephen, additional, Bich, Vu Thi Ngoc, additional, Chalker, Victoria, additional, Chau, Man Ling, additional, Dance, David, additional, Deepak, Rama Narayana, additional, van Doorn, H. Rogier, additional, Gutierrez, Ramona A., additional, Holmes, Mark A., additional, Huong, Lan Nguyen Phu, additional, Koh, Tse Hsien, additional, Martins, Elisabete, additional, Mehershahi, Kurosh, additional, Newton, Paul, additional, Ng, Lee Ching, additional, Phuoc, Nguyen Ngoc, additional, Sangwichian, Ornuma, additional, Sawatwong, Pongpun, additional, Surin, Uraiwan, additional, Tan, Thean Yen, additional, Tang, Wen Ying, additional, Thuy, Nguyen Vu, additional, Turner, Paul, additional, Vongsouvath, Manivanh, additional, Zhang, Defeng, additional, Whistler, Toni, additional, and Chen, Swaine L., additional
- Published
- 2019
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3. Viral Aetiology of Central Nervous System Infections in Adults Admitted to a Tertiary Referral Hospital in Southern Vietnam over 12 Years
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Tan, Le Van, primary, Thai, Le Hong, additional, Phu, Nguyen Hoan, additional, Nghia, Ho Dang Trung, additional, Chuong, Ly Van, additional, Sinh, Dinh Xuan, additional, Phong, Nguyen Duy, additional, Mai, Nguyen Thi Hoang, additional, Man, Dinh Nguyen Huy, additional, Hien, Vo Minh, additional, Vinh, Nguyen Thanh, additional, Day, Jeremy, additional, Chau, Nguyen Van Vinh, additional, Hien, Tran Tinh, additional, Farrar, Jeremy, additional, de Jong, Menno D., additional, Thwaites, Guy, additional, van Doorn, H. Rogier, additional, and Chau, Tran Thi Hong, additional
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- 2014
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4. Viral Etiology of Encephalitis in Children in Southern Vietnam: Results of a One-Year Prospective Descriptive Study
- Author
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Tan, Le Van, primary, Qui, Phan Tu, additional, Ha, Do Quang, additional, Hue, Nguyen Bach, additional, Bao, Lam Quoi, additional, Cam, Bach Van, additional, Khanh, Truong Huu, additional, Hien, Tran Tinh, additional, Vinh Chau, Nguyen Van, additional, Tram, Tran Tan, additional, Hien, Vo Minh, additional, Nga, Tran Vu Thieu, additional, Schultsz, Constance, additional, Farrar, Jeremy, additional, van Doorn, H. Rogier, additional, and de Jong, Menno D., additional
- Published
- 2010
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5. Dengue Dynamics in Binh Thuan Province, Southern Vietnam: Periodicity, Synchronicity and Climate Variability
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Thai, Khoa T. D., primary, Cazelles, Bernard, additional, Nguyen, Nam Van, additional, Vo, Long Thi, additional, Boni, Maciej F., additional, Farrar, Jeremy, additional, Simmons, Cameron P., additional, van Doorn, H. Rogier, additional, and de Vries, Peter J., additional
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- 2010
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6. The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam
- Author
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Nhu, Nguyen Thi Khanh, primary, Vinh, Ha, additional, Nga, Tran Vu Thieu, additional, Stabler, Richard, additional, Duy, Pham Thanh, additional, Thi Minh Vien, Le, additional, van Doorn, H. Rogier, additional, Cerdeño-Tárraga, Ana, additional, Thomson, Nicholas, additional, Campbell, James, additional, Van Minh Hoang, Nguyen, additional, Thi Thu Nga, Tran, additional, Minh, Pham Van, additional, Thuy, Cao Thu, additional, Wren, Brendan, additional, Farrar, Jeremy, additional, and Baker, Stephen, additional
- Published
- 2010
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7. Viral Etiology of Encephalitis in Children in Southern Vietnam: Results of a One-Year Prospective Descriptive Study.
- Author
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Le Van Tan, Phan Tu Qui, Do Quang Ha, Nguyen Bach Hue, Lam Quoi Bao, Bach Van Cam, Truong Huu Khanh, Tran Tinh Hien, Nguyen Van Vinh Chau, Tran Tan Tram, Vo Minh Hien, Tran Vu Thieu Nga, Schultsz, Constance, Farrar, Jeremy, van Doorn, H. Rogier, and de Jong, Menno D.
- Subjects
ETIOLOGY of diseases ,ENCEPHALITIS ,JUVENILE diseases ,JAPANESE encephalitis viruses ,SEROLOGY ,POLYMERASE chain reaction ,HERPES simplex virus ,DISEASE risk factors - Abstract
Background: Acute encephalitis is an important and severe disease in children in Vietnam. However, little is known about the etiology while such knowledge is essential for optimal prevention and treatment. To identify viral causes of encephalitis, in 2004 we conducted a one-year descriptive study at Children's Hospital Number One, a referral hospital for children in southern Vietnam including Ho Chi Minh City. Methodology/Principal Findings: Children less than 16 years of age presenting with acute encephalitis of presumed viral etiology were enrolled. Diagnostic efforts included viral culture, serology and real time (RT)-PCRs. A confirmed or probable viral causative agent was established in 41% of 194 enrolled patients. The most commonly diagnosed causative agent was Japanese encephalitis virus (n = 50, 26%), followed by enteroviruses (n = 18, 9.3%), dengue virus (n = 9, 4.6%), herpes simplex virus (n = 1), cytomegalovirus (n = 1) and influenza A virus (n = 1). Fifty-seven (29%) children died acutely. Fatal outcome was independently associated with patient age and Glasgow Coma Scale (GCS) on admission. Conclusions/Significance: Acute encephalitis in children in southern Vietnam is associated with high mortality. Although the etiology remains unknown in a majority of the patients, the result from the present study may be useful for future design of treatment and prevention strategies of the disease. The recognition of GCS and age as predictive factors may be helpful for clinicians in managing the patient. [ABSTRACT FROM AUTHOR]
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- 2010
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8. The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam.
- Author
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Nhu, Nguyen Thi Khanh, Vinh, Ha, Nga, Tran Vu Thieu, Stabler, Richard, Duy, Pham Thanh, Thi Minh Vien, Le, van Doorn, H. Rogier, Cerdeño-Tárraga, Ana, Thomson, Nicholas, Campbell, James, Van Minh Hoang, Nguyen, Thi Thu Nga, Tran, Minh, Pham Van, Thuy, Cao Thu, Wren, Brendan, Farrar, Jeremy, and Baker, Stephen
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NUCLEIC acid hybridization ,SHIGELLOSIS ,SHIGELLA ,MICROBIAL sensitivity tests ,PLASMIDS ,KLEBSIELLA pneumoniae ,ENTEROBACTER cloacae - Abstract
Background: Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges. Methodology: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a bla
CTX–M encoding plasmid. Principal Findings: We show that two different blaCTX-M genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the blaCTX-M gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356) carried the blaCTX-M-24 gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids. Significance: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting. Author Summary: Shigellosis is a disease caused by bacteria belonging to Shigella spp. and is a leading cause of bacterial gastrointestinal infections in infants in unindustrialized countries. The Shigellae are dynamic and capable of rapid change when placed under selective pressure in a human population. Extended spectrum beta lactamases (ESBLs) are enzymes capable of degrading cephalosporins (a group of antimicrobial agents) and the genes that encode them are common in pathogenic E. coli and other related organisms in industrialized countries. In southern Vietnam, we have isolated multiple cephalosporin-resistant Shigella that express ESBLs. Furthermore, over two years these strains have replaced strains isolated from patients with shigellosis that cannot express ESBLs. Our work describes the genes responsible for this characteristic and we investigate one of the elements carrying one of these genes. These finding have implications for treatment of shigellosis and support the growing necessity for vaccine development. Our findings also may be pertinent for other countries undergoing a similar economic transition to Vietnam's and the corresponding effect on bacterial populations. [ABSTRACT FROM AUTHOR]- Published
- 2010
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- View/download PDF
9. The Sudden Dominance of blaCTX-M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam.
- Author
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Nguyen Thi Khanh Nhu, Ha Vinh, Tran Vu Thieu Nga, Stabler, Richard, Pham Thanh Duy, Le Thi Minh Vien, van Doorn, H. Rogier, Cerdeño-Tárraga, Ana, Thomson, Nicholas, Campbell, James, Nguyen Van Minh Hoang, Tran Thi Thu Nga, Pham Van Minh, Cao Thu Thuy, Wren, Brendan, Farrar, Jeremy, and Baker, Stephen
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PLASMIDS ,ENTEROBACTERIACEAE ,BETA lactamases ,MEDICAL care ,CEPHALOSPORINS ,ANTIBIOTICS ,HOMOLOGY (Biology) - Abstract
Background: Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges. Methodology: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a bla
encoding plasmid. Principal Findings: We show that two different blaCTX-M CTX-M genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the blaCTX-M gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356) carried the blaCTX-M -24 gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids. Significance: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
10. The sudden dominance of blaCTX-M harbouring plasmids in Shigella spp. Circulating in Southern Vietnam.
- Author
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Nguyen NT, Ha V, Tran NV, Stabler R, Pham DT, Le TM, van Doorn HR, Cerdeño-Tárraga A, Thomson N, Campbell J, Nguyen VM, Tran TT, Pham MV, Cao TT, Wren B, Farrar J, and Baker S
- Subjects
- Adolescent, Ceftriaxone pharmacology, Child, Child, Preschool, Cluster Analysis, Humans, Infant, Infant, Newborn, Polymerase Chain Reaction, Sequence Analysis, DNA, Shigella drug effects, Shigella pathogenicity, Vietnam, Bacterial Proteins genetics, Drug Resistance, Bacterial genetics, Dysentery, Bacillary epidemiology, Plasmids genetics, Shigella genetics, beta-Lactamases genetics
- Abstract
Background: Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges., Methodology: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a bla(CTX-M) encoding plasmid., Principal Findings: We show that two different bla(CTX-M) genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the bla(CTX-M) gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356) carried the bla(CTX-M-24) gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids., Significance: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting.
- Published
- 2010
- Full Text
- View/download PDF
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