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Your search keyword '"Wang, Ming"' showing total 49 results
49 results on '"Wang, Ming"'

11. Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis

Author

Zhang, Xiao-Bin, primary, Hu, Lan, additional, Ming, Quan, additional, Wei, Xiao-Jie, additional, Zhang, Zhen-Yu, additional, Chen, Li-Da, additional, Wang, Ming-Hui, additional, Yao, Weng-Zhen, additional, Huang, Qiu-Fen, additional, Ye, Zhang-Qiang, additional, Cai, Yu-Qing, additional, and Zeng, Hui-Qing, additional

Published
2021
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33. Live Bird Exposure among the General Public, Guangzhou, China, May 2013

Author

Liao, Qiuyan, primary, Yuan, Jun, additional, Lau, Eric H. Y., additional, Chen, Guang Yan, additional, Yang, Zhi Cong, additional, Ma, Xiao Wei, additional, Chen, Jian Dong, additional, Liu, Yan Hui, additional, Wang, Chang, additional, Tang, Xiao Ping, additional, Liu, Yu Fei, additional, Zhuo, Li, additional, Leung, Gabriel M., additional, Zhang, Wei, additional, Cowling, Benjamin J., additional, Wang, Ming, additional, and Fielding, Richard, additional

Published
2015
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37. Salvianolic Acid B Ameliorates Lipopolysaccharide-Induced Albumin Leakage from Rat Mesenteric Venules through Src-Regulated Transcelluar Pathway and Paracellular Pathway

Author

Pan, Chun-Shui, primary, Liu, Ying-Hua, additional, Liu, Yu-Ying, additional, Zhang, Yu, additional, He, Ke, additional, Yang, Xiao-Yuan, additional, Hu, Bai-He, additional, Chang, Xin, additional, Wang, Ming-Xia, additional, Wei, Xiao-Hong, additional, Fan, Jing-Yu, additional, Wu, Xin-Min, additional, and Han, Jing-Yan, additional

Published
2015
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40. Genetic Mapping of QTLs Controlling Fatty Acids Provided Insights into the Genetic Control of Fatty Acid Synthesis Pathway in Peanut (Arachis hypogaea L.)

Author

Wang, Ming Li, primary, Khera, Pawan, additional, Pandey, Manish K., additional, Wang, Hui, additional, Qiao, Lixian, additional, Feng, Suping, additional, Tonnis, Brandon, additional, Barkley, Noelle A., additional, Pinnow, David, additional, Holbrook, Corley C., additional, Culbreath, Albert K., additional, Varshney, Rajeev K., additional, and Guo, Baozhu, additional

Published
2015
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46. Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk

Author

Su, Hai-Xiang, primary, Zhou, Hai-Hong, additional, Wang, Ming-Yu, additional, Cheng, Jin, additional, Zhang, Shi-Chao, additional, Hui, Feng, additional, Chen, Xue-Zhong, additional, Liu, Shan-Hui, additional, Liu, Qin-Jiang, additional, Zhu, Zi-Jiang, additional, Hu, Qing-Rong, additional, Wu, Yi, additional, and Ji, Shang-Rong, additional

Published
2014
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47. Intermediate CAG Repeat Expansion in the ATXN2 Gene Is a Unique Genetic Risk Factor for ALS−A Systematic Review and Meta-Analysis of Observational Studies.

Author

Wang, Ming-Dong, Gomes, James, Cashman, Neil R., Little, Julian, and Krewski, Daniel

Subjects
*SCIENTIFIC observation, *META-analysis, *GENE expression, *AMYOTROPHIC lateral sclerosis, *GENETIC polymorphisms
Abstract

Amyotrophic lateral sclerosis (ALS) is a rare degenerative condition of the motor neurons. Over 10% of ALS cases are linked to monogenic mutations, with the remainder thought to be due to other risk factors, including environmental factors, genetic polymorphisms, and possibly gene-environmental interactions. We examined the association between ALS and an intermediate CAG repeat expansion in the ATXN2 gene using a meta-analytic approach. Observational studies were searched with relevant disease and gene terms from MEDLINE, EMBASE, and PsycINFO from January 2010 through to January 2014. All identified articles were screened using disease terms, gene terms, population information, and CAG repeat information according to PRISMA guidelines. The final list of 17 articles was further evaluated based on the study location, time period, and authors to exclude multiple usage of the same study populations: 13 relevant articles were retained for this study. The range 30–33 CAG repeats in the ATXN2 gene was most strongly associated with ALS. The meta-analysis revealed that the presence of an intermediate CAG repeat (30-33) in the ATXN2 gene was associated with an increased risk of ALS [odds ratio (OR) = 4.44, 95%CI: 2.91–6.76)] in Caucasian ALS patients. There was no significant difference in the association of this CAG intermediate repeat expansion in the ATXN2 gene between familial ALS cases (OR = 3.59, 1.58–8.17) and sporadic ALS cases (OR = 3.16, 1.88–5.32). These results indicate that the presence of intermediate CAG repeat expansion in the ATXN2 gene is a specific genetic risk factor for ALS, unlike monogenic mutations with an autosomal dominant transmission mode, which cause a more severe phenotype of ALS, with a higher prevalence in familial ALS. [ABSTRACT FROM AUTHOR]

Published
2014
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48. Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk.

Author

Su, Hai-Xiang, Zhou, Hai-Hong, Wang, Ming-Yu, Cheng, Jin, Zhang, Shi-Chao, Hui, Feng, Chen, Xue-Zhong, Liu, Shan-Hui, Liu, Qin-Jiang, Zhu, Zi-Jiang, Hu, Qing-Rong, Wu, Yi, and Ji, Shang-Rong

Subjects
GENETIC mutation, C-reactive protein, P53 protein, SINGLE nucleotide polymorphisms, COLON cancer, WNT proteins
Abstract

C-reactive protein (CRP) is an established marker of inflammation with pattern-recognition receptor-like activities. Despite the close association of the serum level of CRP with the risk and prognosis of several types of cancer, it remains elusive whether CRP contributes directly to tumorigenesis or just represents a bystander marker. We have recently identified recurrent mutations at the SNP position -286 (rs3091244) in the promoter of CRP gene in several tumor types, instead suggesting that locally produced CRP is a potential driver of tumorigenesis. However, it is unknown whether the -286 site is the sole SNP position of CRP gene targeted for mutation and whether there is any association between CRP SNP mutations and other frequently mutated genes in tumors. Herein, we have examined the genotypes of three common CRP non-coding SNPs (rs7553007, rs1205, rs3093077) in tumor/normal sample pairs of 5 cancer types (n = 141). No recurrent somatic mutations are found at these SNP positions, indicating that the -286 SNP mutations are preferentially selected during the development of cancer. Further analysis reveals that the -286 SNP mutations of CRP tend to co-occur with mutated APC particularly in rectal cancer (p = 0.04; n = 67). By contrast, mutations of CRP and p53 or K-ras appear to be unrelated. There results thus underscore the functional importance of the -286 mutation of CRP in tumorigenesis and imply an interaction between CRP and Wnt signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2014
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49. Intermediate CAG repeat expansion in the ATXN2 gene is a unique genetic risk factor for ALS--a systematic review and meta-analysis of observational studies.

Author

Wang MD, Gomes J, Cashman NR, Little J, and Krewski D

Subjects
Age of Onset, Amyotrophic Lateral Sclerosis epidemiology, Ataxins, Humans, Mortality, Odds Ratio, Prevalence, Risk Factors, Amyotrophic Lateral Sclerosis genetics, Genetic Predisposition to Disease, Nerve Tissue Proteins genetics, Trinucleotide Repeat Expansion
Abstract

Amyotrophic lateral sclerosis (ALS) is a rare degenerative condition of the motor neurons. Over 10% of ALS cases are linked to monogenic mutations, with the remainder thought to be due to other risk factors, including environmental factors, genetic polymorphisms, and possibly gene-environmental interactions. We examined the association between ALS and an intermediate CAG repeat expansion in the ATXN2 gene using a meta-analytic approach. Observational studies were searched with relevant disease and gene terms from MEDLINE, EMBASE, and PsycINFO from January 2010 through to January 2014. All identified articles were screened using disease terms, gene terms, population information, and CAG repeat information according to PRISMA guidelines. The final list of 17 articles was further evaluated based on the study location, time period, and authors to exclude multiple usage of the same study populations: 13 relevant articles were retained for this study. The range 30-33 CAG repeats in the ATXN2 gene was most strongly associated with ALS. The meta-analysis revealed that the presence of an intermediate CAG repeat (30-33) in the ATXN2 gene was associated with an increased risk of ALS [odds ratio (OR) = 4.44, 95%CI: 2.91-6.76)] in Caucasian ALS patients. There was no significant difference in the association of this CAG intermediate repeat expansion in the ATXN2 gene between familial ALS cases (OR = 3.59, 1.58-8.17) and sporadic ALS cases (OR = 3.16, 1.88-5.32). These results indicate that the presence of intermediate CAG repeat expansion in the ATXN2 gene is a specific genetic risk factor for ALS, unlike monogenic mutations with an autosomal dominant transmission mode, which cause a more severe phenotype of ALS, with a higher prevalence in familial ALS.

Published
2014
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