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6. Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population

Author

Wang, Jinjin, primary, Li, Linlin, additional, Zhang, Jiatong, additional, Xie, Jing, additional, Luo, Xinping, additional, Yu, Dahai, additional, Zhao, Jingzhi, additional, Feng, Tianping, additional, Pang, Chao, additional, Yin, Lei, additional, Hu, Fulan, additional, Zhang, Jianfeng, additional, Wang, Yan, additional, Wang, Qian, additional, Zhai, Yujia, additional, You, Haifei, additional, Zhu, Tian, additional, and Hu, Dongsheng, additional

Published
2013
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8. Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population.

Author

Wang, Jinjin, Li, Linlin, Zhang, Jiatong, Xie, Jing, Luo, Xinping, Yu, Dahai, Zhao, Jingzhi, Feng, Tianping, Pang, Chao, Yin, Lei, Hu, Fulan, Zhang, Jianfeng, Wang, Yan, Wang, Qian, Zhai, Yujia, You, Haifei, Zhu, Tian, and Hu, Dongsheng

Subjects
TYPE 2 diabetes, GENETIC polymorphisms, TRANSCRIPTION factors, POPULATION biology, GENETIC epidemiology, ENDOCRINOLOGY
Abstract

Aims: We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China. Methods: In all, 1,842 patients with T2DM and 7,777 normal glucose-tolerant controls underwent genotyping for the T2DM-associated variants rs7903146 (IVS3C/T) and rs290487 (IVS3C/T). W performed a meta-analysis of the association of the risk alleles of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 and T2DM in Han Chinese by combining previous studies with the present study. Results: We found that T2DM was associated with the CC genotype (1.364, 1.137–1.636, p  = 0.001), the recessive model (1.457, 1.156–1.838, p  = 0.001) of rs290487 (IVS3C/T) and haplotype CC (1.116, 1.034–1.204, p  = 0.004) in Han Chinese. Moreover, our meta-analyses supported the association of the T allele (IVS3C/T) of rs7903146 (1.36, 1.24–1.48; p  = 6.404×10−12) and T2DM but not the C allele of rs290487 (IVS3C/T) (0.99, 0.85–1.15, p  = 0.890) in Han Chinese. We found no interactions between behavioral risk factors (smoking, alcohol drinking, and physical activity) and rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms. Conclusions: The CC genotype and the recessive model of the variant rs290487 (IVS3C/T) and CC haplotype of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in TCF7L2 may be associated with T2DM in Han Chinese people in Henan province, China. [ABSTRACT FROM AUTHOR]

Published
2013
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