Search

Your search keyword '"de Gruijl, Tanja D."' showing total 7 results
Start Over Author "de Gruijl, Tanja D." Search Limiters Peer Reviewed Journal plos one
7 results on '"de Gruijl, Tanja D."'

5. IL-10 Conditioning of Human Skin Affects the Distribution of Migratory Dendritic Cell Subsets and Functional T Cell Differentiation

Author

Lindenberg, Jelle J., primary, Oosterhoff, Dinja, additional, Sombroek, Claudia C., additional, Lougheed, Sinéad M., additional, Hooijberg, Erik, additional, Stam, Anita G. M., additional, Santegoets, Saskia J. A. M., additional, Tijssen, Henk J., additional, Buter, Jan, additional, Pinedo, Herbert M., additional, van den Eertwegh, Alfons J. M., additional, Scheper, Rik J., additional, Koenen, Hans J. P. M., additional, van de Ven, Rieneke, additional, and de Gruijl, Tanja D., additional

Published
2013
Full Text
View/download PDF

7. Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells.

Author

Fehres, Cynthia. M., Bruijns, Sven C. M., Sotthewes, Brigit N., Kalay, Hakan, Schaffer, Lana, Head, Steven R., de Gruijl, Tanja D., Garcia-Vallejo, Juan J., and van Kooyk, Yvette

Subjects
PHENOTYPES, CD14 antigen, ANTIGEN presenting cells, LANGERHANS cells, DENDRITIC cells
Abstract

Cutaneous antigen presenting cells (APCs) are critical for the induction and regulation of skin immune responses. The human skin contains phenotypically and functionally distinct APCs subsets that are present at two separated locations. While CD1ahigh LCs form a dense network in the epidermis, the CD14+ and CD1a+ APCs reside in the dermal compartment. A better understanding of the biology of human skin APC subsets is necessary for the improvement of vaccine strategies that use the skin as administration route. In particular, progress in the characterization of uptake and activatory receptors will certainly improve APC-targeting strategies in vaccination. Here we performed a detailed analysis of the expression and function of glycan-binding and pattern-recognition receptors in skin APC subsets. The results demonstrate that under steady state conditions human CD1a+ dermal dendritic cells (DCs) were phenotypically most mature as measured by the expression of CD83 and CD86, whereas the CD14+ cells showed a higher expression of the CLRs DC-SIGN, mannose receptor and DCIR and had potent antigen uptake capacity. Furthermore, steady state LCs showed superior antigen cross-presentation as compared to the dermal APC subsets. Our results also demonstrate that the TLR3 ligand polyribosinic-polyribocytidylic acid (pI:C) was the most potent stimulator of cytokine production by both LCs and dDCs. These studies warrant further exploration of human CD1a+ dDCs and LCs as target cells for cancer vaccination to induce anti-tumor immune responses. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results