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29 results on '"Zheng, Shusen"'

10. A Meta-Analysis of Randomized Controlled Trials of Low-Volume Polyethylene Glycol plus Ascorbic Acid versus Standard-Volume Polyethylene Glycol Solution as Bowel Preparations for Colonoscopy

Author

Xie, Qingsong, primary, Chen, Linghui, additional, Zhao, Fengqing, additional, Zhou, Xiaohu, additional, Huang, Pengfei, additional, Zhang, Lufei, additional, Zhou, Dongkai, additional, Wei, Jianfeng, additional, Wang, Weilin, additional, and Zheng, Shusen, additional

Published
2014
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15. Comparative Study of Nanosecond Electric Fields In Vitro and In Vivo on Hepatocellular Carcinoma Indicate Macrophage Infiltration Contribute to Tumor Ablation In Vivo

Author

Chen, Xinhua, primary, Yin, Shengyong, additional, Hu, Chen, additional, Chen, Xinmei, additional, Jiang, Kai, additional, Ye, Shuming, additional, Feng, Xiaowen, additional, Fan, Shifeng, additional, Xie, Haiyang, additional, Zhou, Lin, additional, and Zheng, Shusen, additional

Published
2014
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17. Liver Ischemic Preconditioning (IPC) Improves Intestinal Microbiota Following Liver Transplantation in Rats through 16s rDNA-Based Analysis of Microbial Structure Shift

Author

Ren, Zhigang, primary, Cui, Guangying, additional, Lu, Haifeng, additional, Chen, Xinhua, additional, Jiang, Jianwen, additional, Liu, Hui, additional, He, Yong, additional, Ding, Songming, additional, Hu, Zhenhua, additional, Wang, Weilin, additional, and Zheng, Shusen, additional

Published
2013
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21. Artificial Liver Support System Combined with Liver Transplantation in the Treatment of Patients with Acute-on-Chronic Liver Failure

Author

Xu, Xiao, primary, Liu, Xiaoli, additional, Ling, Qi, additional, Wei, Qiang, additional, Liu, Zhikun, additional, Xu, Xiaowei, additional, Zhou, Lin, additional, Zhang, Min, additional, Wu, Jian, additional, Huang, Jianrong, additional, Sheng, Jifang, additional, Zheng, Shusen, additional, and Li, Lanjuan, additional

Published
2013
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27. Comparative Study of Nanosecond Electric Fields In Vitro and In Vivo on Hepatocellular Carcinoma Indicate Macrophage Infiltration Contribute to Tumor Ablation In Vivo.

Author

Chen, Xinhua, Yin, Shengyong, Hu, Chen, Chen, Xinmei, Jiang, Kai, Ye, Shuming, Feng, Xiaowen, Fan, Shifeng, Xie, Haiyang, Zhou, Lin, and Zheng, Shusen

Subjects
ELECTRIC field therapy, LIVER cancer, MACROPHAGES, CATHETER ablation, CANCER relapse, IN vitro studies, COMPARATIVE studies, PROGNOSIS
Abstract

Background and Aim: Recurrence and metastasis are associated with poor prognosis in hepatocellular carcinoma even in the patients who have undergone radical resection. Therefore, effective treatment is urgently needed for improvement of patients' survival. Previously, we reported that nanosecond pulse electric fields (nsPEFs) can ablate melanoma by induction of apoptosis and inhibition of angiogenesis. This study aims to investigate the in vivo ablation strategy by comparing the dose effect of nanosecond electric fields in vitro and in vivo on hepatocellular carcinoma. Materials and Methods: Four hepatocellular carcinoma cell lines HepG2, SMMC7721, Hep1-6, and HCCLM3 were pulsed to test the anti-proliferation and anti-migration ability of 100 ns nsPEFs in vitro. The animal model of human subdermal xenograft HCCLM3 cells into BALB/c nude mouse was used to test the anti-tumor growth and macrophage infiltration in vivo. Results: In vitro assays showed anti-tumor effect of nsPEFs is dose-dependant. But the in vivo study showed the strategy of low dose and multiple treatments is superior to high dose single treatment. The macrophages infiltration significantly increased in the tumors which were treated by multiple low dose nsPEFs. Conclusion: The low dose multiple nsPEFs application is more efficient than high dose single treatment in inhibiting the tumor volume in vivo, which is quite different from the dose-effect relationship in vitro. Beside the electric field strength, the macrophage involvement must be considered to account for effect variability and toxicology in vivo. [ABSTRACT FROM AUTHOR]

Published
2014
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28. De novo Cancers Following Liver Transplantation: A Single Center Experience in China.

Author

Yu, Songfeng, Gao, Feng, Yu, Jun, Yan, Sheng, Wu, Jian, Zhang, Min, Wang, Weilin, and Zheng, Shusen

Subjects
LIVER transplantation, CANCER risk factors, LIVER cancer, CANCER-related mortality, MEDICAL literature, RETROSPECTIVE studies
Abstract

Background: De novo cancers are a growing problem that has become one of the leading causes of late mortality after liver transplantation. The incidences and risk factors varied among literatures and fewer concerned the Eastern population. Aims: The aim of this study was to examine the incidence and clinical features of de novo cancers after liver transplantation in a single Chinese center. Methods: 569 patients who received liver transplantation and survived for more than 3 months in a single Chinese center were retrospectively reviewed. Results: A total of 18 de novo cancers were diagnosed in 17 recipients (13 male and 4 female) after a mean of 41±26 months, with an overall incidence of 3.2%, which was lower than that in Western people. Of these, 8 (3.32%) cases were from 241 recipients with malignant liver diseases before transplant, while 10 (3.05%) cases were from 328 recipients with benign diseases. The incidence rates were comparable, p = 0.86. Furthermore, 2 cases developed in 1 year, 5 cases in 3 years and 11 cases over 3 years. The most frequent cancers developed after liver transplantation were similar to those in the general Chinese population but had much higher incidence rates. Conclusions: Liver transplant recipients were at increased risk for developing de novo cancers. The incidence rates and pattern of de novo cancers in Chinese population are different from Western people due to racial and social factors. Pre-transplant malignant condition had no relationship to de novo cancer. Exact risk factors need further studies. [ABSTRACT FROM AUTHOR]

Published
2014
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29. Comparative Study of Nanosecond Electric Fields In Vitro and In Vivo on Hepatocellular Carcinoma Indicate Macrophage Infiltration Contribute to Tumor Ablation In Vivo.

Author

Chen, Xinhua, Yin, Shengyong, Hu, Chen, Chen, Xinmei, Jiang, Kai, Ye, Shuming, Feng, Xiaowen, Fan, Shifeng, Xie, Haiyang, Zhou, Lin, and Zheng, Shusen

Subjects
*ELECTRIC field therapy, *LIVER cancer, *MACROPHAGES, *CATHETER ablation, *CANCER relapse, *IN vitro studies, *COMPARATIVE studies, *PROGNOSIS
Abstract

Background and Aim: Recurrence and metastasis are associated with poor prognosis in hepatocellular carcinoma even in the patients who have undergone radical resection. Therefore, effective treatment is urgently needed for improvement of patients' survival. Previously, we reported that nanosecond pulse electric fields (nsPEFs) can ablate melanoma by induction of apoptosis and inhibition of angiogenesis. This study aims to investigate the in vivo ablation strategy by comparing the dose effect of nanosecond electric fields in vitro and in vivo on hepatocellular carcinoma. Materials and Methods: Four hepatocellular carcinoma cell lines HepG2, SMMC7721, Hep1-6, and HCCLM3 were pulsed to test the anti-proliferation and anti-migration ability of 100 ns nsPEFs in vitro. The animal model of human subdermal xenograft HCCLM3 cells into BALB/c nude mouse was used to test the anti-tumor growth and macrophage infiltration in vivo. Results: In vitro assays showed anti-tumor effect of nsPEFs is dose-dependant. But the in vivo study showed the strategy of low dose and multiple treatments is superior to high dose single treatment. The macrophages infiltration significantly increased in the tumors which were treated by multiple low dose nsPEFs. Conclusion: The low dose multiple nsPEFs application is more efficient than high dose single treatment in inhibiting the tumor volume in vivo, which is quite different from the dose-effect relationship in vitro. Beside the electric field strength, the macrophage involvement must be considered to account for effect variability and toxicology in vivo. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

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