1. Is Gestational Hypertension Protective against Perinatal Mortality in Twin Pregnancies?
- Author
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François Audibert, Zhong-Cheng Luo, Ji-Yan Zhang, Qi-Guang Luo, and Weiwei Cheng
- Subjects
Gestational hypertension ,Maternal Health ,lcsh:Medicine ,Blood Pressure ,Logistic regression ,Vascular Medicine ,Cohort Studies ,0302 clinical medicine ,Pregnancy ,Medicine and Health Sciences ,030212 general & internal medicine ,Young adult ,lcsh:Science ,Twin Pregnancy ,030219 obstetrics & reproductive medicine ,Multidisciplinary ,Obstetrics ,Mortality rate ,Obstetrics and Gynecology ,Stillbirth ,3. Good health ,Nephrology ,Research Design ,Hypertension ,Physical Sciences ,Female ,Statistics (Mathematics) ,Research Article ,Adult ,medicine.medical_specialty ,Clinical Research Design ,Birth weight ,Cardiology ,Biostatistics ,Research and Analysis Methods ,03 medical and health sciences ,Young Adult ,Hypertensive Disorders in Pregnancy ,medicine ,Humans ,Statistical Methods ,Survival analysis ,Perinatal Mortality ,Retrospective Studies ,Probability ,business.industry ,lcsh:R ,Infant, Newborn ,Hypertension, Pregnancy-Induced ,medicine.disease ,United States ,Pregnancy Complications ,Pregnancy, Twin ,Women's Health ,lcsh:Q ,business ,Mathematics - Abstract
Background Pregnancy-induced or gestational hypertension is a common pregnancy complication. Paradoxically, gestational hypertension has been associated with a protective effect against perinatal mortality in twin pregnancies in analytic models (logistic regression) without accounting for survival time. Whether this effect is real remains uncertain. This study aimed to validate the impact of gestational hypertension on perinatal mortality in twin pregnancies using a survival analysis approach. Methods This was a retrospective cohort study of 278,821 twin pregnancies, using the U.S. 1995–2000 matched multiple birth dataset (the largest dataset available for multiple births). Cox proportional hazard models were applied to estimate the adjusted hazard ratios (aHR) of perinatal death (stillbirth and neonatal death) comparing gestational hypertensive vs. non-hypertensive pregnancies controlling for maternal characteristics and twin cluster-level dependence. Results Comparing births in gestational hypertensive vs. non-hypertensive twin pregnancies, perinatal mortality rates were significantly lower (1.20% vs. 3.38%), so were neonatal mortality (0.72% vs. 2.30%) and stillbirth (0.48% vs. 1.10%) rates. The aHRs (95% confidence intervals) were 0.34 (0.31–0.38) for perinatal death, 0.31 (0.27–0.34) for neonatal death, and 0.45 (0.38–0.53) for stillbirth, respectively. The protective effect of gestational hypertension against perinatal death became weaker over advancing gestational age; the aHRs in very preterm (
- Published
- 2014