Search

Skin cancer has a significant impact on the lives of many individuals annually and is recognized as the most prevalent type of cancer. In the United States, an estimated annual incidence of approximately 3.5 million people receiving a diagnosis of skin cancer underscores its widespread prevalence. Furthermore, the prognosis for individuals afflicted with advancing stages of skin cancer experiences a substantial decline in survival rates. This paper is dedicated to aiding healthcare experts in distinguishing between benign and malignant skin cancer cases by employing a range of machine learning and deep learning techniques and different feature extractors and feature selectors to enhance the evaluation metrics. In this paper, different transfer learning models are employed as feature extractors, and to enhance the evaluation metrics, a feature selection layer is designed, which includes diverse techniques such as Univariate, Mutual Information, ANOVA, PCA, XGB, Lasso, Random Forest, and Variance. Among transfer models, DenseNet-201 was selected as the primary feature extractor to identify features from data. Subsequently, the Lasso method was applied for feature selection, utilizing diverse machine learning approaches such as MLP, XGB, RF, and NB. To optimize accuracy and precision, ensemble methods were employed to identify and enhance the best-performing models. The study provides accuracy and sensitivity rates of 87.72% and 92.15%, respectively. [ABSTRACT FROM AUTHOR]

Circular reinforced concrete wound glass fiber reinforced polymer (GFRP) columns and reinforced concrete filled GFRP columns are extensively utilized in civil engineering practice. Various factors influence the performance of these two types of GFRP columns, thereby impacting the whole project. Therefore, it is highly significant to establish the prediction models for ultimate displacement and ultimate bearing capacity to optimize the design of the two types of GFRP columns. In this study, based on the experiments conducted under different conditions on the two kinds of GFRP columns, automatic machine learning along with four other commonly used machine learning methods were employed for modeling to analyze how the column parameters (cross section shape, concrete strength, height of GFRP column, wound GFRP wall thickness, inner diameter of wound GFRP column) affect their performance. The differences in performance among these five machine learning methods were analyzed after modeling. Subsequently, we obtained the variation patterns in ultimate displacement and ultimate bearing capacity of the columns influenced by each parameter by testing the data using the optimal model. Based on these findings, the optimal design schemes for the two types of GFRP columns are proposed. The contribution of this paper is three-fold. First, AutoML sheds light on the automatic prediction of ultimate displacement and ultimate bearing capacity of GFRP column. Second, in this paper, two optimal design schemes of GFRP columns are proposed. Third, for AEC industrial practitioners, the whole process is automatic, accurate and less reliant on data expertise and the optimization design scheme proposed in the article is relatively scientific. [ABSTRACT FROM AUTHOR]

The rural B&B industry is a key component of rural tourism, local economic development, and the wider rural revitalization strategy. Despite the abundance of tourism resources in Yunnan, the B&B sector faces significant challenges. It is therefore imperative to accurately identify the most pressing issues within the current B&B industry and formulate appropriate solutions to advance Yunnan's rural revitalization efforts. This study uses recent reviews of rural B&Bs on Ctrip.com and employs machine learning techniques, including Bert, CNN, LSTM, and GRU, to identify the key management challenges currently facing Yunnan's rural B&B industry. An analysis is then conducted to identify the key stakeholders involved in the process of improving the management of Yunnan's B&Bs. To assess the willingness of each stakeholder to support the improvement of the rural B&B industry, this paper establishes a three-party evolutionary game model and examines the dynamic evolutionary process of management improvement within Yunnan's rural B&B industry. Two scenarios of evolutionarily stable strategies are analyzed, and parameters impacting stakeholders' strategy choices are simulated and evaluated. The results show that: i) Improving the "human factor" is the top priority for the current management improvement because tourists are most concerned about the emotional experience. Operators need to focus on improving service attitude and emotional experience; ii) The main stakeholders in the current management optimization process of Yunnan B&Bs are the local government, B&B operators, and tourists. Under appropriate conditions, the evolutionarily stable strategy of (1, 1, 1) is reachable. iii) variables such as additional costs, tourists' choice preferences, and government penalties significantly affect the strategy choices of stakeholders, especially B&B operators. This paper offers effective strategies for improving B&B management that can benefit the government, B&B operators, and tourists, and ultimately contribute to the promotion of quality rural revitalization. The paper not only identifies focal areas for improving B&B management in rural Yunnan, but also provides an in-depth understanding of stakeholder dynamics. As a result, it provides valuable insights to further the cause of quality rural revitalization. [ABSTRACT FROM AUTHOR]

In recent years, considerable and valuable research progress has been made in indoor positioning technologies based on WLAN Radio Frequency (RF) fingerprinting, identifying it as one of the most promising positioning technologies with substantial potential for wider adoption. However, indoor environmental factors significantly influence the propagation of wireless RF signals, resulting in a considerable decrease in positioning accuracy as the indoor environmental conditions vary. Thus, effectively mitigating the impact of indoor environmental factors on WLAN RF fingerprinting-based positioning systems has become a crucial research problem. Currently, there is a dearth of comprehensive research on the influence of indoor climatic factors, particularly the variations in relative humidity, on the propagation of WLAN RF signals within indoor spaces and its consequential impact on positioning accuracy. To address the aforementioned issues, this paper proposes an Adaptive expansion fingerprint database (AeFd) model based on a regression learning algorithm. The AeFd, through the design of a relationship model describing the interaction between fingerprint databases under varying relative humidity, allows the fingerprint database expanded by AeFd to dynamically adapt to the changes in indoor relative humidity. Our experiments show that using the AeFd model with the KNN algorithm, a 5% performance improvement was observed over 10 days and an 8% improvement over 10 months. According to experimental test results, the fingerprint database expansion model AeFd proposed in this paper can effectively expand the fingerprint database under different relative humidity levels, thereby significantly enhancing the positioning performance of the system and improving its stability. [ABSTRACT FROM AUTHOR]

Manifold visualisation techniques are commonly used to visualise high-dimensional datasets in physical sciences. In this paper, we apply a recently introduced manifold visualisation method, slisemap, on datasets from physics and chemistry. slisemap combines manifold visualisation with explainable artificial intelligence. Explainable artificial intelligence investigates the decision processes of black box machine learning models and complex simulators. With slisemap, we find an embedding such that data items with similar local explanations are grouped together. Hence, slisemap gives us an overview of the different behaviours of a black box model, where the patterns in the embedding reflect a target property. In this paper, we show how slisemap can be used and evaluated on physical data and that it is helpful in finding meaningful information on classification and regression models trained on these datasets. [ABSTRACT FROM AUTHOR]

The role of macrophages in regulating the tumor microenvironment has spurned the exponential generation of nanoparticle targeting technologies. With the large amount of literature and the speed at which it is generated it is difficult to remain current with the most up-to-date literature. In this study we performed a topic modeling analysis of 854 abstracts of peer-reviewed literature for the most common usages of nanoparticle targeting of tumor associated macrophages (TAMs) in solid tumors. The data spans 20 years of literature, providing a broad perspective of the nanoparticle strategies. Our topic model found 6 distinct topics: Immune and TAMs, Nanoparticles, Imaging, Gene Delivery and Exosomes, Vaccines, and Multi-modal Therapies. We also found distinct nanoparticle usage, tumor types, and therapeutic trends across these topics. Moreover, we established that the topic model could be used to assign new papers into the existing topics, thereby creating a Living Review. This type of "birds-eye-view" analysis provides a useful assessment tool for exploring new and emerging themes within a large field. [ABSTRACT FROM AUTHOR]

International students' mental health has become an increasing concern in recent years, as more students leave their country for better education. They experience a wide range of challenges while studying abroad that have an impact on their psychological well-being. These challenges can include language obstacles, cultural differences, homesickness, financial issues and other elements that could severely impact the mental health of international students. Given the limited research on the demographic, cultural, and psychosocial variables that influence international students' mental health, and the scarcity of studies on the use of machine learning algorithms in this area, this study aimed to analyse data to understand the demographic, cultural factors, and psychosocial factors that impact mental health of international students. Additionally, this paper aimed to build a machine learning-based model for predicting depression among international students in the United Kingdom. This study utilized both primary data gathered through an online survey questionnaire targeted at international students and secondary data was sourced from the 'A Dataset of Students' Mental Health and Help-Seeking Behaviors in a Multicultural Environment,' focusing exclusively on international student data within this dataset. We conducted data analysis on the primary data and constructed models using the secondary data for predicting depression among international students. The secondary dataset is divided into training (70%) and testing (30%) sets for analysis, employing four machine learning models: Logistic Regression, Decision Tree, Random Forest, and K Nearest Neighbor. To assess each algorithm's performance, we considered metrics such as Accuracy, Sensitivity, Specificity, Precision and AU-ROC curve. This study identifies significant demographic variables (e.g., loan status, gender, age, marital status) and psychosocial factors (financial difficulties, academic stress, homesickness, loneliness) contributing to international students' mental health. Among the machine learning models, the Random Forest model demonstrated the highest accuracy, achieving an 80% accuracy rate in predicting depression. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic prompted governments worldwide to implement a range of containment measures, including mass gathering restrictions, social distancing, and school closures. Despite these efforts, vaccines continue to be the safest and most effective means of combating such viruses. Yet, vaccine hesitancy persists, posing a significant public health concern, particularly with the emergence of new COVID-19 variants. To effectively address this issue, timely data is crucial for understanding the various factors contributing to vaccine hesitancy. While previous research has largely relied on traditional surveys for this information, recent sources of data, such as social media, have gained attention. However, the potential of social media data as a reliable proxy for information on population hesitancy, especially when compared with survey data, remains underexplored. This paper aims to bridge this gap. Our approach uses social, demographic, and economic data to predict vaccine hesitancy levels in the ten most populous US metropolitan areas. We employ machine learning algorithms to compare a set of baseline models that contain only these variables with models that incorporate survey data and social media data separately. Our results show that XGBoost algorithm consistently outperforms Random Forest and Linear Regression, with marginal differences between Random Forest and XGBoost. This was especially the case with models that incorporate survey or social media data, thus highlighting the promise of the latter data as a complementary information source. Results also reveal variations in influential variables across the five hesitancy classes, such as age, ethnicity, occupation, and political inclination. Further, the application of models to different MSAs yields mixed results, emphasizing the uniqueness of communities and the need for complementary data approaches. In summary, this study underscores social media data's potential for understanding vaccine hesitancy, emphasizes the importance of tailoring interventions to specific communities, and suggests the value of combining different data sources. [ABSTRACT FROM AUTHOR]

The ever-increasing demand for electricity has presented a grave threat to traditional energy sources, which are finite, rapidly depleting, and have a detrimental environmental impact. These shortcomings of conventional energy resources have caused the globe to switch from traditional to renewable energy sources. Wind power significantly contributes to carbon-free energy because it is widely accessible, inexpensive, and produces no harmful emissions. Better and more efficient renewable wind power production relies on accurate wind speed predictions. Accurate short-term wind speed forecasting is essential for effectively handling unsteady wind power generation and ensuring that wind turbines operate safely. The significant stochastic nature of the wind speed and its dynamic unpredictability makes it difficult to forecast. This paper develops a hybrid model, L-LG-S, for precise short-term wind speed forecasting to address problems in wind speed forecasting. In this research, state-of-the-art machine learning and deep learning algorithms employed in wind speed forecasting are compared with the proposed approach. The effectiveness of the proposed hybrid model is tested using real-world wind speed data from a wind turbine located in the city of Karachi, Pakistan. Moreover, the mean square error (MSE), root mean square error (RMSE), and mean absolute error (MAE) are used as accuracy evaluation indices. Experimental results show that the proposed model outperforms the state-of-the-art legacy models in terms of accuracy for short-term wind speed in training, validation and test predictions by 98% respectively. [ABSTRACT FROM AUTHOR]

Thyroid disease classification plays a crucial role in early diagnosis and effective treatment of thyroid disorders. Machine learning (ML) techniques have demonstrated remarkable potential in this domain, offering accurate and efficient diagnostic tools. Most of the real-life datasets have imbalanced characteristics that hamper the overall performance of the classifiers. Existing data balancing techniques process the whole dataset at a time that sometimes causes overfitting and underfitting. However, the complexity of some ML models, often referred to as "black boxes," raises concerns about their interpretability and clinical applicability. This paper presents a comprehensive study focused on the analysis and interpretability of various ML models for classifying thyroid diseases. In our work, we first applied a new data-balancing mechanism using a clustering technique and then analyzed the performance of different ML algorithms. To address the interpretability challenge, we explored techniques for model explanation and feature importance analysis using eXplainable Artificial Intelligence (XAI) tools globally as well as locally. Finally, the XAI results are validated with the domain experts. Experimental results have shown that our proposed mechanism is efficient in diagnosing thyroid disease and can explain the models effectively. The findings can contribute to bridging the gap between adopting advanced ML techniques and the clinical requirements of transparency and accountability in diagnostic decision-making. [ABSTRACT FROM AUTHOR]

Diabetes is a persistent metabolic disorder linked to elevated levels of blood glucose, commonly referred to as blood sugar. This condition can have detrimental effects on the heart, blood vessels, eyes, kidneys, and nerves as time passes. It is a chronic ailment that arises when the body fails to produce enough insulin or is unable to effectively use the insulin it produces. When diabetes is not properly managed, it often leads to hyperglycemia, a condition characterized by elevated blood sugar levels or impaired glucose tolerance. This can result in significant harm to various body systems, including the nerves and blood vessels. In this paper, we propose a multiclass diabetes mellitus detection and classification approach using an extremely imbalanced Laboratory of Medical City Hospital data dynamics. We also formulate a new dataset that is moderately imbalanced based on the Laboratory of Medical City Hospital data dynamics. To correctly identify the multiclass diabetes mellitus, we employ three machine learning classifiers namely support vector machine, logistic regression, and k-nearest neighbor. We also focus on dimensionality reduction (feature selection—filter, wrapper, and embedded method) to prune the unnecessary features and to scale up the classification performance. To optimize the classification performance of classifiers, we tune the model by hyperparameter optimization with 10-fold grid search cross-validation. In the case of the original extremely imbalanced dataset with 70:30 partition and support vector machine classifier, we achieved maximum accuracy of 0.964, precision of 0.968, recall of 0.964, F1-score of 0.962, Cohen kappa of 0.835, and AUC of 0.99 by using top 4 feature according to filter method. By using the top 9 features according to wrapper-based sequential feature selection, the k-nearest neighbor provides an accuracy of 0.935 and 1.0 for the other performance metrics. For our created moderately imbalanced dataset with an 80:20 partition, the SVM classifier achieves a maximum accuracy of 0.938, and 1.0 for other performance metrics. For the multiclass diabetes mellitus detection and classification, our experiments outperformed conducted research based on the Laboratory of Medical City Hospital data dynamics. [ABSTRACT FROM AUTHOR]

Southern leaf blight (SLB) is a foliar disease caused by the fungus Cochliobolus heterostrophus infecting maize plants in humid, warm weather conditions. SLB causes production losses to corn producers in different regions of the world such as Latin America, Europe, India, and Africa. In this paper, we demonstrate a non-destructive method to quantify the signs of fungal infection in SLB-infected corn plants using a deep UV (DUV) fluorescence spectrometer, with a 248.6 nm excitation wavelength, to acquire the emission spectra of healthy and SLB-infected corn leaves. Fluorescence emission spectra of healthy and diseased leaves were used to train an Autoencoder (AE) anomaly detection algorithm—an unsupervised machine learning model—to quantify the phenotype associated with SLB-infected leaves. For all samples, the signature of corn leaves consisted of two prominent peaks around 450 nm and 325 nm. However, SLB-infected leaves showed a higher response at 325 nm compared to healthy leaves, which was correlated to the presence of C. heterostrophus based on disease severity ratings from Visual Scores (VS). Specifically, we observed a linear inverse relationship between the AE error and the VS (R2 = 0.94 and RMSE = 0.935). With improved hardware, this method may enable improved quantification of SLB infection versus visual scoring based on e.g., fungal spore concentration per unit area and spatial localization. [ABSTRACT FROM AUTHOR]

Many lumbar spine diseases are caused by defects or degeneration of lumbar intervertebral discs (IVD) and are usually diagnosed through inspection of the patient's lumbar spine MRI. Efficient and accurate assessments of the lumbar spine are essential but a challenge due to the size of the clinical radiologist workforce not keeping pace with the demand for radiology services. In this paper, we present a methodology to automatically annotate lumbar spine IVDs with their height and degenerative state which is quantified using the Pfirrmann grading system. The method starts with semantic segmentation of a mid-sagittal MRI image into six distinct non-overlapping regions, including the IVD and vertebrae regions. Each IVD region is then located and assigned with its label. Using geometry, a line segment bisecting the IVD is determined and its Euclidean distance is used as the IVD height. We then extract an image feature, called self-similar color correlogram, from the nucleus of the IVD region as a representation of the region's spatial pixel intensity distribution. We then use the IVD height data and machine learning classification process to predict the Pfirrmann grade of the IVD. We considered five different deep learning networks and six different machine learning algorithms in our experiment and found the ResNet-50 model and Ensemble of Decision Trees classifier to be the combination that gives the best results. When tested using a dataset containing 515 MRI studies, we achieved a mean accuracy of 88.1%. [ABSTRACT FROM AUTHOR]

This paper presents an optimized preparation process for external ointment using the Definitive Screening Design (DSD) method. The ointment is a Traditional Chinese Medicine (TCM) formula developed by Professor WYH, a renowned TCM practitioner in Jiangsu Province, China, known for its proven clinical efficacy. In this study, a stepwise regression model was employed to analyze the relationship between key process factors (such as mixing speed and time) and rheological parameters. Machine learning techniques, including Monte Carlo simulation, decision tree analysis, and Gaussian process, were used for parameter optimization. Through rigorous experimentation and verification, we have successfully identified the optimal preparation process for WYH ointment. The optimized parameters included drug ratio of 24.5%, mixing time of 8 min, mixing speed of 1175 rpm, petroleum dosage of 79 g, liquid paraffin dosage of 6.7 g. The final ointment formulation was prepared using method B. This research not only contributes to the optimization of the WYH ointment preparation process but also provides valuable insights and practical guidance for designing the preparation processes of other TCM ointments. This advanced DSD method enhances the screening approach for identifying the best preparation process, thereby improving the scientific rigor and quality of TCM ointment preparation processes. [ABSTRACT FROM AUTHOR]

With recent technological advancements, quantitative analysis has become an increasingly important area within professional sports. However, the manual process of collecting data on relevant match events like passes, goals and tacklings comes with considerable costs and limited consistency across providers, affecting both research and practice. In football, while automatic detection of events from positional data of the players and the ball could alleviate these issues, it is not entirely clear what accuracy current state-of-the-art methods realistically achieve because there is a lack of high-quality validations on realistic and diverse data sets. This paper adds context to existing research by validating a two-step rule-based pass and shot detection algorithm on four different data sets using a comprehensive validation routine that accounts for the temporal, hierarchical and imbalanced nature of the task. Our evaluation shows that pass and shot detection performance is highly dependent on the specifics of the data set. In accordance with previous studies, we achieve F-scores of up to 0.92 for passes, but only when there is an inherent dependency between event and positional data. We find a significantly lower accuracy with F-scores of 0.71 for passes and 0.65 for shots if event and positional data are independent. This result, together with a critical evaluation of existing methodologies, suggests that the accuracy of current football event detection algorithms operating on positional data is currently overestimated. Further analysis reveals that the temporal extraction of passes and shots from positional data poses the main challenge for rule-based approaches. Our results further indicate that the classification of plays into shots and passes is a relatively straightforward task, achieving F-scores between 0.83 to 0.91 ro rule-based classifiers and up to 0.95 for machine learning classifiers. We show that there exist simple classifiers that accurately differentiate shots from passes in different data sets using a low number of human-understandable rules. Operating on basic spatial features, our classifiers provide a simple, objective event definition that can be used as a foundation for more reliable event-based match analysis. [ABSTRACT FROM AUTHOR]

Internet finance has permeated into myriad households, bringing about lifestyle convenience alongside potential risks. Presently, internet finance enterprises are progressively adopting machine learning and other artificial intelligence methods for risk alertness. What is the current status of the application of various machine learning models and algorithms across different institutions? Is there an optimal machine learning algorithm suited for the majority of internet finance platforms and application scenarios? Scholars have embarked on a series of studies addressing these questions; however, the focus predominantly lies in comparing different algorithms within specific platforms and contexts, lacking a comprehensive discourse and summary on the utilization of machine learning in this domain. Thus, based on the data from Web of Science and Scopus databases, this paper conducts a systematic literature review on all aspects of machine learning in internet finance risk in recent years, based on publications trends, geographical distribution, literature focus, machine learning models and algorithms, and evaluations. The research reveals that machine learning, as a nascent technology, whether through basic algorithms or intricate algorithmic combinations, has made significant strides compared to traditional credit scoring methods in predicting accuracy, time efficiency, and robustness in internet finance risk management. Nonetheless, there exist noticeable disparities among different algorithms, and factors such as model structure, sample data, and parameter settings also influence prediction accuracy, although generally, updated algorithms tend to achieve higher accuracy. Consequently, there is no one-size-fits-all approach applicable to all platforms; each platform should enhance its machine learning models and algorithms based on its unique characteristics, data, and the development of AI technology, starting from key evaluation indicators to mitigate internet finance risks. [ABSTRACT FROM AUTHOR]

Debris flow is a sudden natural disaster in mountainous areas, which seriously threatens the lives and property of nearby residents. Therefore, it is necessary to predict the volume of debris flow accurately and reliably. However, the predictions of back propagation neural networks are unstable and inaccurate due to the limited dataset. In this study, the Cubic map optimizes the initial population position of the whale optimization algorithm. Meanwhile, the adaptive weight adjustment strategy optimizes the weight value in the shrink-wrapping mechanism of the whale optimization algorithm. Then, the improved whale optimization algorithm optimizes the final weights and thresholds in the back propagation neural network. Finally, to verify the performance of the final model, sixty debris flow gullies caused by earthquakes in Longmenshan area are selected as the research objects. Through correlation analysis, 4 main factors affecting the volume of debris flow are determined and inputted into the model for training and prediction. Four methods (support vector machine regression, XGBoost, back propagation neural network optimized by artificial bee colony algorithm, back propagation neural network optimized by grey wolf optimization algorithm) are used to compare the prediction performance and reliability. The results indicate that loose sediments from co-seismic landslides are the most important factor influencing the flow of debris flows in the earthquake area. The mean absolute percentage error, mean absolute error and R2 of the final model are 0.193, 29.197 × 104 m3 and 0.912, respectively. The final model is more accurate and stable when the dataset is insufficient and under complexity. This is attributed to the optimization of WOA by Cubic map and adaptive weight adjustment. In general, the model of this paper can provide reference for debris flow prevention and machine learning algorithms. [ABSTRACT FROM AUTHOR]

Recent advances in the field of machine learning have yielded novel research perspectives in behavioural economics and financial markets microstructure studies. In this paper we study the impact of individual trader leaning characteristics on markets using a stock market simulator designed with a multi-agent architecture. Each agent, representing an autonomous investor, trades stocks through reinforcement learning, using a centralized double-auction limit order book. This approach allows us to study the impact of individual trader traits on the whole stock market at the mesoscale in a bottom-up approach. We chose to test three trader trait aspects: agent learning rate increases, herding behaviour and random trading. As hypothesized, we find that larger learning rates significantly increase the number of crashes. We also find that herding behaviour undermines market stability, while random trading tends to preserve it. [ABSTRACT FROM AUTHOR]

Major depressive disorder (MDD), a prevalent mental health issue, affects more than 8% of the US population, and almost 17% in the young group of 18–25 years old. Since Covid-19, its prevalence has become even more significant. However, the remission (being free of depression) rates of first-line antidepressant treatments on MDD are only about 30%. To improve treatment outcomes, researchers have built various predictive models for treatment responses and yet none of them have been adopted in clinical use. One reason is that most predictive models are based on data from subjective questionnaires, which are less reliable. Neuroimaging data are promising objective prognostic factors, but they are expensive to obtain and hence predictive models using neuroimaging data are limited and such studies were usually in small scale (N<100). In this paper, we proposed an advanced machine learning (ML) pipeline for small training dataset with large number of features. We implemented multiple imputation for missing data and repeated K-fold cross validation (CV) to robustly estimate predictive performances. Different feature selection methods and stacking methods using 6 general ML models including random forest, gradient boosting decision tree, XGBoost, penalized logistic regression, support vector machine (SVM), and neural network were examined to evaluate the model performances. All predictive models were compared using model performance metrics such as accuracy, balanced accuracy, area under ROC curve (AUC), sensitivity and specificity. Our proposed ML pipeline was applied to a training dataset and obtained an accuracy and AUC above 0.80. But such high performance failed while applying our ML pipeline using an external validation dataset from the EMBARC study which is a multi-center study. We further examined the possible reasons especially the site heterogeneity issue. [ABSTRACT FROM AUTHOR]

Mechanical ventilation techniques are vital for preserving individuals with a serious condition lives in the prolonged hospitalization unit. Nevertheless, an imbalance amid the hospitalized people demands and the respiratory structure could cause to inconsistencies in the patient's inhalation. To tackle this problem, this study presents an Iterative Learning PID Controller (ILC-PID), a unique current cycle feedback type controller that helps in gaining the correct pressure and volume. The paper also offers a clear and complete examination of the primarily efficient neural approach for generating optimal inhalation strategies. Moreover, machine learning-based classifiers are used to evaluate the precision and performance of the ILC-PID controller. These classifiers able to forecast and choose the perfect type for various inhalation modes, eliminating the likelihood that patients will require mechanical ventilation. In pressure control, the suggested accurate neural categorization exhibited an average accuracy rate of 88.2% in continuous positive airway pressure (CPAP) mode and 91.7% in proportional assist ventilation (PAV) mode while comparing with the other classifiers like ensemble classifier has reduced accuracy rate of 69.5% in CPAP mode and also 71.7% in PAV mode. An average accuracy of 78.9% rate in other classifiers compared to neutral network in CPAP. The neural model had an typical range of 81.6% in CPAP mode and 84.59% in PAV mode for 20 cm H2O of volume created by the neural network classifier in the volume investigation. Compared to the other classifiers, an average of 72.17% was in CPAP mode, and 77.83% was in PAV mode in volume control. Different approaches, such as decision trees, optimizable Bayes trees, naive Bayes trees, nearest neighbour trees, and an ensemble of trees, were also evaluated regarding the accuracy by confusion matrix concept, training duration, specificity, sensitivity, and F1 score. [ABSTRACT FROM AUTHOR]

Slow patient enrollment or failing to enroll the required number of patients is a disruptor of clinical trial timelines. To meet the planned trial recruitment, site selection strategies are used during clinical trial planning to identify research sites that are most likely to recruit a sufficiently high number of subjects within trial timelines. We developed a machine learning approach that outperforms baseline methods to rank research sites based on their expected recruitment in future studies. Indication level historical recruitment and real-world data are used in the machine learning approach to predict patient enrollment at site level. We define covariates based on published recruitment hypotheses and examine the effect of these covariates in predicting patient enrollment. We compare model performance of a linear and a non-linear machine learning model with common industry baselines that are constructed from historical recruitment data. Performance of the methodology is evaluated and reported for two disease indications, inflammatory bowel disease and multiple myeloma, both of which are actively being pursued in clinical development. We validate recruitment hypotheses by reviewing the covariates relationship with patient recruitment. For both indications, the non-linear model significantly outperforms the baselines and the linear model on the test set. In this paper, we present a machine learning approach to site selection that incorporates site-level recruitment and real-world patient data. The model ranks research sites by predicting the number of recruited patients and our results suggest that the model can improve site ranking compared to common industry baselines. [ABSTRACT FROM AUTHOR]

Background: Thrombus formation in vitro under flow conditions is one of the most widely used methods to study haemostasis and to evaluate the activity of potential antithrombotic compounds. Assessment of the results of these experiments is often based on a quantification of microscopic images of thrombi. In a majority of reported analysis all thrombi visualised in an image are quantified as one homogenous class. In some protocols, qualitative assessment of thrombi morphology based on a visual comparison of evaluated images with representative images of predefined classes of thrombi are performed by experienced analysts. In presented paper we show how the quantitative analysis can be improved by classification of thrombi on the basis of defined morphological features prior to quantification and we suggest that machine learning-based approach can improve this way of analysis. Methods: We tested the applicability of machine learning-based segmentation and classification of thrombi images to improve the outcome of quantification of the results of flow chamber assays. For this, we used the public domain machine learning software Ilastik for bioimage analysis developed at the European Molecular Biology Laboratory. A model was trained to distinguish two classes of thrombi based on certain morphological features which apparently correspond to the stage of thrombus development. Thrombi formed in the presence of a model antiplatelet compound—abciximab or in control conditions were quantified with the use of this model and the results were compared to quantification where all thrombi were quantified as a homogenous class. Results: Machine learning-based analysis was capable of effective distinguishing of two classes of morphologically distinct platelet aggregates. The use of the model which segmented and quantified only the objects recognized as compacted structures provided results which better mirrored the actual effect of an antiplatelet treatment than quantification based on all structures. Conclusions: Classification of thrombi enabled by machine learning increases the relevance of quantitative information and allows better evaluation of the results of in vitro thrombosis assays. [ABSTRACT FROM AUTHOR]

Background: Cancer diagnosis based on machine learning has become a popular application direction. Support vector machine (SVM), as a classical machine learning algorithm, has been widely used in cancer diagnosis because of its advantages in high-dimensional and small sample data. However, due to the high-dimensional feature space and high feature redundancy of gene expression data, SVM faces the problem of poor classification effect when dealing with such data. Methods: Based on this, this paper proposes a hybrid feature selection algorithm combining information gain and grouping particle swarm optimization (IG-GPSO). The algorithm firstly calculates the information gain values of the features and ranks them in descending order according to the value. Then, ranked features are grouped according to the information index, so that the features in the group are close, and the features outside the group are sparse. Finally, grouped features are searched using grouping PSO and evaluated according to in-group and out-group. Results: Experimental results show that the average accuracy (ACC) of the SVM on the feature subset selected by the IG-GPSO is 98.50%, which is significantly better than the traditional feature selection algorithm. Compared with KNN, the classification effect of the feature subset selected by the IG-GPSO is still optimal. In addition, the results of multiple comparison tests show that the feature selection effect of the IG-GPSO is significantly better than that of traditional feature selection algorithms. Conclusion: The feature subset selected by IG-GPSO not only has the best classification effect, but also has the least feature scale (FS). More importantly, the IG-GPSO significantly improves the ACC of SVM in cancer diagnostic. [ABSTRACT FROM AUTHOR]

Credit card fraud is a significant problem that costs billions of dollars annually. Detecting fraudulent transactions is challenging due to the imbalance in class distribution, where the majority of transactions are legitimate. While pre-processing techniques such as oversampling of minority classes are commonly used to address this issue, they often generate unrealistic or overgeneralized samples. This paper proposes a method called autoencoder with probabilistic xgboost based on SMOTE and CGAN(AE-XGB-SMOTE-CGAN) for detecting credit card frauds.AE-XGB-SMOTE-CGAN is a novel method proposed for credit card fraud detection problems. The credit card fraud dataset comes from a real dataset anonymized by a bank and is highly imbalanced, with normal data far greater than fraud data. Autoencoder (AE) is used to extract relevant features from the dataset, enhancing the ability of feature representation learning, and are then fed into xgboost for classification according to the threshold. Additionally, in this study, we propose a novel approach that hybridizes Generative Adversarial Network (GAN) and Synthetic Minority Over-Sampling Technique (SMOTE) to tackle class imbalance problems. Our two-phase oversampling approach involves knowledge transfer and leverages the synergies of SMOTE and GAN. Specifically, GAN transforms the unrealistic or overgeneralized samples generated by SMOTE into realistic data distributions where there is not enough minority class data available for GAN to process effectively on its own. SMOTE is used to address class imbalance issues and CGAN is used to generate new, realistic data to supplement the original dataset. The AE-XGB-SMOTE-CGAN algorithm is also compared to other commonly used machine learning algorithms, such as KNN and Light GBM, and shows an overall improvement of 2% in terms of the ACC index compared to these algorithms. The AE-XGB-SMOTE-CGAN algorithm also outperforms KNN in terms of the MCC index by 30% when the threshold is set to 0.35. This indicates that the AE-XGB-SMOTE-CGAN algorithm has higher accuracy, true positive rate, true negative rate, and Matthew's correlation coefficient, making it a promising method for detecting credit card fraud. [ABSTRACT FROM AUTHOR]

Coal pillar retention plays a crucial role in ensuring safety and minimizing ground deformation in coal mining operations. However, accurately and efficiently determining the optimal size of protective pillars, reducing coal pillar pressure, and addressing challenges such as limited access to retention parameters, lengthy observation times, and high labor costs are challenges that must be addressed. In this paper, we presented a methodology using Huainan mine as a case study to address these challenges. The solution involves deriving the formula for coal pillar retention parameters based on the Three Regulations definition and requirements. The total least squares algorithm was integrated with surface observation station data and the MATLAB software platform to automate the coal pillar retention solution. Furthermore, a linear regression model of coal pillar retention-related parameters was established using the geological mining condition data. The proposed ELM neural network model was optimized using a genetic algorithm and combined with the linear regression model to establish a predictive model. The results demonstrated that the proposed machine learning algorithm attains the requisite level of accuracy for industrial production. [ABSTRACT FROM AUTHOR]

The prediction of tweets associated with specific topics offers the potential to automatically focus on and understand online discussions surrounding these issues. This paper introduces a comprehensive approach that centers on the topic of "harm reduction" within the broader context of tobacco control. The study leveraged tweets from the period surrounding the ninth Conference of the Parties to review the Framework Convention on Tobacco Control (COP9) as a case study to pilot this approach. By using Latent Dirichlet Allocation (LDA)-based topic modeling, the study successfully categorized tweets related to harm reduction. Subsequently, various machine learning techniques were employed to predict these topics, achieving a prediction accuracy of 91.87% using the Random Forest algorithm. Additionally, the study explored correlations between retweets and sentiment scores. It also conducted a toxicity analysis to understand the extent to which online conversations lacked neutrality. Understanding the topics, sentiment, and toxicity of Twitter data is crucial for identifying public opinion and its formation. By specifically focusing on the topic of "harm reduction" in tweets related to COP9, the findings offer valuable insights into online discussions surrounding tobacco control. This understanding can aid policymakers in effectively informing the public and garnering public support, ultimately contributing to the successful implementation of tobacco control policies. [ABSTRACT FROM AUTHOR]

A crucial part of sentiment classification is featuring extraction because it involves extracting valuable information from text data, which affects the model's performance. The goal of this paper is to help in selecting a suitable feature extraction method to enhance the performance of sentiment analysis tasks. In order to provide directions for future machine learning and feature extraction research, it is important to analyze and summarize feature extraction techniques methodically from a machine learning standpoint. There are several methods under consideration, including Bag-of-words (BOW), Word2Vector, N-gram, Term Frequency- Inverse Document Frequency (TF-IDF), Hashing Vectorizer (HV), and Global vector for word representation (GloVe). To prove the ability of each feature extractor, we applied it to the Twitter US airlines and Amazon musical instrument reviews datasets. Finally, we trained a random forest classifier using 70% of the training data and 30% of the testing data, enabling us to evaluate and compare the performance using different metrics. Based on our results, we find that the TD-IDF technique demonstrates superior performance, with an accuracy of 99% in the Amazon reviews dataset and 96% in the Twitter US airlines dataset. This study underscores the paramount significance of feature extraction in sentiment analysis, endowing pragmatic insights to elevate model performance and steer future research pursuits. [ABSTRACT FROM AUTHOR]

Atypical visual attention in individuals with autism spectrum disorders (ASD) has been utilised as a unique diagnosis criterion in previous research. This paper presents a novel approach to the automatic and quantitative screening of ASD as well as symptom severity prediction in preschool children. We develop a novel computational pipeline that extracts learned features from a dynamic visual stimulus to classify ASD children and predict the level of ASD-related symptoms. Experimental results demonstrate promising performance that is superior to using handcrafted features and machine learning algorithms, in terms of evaluation metrics used in diagnostic tests. Using a leave-one-out cross-validation approach, we obtained an accuracy of 94.59%, a sensitivity of 100%, a specificity of 76.47% and an area under the receiver operating characteristic curve (AUC) of 96% for ASD classification. In addition, we obtained an accuracy of 94.74%, a sensitivity of 87.50%, a specificity of 100% and an AUC of 99% for ASD symptom severity prediction. [ABSTRACT FROM AUTHOR]

This paper presents a multi-algorithm fusion model (StackingGroup) based on the Stacking ensemble learning framework to address the variable selection problem in high-dimensional group structure data. The proposed algorithm takes into account the differences in data observation and training principles of different algorithms. It leverages the strengths of each model and incorporates Stacking ensemble learning with multiple group structure regularization methods. The main approach involves dividing the data set into K parts on average, using more than 10 algorithms as basic learning models, and selecting the base learner based on low correlation, strong prediction ability, and small model error. Finally, we selected the grSubset + grLasso, grLasso, and grSCAD algorithms as the base learners for the Stacking algorithm. The Lasso algorithm was used as the meta-learner to create a comprehensive algorithm called StackingGroup. This algorithm is designed to handle high-dimensional group structure data. Simulation experiments showed that the proposed method outperformed other R2, RMSE, and MAE prediction methods. Lastly, we applied the proposed algorithm to investigate the risk factors of low birth weight in infants and young children. The final results demonstrate that the proposed method achieves a mean absolute error (MAE) of 0.508 and a root mean square error (RMSE) of 0.668. The obtained values are smaller compared to those obtained from a single model, indicating that the proposed method surpasses other algorithms in terms of prediction accuracy. [ABSTRACT FROM AUTHOR]

Imagine having a knowledge graph that can extract medical health knowledge related to patient diagnosis solutions and treatments from thousands of research papers, distilled using machine learning techniques in healthcare applications. Medical doctors can quickly determine treatments and medications for urgent patients, while researchers can discover innovative treatments for existing and unknown diseases. This would be incredible! Our approach serves as an all-in-one solution, enabling users to employ a unified design methodology for creating their own knowledge graphs. Our rigorous validation process involves multiple stages of refinement, ensuring that the resulting answers are of the utmost professionalism and solidity, surpassing the capabilities of other solutions. However, building a high-quality knowledge graph from scratch, with complete triplets consisting of subject entities, relations, and object entities, is a complex and important task that requires a systematic approach. To address this, we have developed a comprehensive design flow for knowledge graph development and a high-quality entities database. We also developed knowledge distillation schemes that allow you to input a keyword (entity) and display all related entities and relations. Our proprietary methodology, multiple levels refinement (MLR), is a novel approach to constructing knowledge graphs and refining entities level-by-level. This ensures the generation of high-quality triplets and a readable knowledge graph through keyword searching. We have generated multiple knowledge graphs and developed a scheme to find the corresponding inputs and outputs of entity linking. Entities with multiple inputs and outputs are referred to as joints, and we have created a joint-version knowledge graph based on this. Additionally, we developed an interactive knowledge graph, providing a user-friendly environment for medical professionals to explore entities related to existing or unknown treatments/diseases. Finally, we have advanced knowledge distillation techniques. [ABSTRACT FROM AUTHOR]

Machine learning was shown to be effective at identifying distinctive genomic signatures among viral sequences. These signatures are defined as pervasive motifs in the viral genome that allow discrimination between species or variants. In the context of SARS-CoV-2, the identification of these signatures can assist in taxonomic and phylogenetic studies, improve in the recognition and definition of emerging variants, and aid in the characterization of functional properties of polymorphic gene products. In this paper, we assess KEVOLVE, an approach based on a genetic algorithm with a machine-learning kernel, to identify multiple genomic signatures based on minimal sets of k-mers. In a comparative study, in which we analyzed large SARS-CoV-2 genome dataset, KEVOLVE was more effective at identifying variant-discriminative signatures than several gold-standard statistical tools. Subsequently, these signatures were characterized using a new extension of KEVOLVE (KANALYZER) to highlight variations of the discriminative signatures among different classes of variants, their genomic location, and the mutations involved. The majority of identified signatures were associated with known mutations among the different variants, in terms of functional and pathological impact based on available literature. Here we showed that KEVOLVE is a robust machine learning approach to identify discriminative signatures among SARS-CoV-2 variants, which are frequently also biologically relevant, while bypassing multiple sequence alignments. The source code of the method and additional resources are available at: https://github.com/bioinfoUQAM/KEVOLVE. [ABSTRACT FROM AUTHOR]

Machine learning methods and agent-based models enable the optimization of the operation of high-capacity facilities. In this paper, we propose a method for automatically extracting and cleaning pedestrian traffic detector data for subsequent calibration of the ingress pedestrian model. The data was obtained from the waiting room traffic of a vaccination center. Walking speed distribution, the number of stops, the distribution of waiting times, and the locations of waiting points were extracted. Of the 9 machine learning algorithms, the random forest model achieved the highest accuracy in classifying valid data and noise. The proposed microscopic calibration allows for more accurate capacity assessment testing, procedural changes testing, and geometric modifications testing in parts of the facility adjacent to the calibrated parts. The results show that the proposed method achieves state-of-the-art performance on a violent-flows dataset. The proposed method has the potential to significantly improve the accuracy and efficiency of input model predictions and optimize the operation of high-capacity facilities. [ABSTRACT FROM AUTHOR]

The paper presents an algorithm to approach the problem of Maximum Clique Enumeration, a well known NP-hard problem that have several real world applications. The proposed solution, called LGP-MCE, exploits Geometric Deep Learning, a Machine Learning technique on graphs, to filter out nodes that do not belong to maximum cliques and then applies an exact algorithm to the pruned network. To assess the LGP-MCE, we conducted multiple experiments using a substantial dataset of real-world networks, varying in size, density, and other characteristics. We show that LGP-MCE is able to drastically reduce the running time, while retaining all the maximum cliques. [ABSTRACT FROM AUTHOR]

The relationship between morphological traits and ecological performance in birds is an important area of research, as it can help us to understand how birds are able to adapt and how they are affected by changes in their environment. Many studies have investigated the relationship between morphological traits and certain aspects of the performance and ecological niche of these animals. However, the relationship between morphological traits and the primary lifestyle of birds has not previously been explored. This paper aims to evaluate the predictive potential of morphological data to determine the primary lifestyle of birds through a tree-based machine learning algorithm. By doing this, it is also possible to evaluate these artificial categories that we used to split up birds and know whether they are suitable for dividing them in function of shared morphological characteristics or need a redefinition under more discriminant criteria. Supplementary dataset 1 of the AVONET project was used, which comprises the 11 morphological predictors used in this work and the classification according to the primary lifestyle for more than 95% of the existing bird species. For all morphological traits used, statistically significant univariate differences were found between primary lifestyles. The three fitted machine learning models showed high accuracy, in all cases above 78% and superior to the ones achieved through traditional approaches used as contrasts. The results obtained provide evidence that primary lifestyle can be predicted in birds based on morphological traits, as well as more insights about the relevance of functional traits for ecological modeling. This is another step forward in our mechanistic understanding of bird ecology, while exploring how birds have adapted to their environments and how they interact with their surroundings. [ABSTRACT FROM AUTHOR]