1. Early transcriptional responses of bovine chorioallantoic membrane explants to wild type, ΔvirB2 or ΔbtpB Brucella abortus infection
- Author
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Juliana Pinto da Silva Mol, Alex F. Carvalho, Renée M. Tsolis, Yao Hui Sun, Renato L. Santos, Tatiane A. Paixão, Érica Azevedo Costa, and Dellagostin, Odir A
- Subjects
Bacterial Diseases ,Transcription, Genetic ,Operon ,Mutant ,Brucella abortus ,Chorioallantoic Membrane ,Pathogenesis ,Brucellosis, Bovine ,Pregnancy ,Zoonoses ,Medicine and Health Sciences ,2.1 Biological and endogenous factors ,Aetiology ,Multidisciplinary ,Bovine ,Up-Regulation ,Chorioallantoic membrane ,Infectious Diseases ,Veterinary Diseases ,Medicine ,Female ,Transcription ,Research Article ,General Science & Technology ,Science ,Biology ,Brucellosis ,Proinflammatory cytokine ,Microbiology ,Vaccine Related ,Immune system ,Genetic ,Biodefense ,MD Multidisciplinary ,Genetics ,Animals ,Inflammatory and Immune System ,Secretion ,Inflammation ,Prevention ,Wild type ,Biology and Life Sciences ,Emerging Infectious Diseases ,Tissue Array Analysis ,Immunology ,Veterinary Science ,Cattle - Abstract
The pathogenesis of the Brucella-induced inflammatory response in the bovine placenta is not completely understood. In this study we evaluated the role of the B. abortus Type IV secretion system and the anti-inflammatory factor BtpB in early interactions with bovine placental tissues. Transcription profiles of chorioallantoic membrane (CAM) explants inoculated with wild type (strain 2308), ΔvirB2 or ΔbtpB Brucella abortus were compared by microarray analysis at 4 hours post infection. Transcripts with significant variation (>2 fold change; P
- Published
- 2014